KEGG   Desmodus rotundus (common vampire bat): 112296365
Entry
112296365         CDS       T05907                                 
Symbol
INSR
Name
(RefSeq) insulin receptor isoform X1
  KO
K04527  insulin receptor [EC:2.7.10.1]
Organism
dro  Desmodus rotundus (common vampire bat)
Pathway
dro04010  MAPK signaling pathway
dro04014  Ras signaling pathway
dro04015  Rap1 signaling pathway
dro04022  cGMP-PKG signaling pathway
dro04066  HIF-1 signaling pathway
dro04068  FoxO signaling pathway
dro04072  Phospholipase D signaling pathway
dro04150  mTOR signaling pathway
dro04151  PI3K-Akt signaling pathway
dro04152  AMPK signaling pathway
dro04211  Longevity regulating pathway
dro04213  Longevity regulating pathway - multiple species
dro04520  Adherens junction
dro04910  Insulin signaling pathway
dro04913  Ovarian steroidogenesis
dro04923  Regulation of lipolysis in adipocytes
dro04930  Type II diabetes mellitus
dro04931  Insulin resistance
dro04932  Non-alcoholic fatty liver disease
dro04960  Aldosterone-regulated sodium reabsorption
dro05010  Alzheimer disease
dro05415  Diabetic cardiomyopathy
Brite
KEGG Orthology (KO) [BR:dro00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    112296365 (INSR)
   04014 Ras signaling pathway
    112296365 (INSR)
   04015 Rap1 signaling pathway
    112296365 (INSR)
   04066 HIF-1 signaling pathway
    112296365 (INSR)
   04068 FoxO signaling pathway
    112296365 (INSR)
   04072 Phospholipase D signaling pathway
    112296365 (INSR)
   04022 cGMP-PKG signaling pathway
    112296365 (INSR)
   04151 PI3K-Akt signaling pathway
    112296365 (INSR)
   04152 AMPK signaling pathway
    112296365 (INSR)
   04150 mTOR signaling pathway
    112296365 (INSR)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04520 Adherens junction
    112296365 (INSR)
 09150 Organismal Systems
  09152 Endocrine system
   04910 Insulin signaling pathway
    112296365 (INSR)
   04923 Regulation of lipolysis in adipocytes
    112296365 (INSR)
   04913 Ovarian steroidogenesis
    112296365 (INSR)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    112296365 (INSR)
  09149 Aging
   04211 Longevity regulating pathway
    112296365 (INSR)
   04213 Longevity regulating pathway - multiple species
    112296365 (INSR)
 09160 Human Diseases
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    112296365 (INSR)
  09166 Cardiovascular disease
   05415 Diabetic cardiomyopathy
    112296365 (INSR)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    112296365 (INSR)
   04932 Non-alcoholic fatty liver disease
    112296365 (INSR)
   04931 Insulin resistance
    112296365 (INSR)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:dro01001]
    112296365 (INSR)
  09183 Protein families: signaling and cellular processes
   04090 CD molecules [BR:dro04090]
    112296365 (INSR)
Enzymes [BR:dro01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     112296365 (INSR)
Protein kinases [BR:dro01001]
 Receptor tyrosine kinases (RTK)
  INSR family [OT]
   112296365 (INSR)
CD molecules [BR:dro04090]
 Proteins
  112296365 (INSR)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Recep_L_domain Pkinase Furin-like fn3 Insulin_TMD Kinase-like DUF4476 B2
Other DBs
NCBI-GeneID: 112296365
NCBI-ProteinID: XP_024406974
Position
Unknown
AA seq 1339 aa
MFSLIVCPGMDIRNNLTRLHELANCSVIEGHLQILLMFKTRPEDFRDLSFPKLIMVTDYL
LLFRVYGLESLKDLFPNLTVIRGSRLFFNYALVIFEMVHLKELGLYSLMNITRGAVRIEK
NNELCYLATIDWSRILDSVEDNYIVLNKDDNEECGDICPGTAKGKTSCPATVINGQFVER
CWTHSHCQKVCPTVCKSHGCTAEGLCCHSECLGNCSEPDDPTKCVACRNFYLDGRCVETC
PPPYYHFQDWRCVNFSFCQDLHNTCKNSRRPGCHQYVIHNNKCIPECPSGYTMNSSNLMC
TPCLGPCPKVCHLLEGEKTIDSVTSAQELRGCTVVNGSLIINIRGGNNLAAELESNLGLI
EEISGYLKIRRSYALVSLSFFRKLRLIRGDTLEIGNYSFYALDNQNLRQLWDWSKHNLTI
TQGKLFFHYNPKLCLSEIHKMEEVSGTKGRQERNDIALKTNGDQASCENELLKFSYIRTT
FDKILLRWEPYWPPDFRDLLGFMLFYKEAPYQNVTEFDGQDACGSNSWTVVDIDPPVRSN
DPKSQSHPGWLMRGLKPWTQYAIFVKTLVTFSDERRTYGAKSDIIYVQTDATNPSVPLDP
ISVSNSSSQIILKWKPPSDPNGNITHYLVFWERQAEDSELYELDYCLKGLKLPSRTWSPP
LESEGSQKHNRSEDEESAGECCSCPKTDAQILKELEESSFRKTFEDYLHNVVFVPRPSSR
KRRALGDEGNVTTAVPTAPSFPNTSSTSMPTNSEEHRPFEKVVNKESLVISGLRHFTGYR
IELQACNQDAPEERCSVAAYVSARTMPEAKADDIVGPVAHEFDNNGVHLMWQEPKEPNGL
IVLYEVSYRRHGDEELHLCISRRNFAQEQGCRLRGLLPGNYSVRVRATSLAGNGSWTETT
YFYVTDYLDIGDTNIAKIIIGPLIFVFLFSVVIGSIYLFLRKRQPDGPLGPLYASSNPEY
LSASDVFPCSVYVPDEWEVPREKITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTV
NESASLRERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLR
PEAENNPGRPPPTLHEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFG
MTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQG
LSNEQVLKFVMDGGHLDQPDNCPERLTELMRSCWQFNPKMRPTFLEIVDLLKDDLHPSFP
EVSFFHSEENKAPESEELEMECEDMESVPLDRPSHSPREEGVGSPLGLKRSYEEHTPYTH
MNGAKRNGRALTLPRSSPS
NT seq 4020 nt   +upstreamnt  +downstreamnt
atgttttcactcatagtgtgtcccggcatggacatccggaacaacctcacgcggctgcac
gagctggccaactgctcggtcattgaaggacatttgcagattctgttgatgttcaagacg
aggcctgaggatttccgagacctcagtttccccaaactcatcatggtcactgactacttg
ctgctgttccgggtctacgggctggagagcctgaaggacctgttccccaacctcacggtc
atccggggctcccgtctcttcttcaactacgcgctggtcatctttgagatggttcacctg
aaggagctgggcctctacagcctgatgaacatcacccggggggctgtccgcatcgagaag
aacaatgagctctgctacctggccaccatcgactggtcgcgcatcctggactccgtggag
gataattacattgtgctgaacaaagacgacaacgaggaatgtggggacatctgtccaggc
actgcgaagggcaagaccagctgccctgccacggtcattaacgggcagtttgtcgagcgg
tgttggactcacagccactgccagaaagtctgcccgaccgtctgtaagtcgcatggctgc
actgccgagggcctctgctgccacagcgagtgcctgggcaactgctccgagcccgacgac
cccaccaagtgcgtggcctgccgcaacttctacctggatggccggtgcgtggagacctgc
ccgcccccgtactaccacttccaagactggcgctgcgtgaacttcagcttctgccaggac
ctgcacaacacgtgcaagaactcgcggaggccgggctgccaccagtatgtcattcacaat
aacaagtgcatccctgaatgtccctctggctacacgatgaattccagcaacttgatgtgc
acgccatgtctgggcccctgtcccaaggtctgtcacctcctggaaggcgagaagaccatc
gactcggtgacgtctgcccaggagctgcgaggctgcactgttgtcaatgggagcctcatc
atcaacattcgagggggcaacaacctggcagctgagctagagtccaacctcggcctcatt
gaagaaatctcagggtatctgaaaatccgccgctcctatgctctcgtgtcactgtccttc
ttccggaagttacgtctgattcggggggacaccttggaaatcgggaactactctttctat
gccttagacaaccagaacctgaggcagctgtgggactggagcaagcacaaccttaccatc
actcaggggaaactcttcttccactacaatcccaaactctgcttgtcggaaattcataaa
atggaggaagtttcgggaaccaaggggcgccaggagaggaacgacatcgccttgaagacc
aatggggaccaggcgtcctgtgaaaatgaattacttaaattttcttacattcggacaact
tttgacaagatcttgctgaggtgggagccgtactggccccctgacttccgagacctcctg
ggattcatgctgttctacaaagaggccccttaccagaatgtgacggagttcgatgggcag
gatgcgtgtggatccaacagctggacagtggtggacattgacccgcctgtgcggtccaac
gaccctaagtcccagagccaccccgggtggctcatgcggggtctcaagccctggacacag
tatgccatcttcgtgaagaccttggtcaccttttccgacgagcgtcgcacgtatggggcc
aagagtgacatcatctatgtccagacggacgccaccaacccttccgtgcccctggacccc
atctcggtttctaactcctcatcccagatcatcctgaagtggaagcctccctctgacccc
aacggcaacatcacacactacctggttttctgggagaggcaggcagaggacagtgagctg
tacgagctggattattgcctcaaagggctgaagctgccctcccggacctggtccccgcca
cttgagtctgagggctcccagaagcacaaccggagcgaggacgaggagtctgccggggag
tgctgctcctgcccaaagaccgacgctcagatcctgaaggagctggaggagtcctcgttc
cggaagacatttgaggattacctgcacaatgtggtttttgtccccaggccgtcgtcgagg
aagcgcagggcccttggggacgaggggaatgtgacgacggctgtgcccacagctcccagt
ttccccaatacctcctctaccagcatgcccacgaactcggaggagcaccggccctttgag
aaggtggtgaacaaagagtcgctggtcatctctggcctgcgccacttcaccggctaccgc
atcgagctgcaggcttgcaaccaagacgcccccgaggaaagatgcagcgtggcagcctac
gtcagcgccaggaccatgccggaagccaaggcggatgacatcgtcggccccgtggcccat
gaattcgacaacaacggcgtgcatttgatgtggcaggagcccaaggagcccaacggcctg
atcgtgctgtacgaagtgagctaccggcgacacggcgatgaggagctgcacctgtgcatc
tcccgcaggaattttgctcaggagcagggctgcaggctgcgtgggctgctgccagggaat
tacagcgtgcgagtacgggccacctccctggcgggcaacggctcctggacggaaaccacc
tatttttacgtgacagactatctagacattggagatacaaacattgcaaaaattatcatc
ggccccctcatctttgtcttcctcttcagtgttgtgattggaagtatttatctgttcctg
agaaagaggcagccagatgggccgctgggaccactgtatgcttcttcaaaccccgagtac
ctcagtgccagtgatgtgttcccgtgttctgtgtatgtgccggacgagtgggaggtgcct
cgcgagaagatcaccctcctgcgggagctggggcagggctccttcggcatggtgtacgag
ggcaacgccagggacatcatcaagggtgaggcggagacccgagtggcggtgaagacagtg
aacgagtcagccagcctgcgggagcggatcgagtttctcaacgaggcctccgtcatgaaa
ggcttcacctgccatcacgtggtccgtctcctgggggtggtatccaagggccagcccacg
ctggtggtgatggagttgatggcccacggggacctgaagagctacctgcgttccctgcgg
cctgaggcggagaataaccccggccgccctccccccaccctgcacgagatgatccagatg
gcggccgagattgcggacgggatggcctacctgaacgcgaagaagtttgtgcaccgggac
ctcgcagctcgcaactgcatggtcgcccacgacttcactgtcaaaattggagactttggg
atgaccagagacatctacgaaacggactattaccggaaaggtggcaaaggtctgctgccc
gtgcggtggatgtcgcccgaatccctgaaggatggggtcttcaccacctcctctgacatg
tggtccttcggcgtggtcctctgggaaatcaccagcctggcggaacagccgtaccaaggc
ctctccaatgagcaggtgctgaaattcgtcatggatggagggcatctggatcagcctgac
aactgtccagagagactcaccgagttgatgcgctcgtgctggcagttcaaccccaagatg
aggccgaccttcctagagatcgttgacttgcttaaggacgacctgcaccccagctttcca
gaagtttccttcttccacagcgaggagaacaaggcacccgagagcgaggaactggagatg
gagtgcgaggacatggagagcgtgcccctggaccggccctcacactccccgagggaggaa
ggggtggggtccccactgggtctcaagcggagttatgaggagcacaccccctacacccac
atgaacggggccaagaggaacgggcgggccctgactctgccccggtccagcccttcctaa

  All links  
Ontology (4)   
   KEGG BRITE (4)   
Pathway (22)   
   KEGG PATHWAY (22)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (3)   
   KEGG ORTHOLOGY (1)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
Protein sequence (3)   
   RefSeq(pep) (3)   
DNA sequence (5)   
   RefSeq(nuc) (3)   
   GenBank (1)   
   EMBL (1)   
Protein domain (9)   
   Pfam (9)   
All databases (48)   

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