KEGG   Desmodus rotundus (common vampire bat): 112300474
Entry
112300474         CDS       T05907                                 

Gene name
CHUK
Definition
(RefSeq) LOW QUALITY PROTEIN: inhibitor of nuclear factor kappa-B kinase subunit alpha
  KO
K04467  inhibitor of nuclear factor kappa-B kinase subunit alpha [EC:2.7.11.10]
Organism
dro  Desmodus rotundus (common vampire bat)
Pathway
dro01523  Antifolate resistance
dro04010  MAPK signaling pathway
dro04014  Ras signaling pathway
dro04062  Chemokine signaling pathway
dro04064  NF-kappa B signaling pathway
dro04068  FoxO signaling pathway
dro04150  mTOR signaling pathway
dro04151  PI3K-Akt signaling pathway
dro04210  Apoptosis
dro04380  Osteoclast differentiation
dro04620  Toll-like receptor signaling pathway
dro04621  NOD-like receptor signaling pathway
dro04622  RIG-I-like receptor signaling pathway
dro04623  Cytosolic DNA-sensing pathway
dro04625  C-type lectin receptor signaling pathway
dro04657  IL-17 signaling pathway
dro04658  Th1 and Th2 cell differentiation
dro04659  Th17 cell differentiation
dro04660  T cell receptor signaling pathway
dro04662  B cell receptor signaling pathway
dro04668  TNF signaling pathway
dro04920  Adipocytokine signaling pathway
dro05010  Alzheimer disease
dro05132  Salmonella infection
dro05135  Yersinia infection
dro05142  Chagas disease
dro05145  Toxoplasmosis
dro05160  Hepatitis C
dro05161  Hepatitis B
dro05162  Measles
dro05163  Human cytomegalovirus infection
dro05164  Influenza A
dro05165  Human papillomavirus infection
dro05166  Human T-cell leukemia virus 1 infection
dro05167  Kaposi sarcoma-associated herpesvirus infection
dro05168  Herpes simplex virus 1 infection
dro05169  Epstein-Barr virus infection
dro05170  Human immunodeficiency virus 1 infection
dro05200  Pathways in cancer
dro05212  Pancreatic cancer
dro05215  Prostate cancer
dro05220  Chronic myeloid leukemia
dro05221  Acute myeloid leukemia
dro05222  Small cell lung cancer
dro05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
dro05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:dro00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    112300474 (CHUK)
   04014 Ras signaling pathway
    112300474 (CHUK)
   04064 NF-kappa B signaling pathway
    112300474 (CHUK)
   04668 TNF signaling pathway
    112300474 (CHUK)
   04068 FoxO signaling pathway
    112300474 (CHUK)
   04151 PI3K-Akt signaling pathway
    112300474 (CHUK)
   04150 mTOR signaling pathway
    112300474 (CHUK)
 09140 Cellular Processes
  09143 Cell growth and death
   04210 Apoptosis
    112300474 (CHUK)
 09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    112300474 (CHUK)
   04621 NOD-like receptor signaling pathway
    112300474 (CHUK)
   04622 RIG-I-like receptor signaling pathway
    112300474 (CHUK)
   04623 Cytosolic DNA-sensing pathway
    112300474 (CHUK)
   04625 C-type lectin receptor signaling pathway
    112300474 (CHUK)
   04660 T cell receptor signaling pathway
    112300474 (CHUK)
   04658 Th1 and Th2 cell differentiation
    112300474 (CHUK)
   04659 Th17 cell differentiation
    112300474 (CHUK)
   04657 IL-17 signaling pathway
    112300474 (CHUK)
   04662 B cell receptor signaling pathway
    112300474 (CHUK)
   04062 Chemokine signaling pathway
    112300474 (CHUK)
  09152 Endocrine system
   04920 Adipocytokine signaling pathway
    112300474 (CHUK)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    112300474 (CHUK)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    112300474 (CHUK)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    112300474 (CHUK)
  09162 Cancer: specific types
   05212 Pancreatic cancer
    112300474 (CHUK)
   05221 Acute myeloid leukemia
    112300474 (CHUK)
   05220 Chronic myeloid leukemia
    112300474 (CHUK)
   05215 Prostate cancer
    112300474 (CHUK)
   05222 Small cell lung cancer
    112300474 (CHUK)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    112300474 (CHUK)
  09166 Cardiovascular disease
   05418 Fluid shear stress and atherosclerosis
    112300474 (CHUK)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    112300474 (CHUK)
   05135 Yersinia infection
    112300474 (CHUK)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    112300474 (CHUK)
   05170 Human immunodeficiency virus 1 infection
    112300474 (CHUK)
   05162 Measles
    112300474 (CHUK)
   05164 Influenza A
    112300474 (CHUK)
   05161 Hepatitis B
    112300474 (CHUK)
   05160 Hepatitis C
    112300474 (CHUK)
   05168 Herpes simplex virus 1 infection
    112300474 (CHUK)
   05163 Human cytomegalovirus infection
    112300474 (CHUK)
   05167 Kaposi sarcoma-associated herpesvirus infection
    112300474 (CHUK)
   05169 Epstein-Barr virus infection
    112300474 (CHUK)
   05165 Human papillomavirus infection
    112300474 (CHUK)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    112300474 (CHUK)
   05142 Chagas disease
    112300474 (CHUK)
  09176 Drug resistance: antineoplastic
   01523 Antifolate resistance
    112300474 (CHUK)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:dro01001]
    112300474 (CHUK)
Enzymes [BR:dro01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.10  IkappaB kinase
     112300474 (CHUK)
Protein kinases [BR:dro01001]
 Serine/threonine kinases: Other
  IKK family [OT]
   112300474 (CHUK)
SSDB
Motif
Pfam: IKBKB_SDD Pkinase PK_Tyr_Ser-Thr Ribosomal_L23eN IKKbetaNEMObind Ribosomal_L23 Pkinase_fungal Kdo TBK1_ULD
Other DBs
NCBI-GeneID: 112300474
NCBI-ProteinID: XP_024411582
Position
Unknown
AA seq 874 aa
MAPKAKKEAPAFPKAEAKAKALKAKKTVLKGFHRHRKKKIHMSPTLRRPKTXGLQRQPKY
PRKSASRRNKLDHYANIKFPLTPESAMKKIEDNNTLVFIVDVKANKHQIKQAVKKLYDFD
VAKVSTLISLPERRRHVXLAPEYDALDVANKIGIIETESSWLIELDLKIAIKSCRLELST
KNRERWCHEIQIMKKLNHSNVVKACDVPEELNCLINDVPLLAMEYCSGGDLRKLLNKPEN
CCGLKESQILSLLSDIGSGIRYLHENKIIHRDLKPENIVLQDVGGKIIHKIIDLGYAKDV
DQGSLCTSFVGTLQYLAPELFENKPYTATVDYWSFGTMVFECIAGYRPFLHHLQPFTWHE
KIKKKDPKCIFACEEMTGEVRFSSHLPQPNNLCSLIVDPMENWLQLMLNWDPQQRGGPVD
LTLKQPRCFVLMDHILNLKIVHILNMTSAKIISFLLPPDESLHSLQSRIERETGINTASQ
ELLSETGISLDPRKPASQCVLDGVRGCDSYMVYLFDKSKTVYEGPFASRSLSDCVNYIVR
DSKIQLPIIQLRKVWAEAVHYVSGLKEDYSRLFQGQRAAMLSLLRYNTNLTKMKNALISA
SQQLKAKLEFFHKSIQLDLERYSEQMTYGISSEKMLKAWKEMEEKAIHYAEVGVIGYLED
QIMCLHTEIMELQKSPYGRRQGDLMESLEQRAIDLYKQLKHRPSDHSYSDSTEMVKTIVH
TVQSQDRVLKELFGHLSKLLGCKQKIIDLLPKVEMVLSDIKEADSTVMFMQGKRQKEIWH
LLKIACTQSSARSPVGSSLEGAVTTPQASAWLPPASVEREHPLSCVVTPQDGETLAQMIE
ENLNCLGHLSTIIHEVNEEQSGRMMNLDWSWLTE
NT seq 2625 nt   +upstreamnt  +downstreamnt
atggctcccaaagcaaagaaggaagcccctgcttttcctaaagccgaggccaaggcaaag
gctttgaaggcaaagaaaacagtactaaaaggtttccacaggcacagaaaaaagaagatc
cacatgtcacccaccttgcggaggcctaagacanncgggctccaaaggcagcctaaatat
cctcggaagagcgcctccaggagaaacaagcttgaccactatgctaacattaagttcccc
ctgactcccgagtcagccatgaagaagatagaagacaacaatacacttgtgttcattgtg
gatgtcaaggccaacaagcaccagatcaaacaggctgtgaagaagctctatgactttgac
gtggccaaggtcagcaccctgatcagcctgccggagagaagaaggcatgtgnnactggct
ccagagtatgatgctttggatgttgcgaacaaaattgggatcattgaaactgagtccagc
tggctaattgaacttgatctcaaaatagcaattaagtcttgtcgcctagagctgagtacc
aaaaacagagaacggtggtgccatgaaatccagatcatgaaaaagttgaaccactccaat
gttgtaaaggcctgtgatgttcctgaggaactgaattgtttgattaatgatgtgcctctt
ctagcaatggaatactgttcgggaggagatctccggaagctactgaacaaaccagaaaac
tgctgtggacttaaagaaagccagatactttctttactgagtgatataggatctgggatc
cgatatttgcatgaaaacaaaattatacatcgtgacctaaaaccagaaaacatagttctt
caggatgttggtggaaagatcatacataaaataattgatctgggatatgccaaagatgtt
gatcaaggaagtctgtgtacatcttttgtgggaacattgcagtatctggccccagagctc
tttgagaataagccttacacagccactgttgattattggagctttgggaccatggtgttt
gaatgtattgctggatataggccttttttacatcatctccagccatttacctggcatgag
aagattaagaagaaggatcccaagtgtatatttgcctgtgaagagatgacaggagaagtt
cggtttagtagtcatttacctcaaccaaataacctttgtagtttaatagtagatcccatg
gaaaactggctacaattgatgctgaattgggatcctcagcagagaggaggacctgttgat
cttactttgaagcagccaaggtgttttgtattaatggatcacattctgaatttgaagata
gtacacatcctaaatatgacttctgcaaagataatttcttttctcttaccacctgatgaa
agtcttcattcgctgcagtctcgtattgagcgtgaaactggaataaatactgcttctcaa
gagcttctttcagagacgggaatttctcttgatcctcggaaaccagcctctcaatgtgta
ctagatggagtaagaggctgtgatagctatatggtttatttgtttgataaaagtaagact
gtgtatgaaggaccatttgcttccagaagtttatctgactgtgtaaattatattgtacgg
gacagcaaaatacagcttccaattatacagctgcgtaaagtatgggctgaagcagtgcac
tatgtgtctgggctgaaagaagactacagcagactctttcaagggcaaagagcagcaatg
ttaagtcttcttagatataatactaacttgacaaaaatgaagaatgctttgatctcagca
tcccagcagctgaaggctaaactggagttttttcacaaaagcattcagcttgacttggaa
agatatagtgagcagatgacttatgggatatcctcagaaaaaatgttaaaagcatggaag
gaaatggaagaaaaggccatccactatgctgaggtaggtgtcattggatacctggaggat
cagatcatgtgcctgcacactgaaatcatggagctacagaaaagcccttatggaagacgt
cagggagacttgatggaatctctggaacagcgtgccattgatctgtacaagcagttaaag
cacagaccttcagatcactcctacagtgacagcacggagatggtgaagaccatcgtgcac
accgtgcagagtcaggaccgggttctgaaggagctttttggtcatctgagcaagctgttg
ggctgtaagcagaagattattgacctactgcccaaggtggaaatggtcctcagtgacatc
aaagaagctgacagtactgtcatgtttatgcagggaaagaggcagaaagaaatatggcat
ctccttaaaattgcttgtacacagagttcggctcgatcccccgtaggatccagtctagaa
ggtgcagtaactacccctcaggcatcagcatggctgcccccagcttcagtagaacgtgaa
catcctctgtcatgcgtggtaactcctcaagatggggagactttggcacaaatgatagaa
gaaaatttgaactgtcttggccatttaagcactattattcatgaagtaaatgaggaacag
agcggtaggatgatgaatcttgattggagttggttaacggaatga

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