KEGG   DRUG: AzathioprineHelp
Entry
D00238                      Drug                                   

Name
Azathioprine (JP17/USP/INN);
Azasan (TN);
Imuran (TN)
Product
  Generic
Formula
C9H7N7O2S
Exact mass
277.0382
Mol weight
277.2626
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Anti-inflammatory
 DG01985  Disease modifying anti-rheumatic drugs (DMARDs)
Remark
Same as: C06837
Therapeutic category: 3999
ATC code: L04AX01
Chemical structure group: DG00743
Product (DG00743): D00238<JP/US> D03033<US>
Efficacy
Immunosuppressant, Nucleic acid biosynthesis inhibitor
  Disease
Prevention of rejection in renal homotransplantation [DS:H00083]
Rheumatoid arthritis [DS:H00630]
Comment
Azathioprine is metabolized to 6-mercaptopurine (6-MP) [DR:D04931]
Interaction
Drug interaction
Structure map
map07046  Immunosuppressive agents
map07050  Antirheumatics - DMARDs and biological agents
Other map
map00983  Drug metabolism - other enzymes
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L04 IMMUNOSUPPRESSANTS
   L04A IMMUNOSUPPRESSANTS
    L04AX Other immunosuppressants
     L04AX01 Azathioprine
      D00238  Azathioprine (JP17/USP/INN) <JP/US>
USP drug classification [BR:br08302]
 Immunological Agents
  Immune Suppressants
   Azathioprine
    D00238  Azathioprine (JP17/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 3  Agents affecting metabolism
  39  Other agents affecting metabolism
   399  Miscellaneous
    3999  Others
     D00238  Azathioprine (JP17/USP/INN)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00238  Azathioprine
  D00238  Azathioprine tablets
Drug classes of therapeutic agents [br08360.html]
 Antirheumatic and antigout agents
  D00238
Pharmacogenomic biomarkers [br08341.html]
 Polymorphisms and germline mutations
  D00238
BRITE hierarchy
Other DBs
CAS: 446-86-6
PubChem: 7847305
ChEBI: 2948
ChEMBL: CHEMBL1542
DrugBank: DB00993
LigandBox: D00238
NIKKAJI: J2.047H
KCF data Show

ATOM        19
            1   C8y C    22.2600  -23.0300
            2   C8y C    21.0700  -23.7300
            3   S2a S    22.2600  -21.6300
            4   N5x N    23.4500  -23.7300
            5   C8y C    21.0700  -25.1300
            6   N4x N    19.7400  -23.2400
            7   C8y C    21.0700  -20.9300
            8   C8x C    23.4500  -25.1300
            9   N5x N    19.7400  -25.5500
            10  N5x N    22.2600  -25.8300
            11  C8x C    18.9000  -24.4300
            12  C8y C    21.0700  -19.5300
            13  O3a O    23.5200  -19.5300 #-
            14  N2b N    22.2600  -18.8300 #+
            15  N5x N    19.7400  -19.1100
            16  C8x C    18.9000  -20.2300
            17  N4y N    19.7400  -21.3500
            18  O3a O    22.2600  -17.4300
            19  C1a C    18.5276  -22.0500
BOND        21
            1     1   2 1
            2     1   3 1
            3     1   4 2
            4     2   5 2
            5     2   6 1
            6     3   7 1
            7     4   8 1
            8     5   9 1
            9     5  10 1
            10    6  11 1
            11    8  10 2
            12    9  11 2
            13    7  12 2
            14   13  14 1
            15   12  14 1
            16   12  15 1
            17   15  16 2
            18   16  17 1
            19    7  17 1
            20   14  18 2
            21   17  19 1

» Japanese version   » Back

KEGG   DRUG: Azathioprine sodiumHelp
Entry
D03033                      Drug                                   

Name
Azathioprine sodium (USP);
Imuran (TN)
Product
  Generic
Formula
C9H7N7O2S. Na
Exact mass
300.028
Mol weight
300.2523
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Anti-inflammatory
 DG01985  Disease modifying anti-rheumatic drugs (DMARDs)
Remark
ATC code: L04AX01
Chemical structure group: DG00743
Product (DG00743): D00238<JP/US> D03033<US>
Efficacy
Immunosuppressant
Interaction
Drug interaction
Structure map
map07046  Immunosuppressive agents
map07050  Antirheumatics - DMARDs and biological agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L04 IMMUNOSUPPRESSANTS
   L04A IMMUNOSUPPRESSANTS
    L04AX Other immunosuppressants
     L04AX01 Azathioprine
      D03033  Azathioprine sodium (USP) <US>
USP drug classification [BR:br08302]
 Immunological Agents
  Immune Suppressants
   Azathioprine
    D03033  Azathioprine sodium (USP)
BRITE hierarchy
Other DBs
CAS: 55774-33-9
PubChem: 17397188
DrugBank: DB00993
LigandBox: D03033
KCF data Show

ATOM        20
            1   Z   Na   22.1200  -19.1100
            2   C8y C    18.8426  -17.5830
            3   C8y C    17.6519  -18.2834
            4   S2a S    18.8426  -16.1822
            5   N5x N    20.0333  -18.2834
            6   C8y C    17.6519  -19.6842
            7   N4x N    16.3211  -17.7931
            8   C8y C    17.6519  -15.4818
            9   C8x C    20.0333  -19.6842
            10  N5x N    16.3211  -20.1044
            11  N5x N    18.8426  -20.3846
            12  C8x C    15.4807  -18.9838
            13  C8y C    17.6519  -14.0810
            14  O3a O    20.1033  -14.0810 #-
            15  N2b N    18.8426  -13.3806 #+
            16  N5x N    16.3211  -13.6608
            17  C8x C    15.4807  -14.7814
            18  N4y N    16.3211  -15.9021
            19  O3a O    18.8426  -11.9798
            20  C1a C    15.1080  -16.6025
BOND        21
            1     2   3 1
            2     2   4 1
            3     2   5 2
            4     3   6 2
            5     3   7 1
            6     4   8 1
            7     5   9 1
            8     6  10 1
            9     6  11 1
            10    7  12 1
            11    9  11 2
            12   10  12 2
            13    8  13 2
            14   14  15 1
            15   13  15 1
            16   13  16 1
            17   16  17 2
            18   17  18 1
            19    8  18 1
            20   15  19 2
            21   18  20 1

» Japanese version   » Back

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