KEGG   DRUG: ColistinHelp
Entry
D07746                      Drug                                   

Name
Colistin (INN);
CL;
Sogecoli (TN)
Formula
C52H97N16O13R
Structure
Mol fileKCF fileDB search
Source
Bacillus polymyxa var. colistinus
Class
Antibacterial
 DG01579  Polypeptide antibiotic
Remark
ATC code: A07AA10 J01XB01
Chemical structure group: DG00087
Product (DG00087): D02049<JP/US>
Efficacy
Antibacterial, Cell membrane function inhibitor
Comment
Natural product
Polypeptide
Target
Lipopolysaccharide
Interaction
Drug interaction
Other map
map01501  beta-Lactam resistance
map01503  Cationic antimicrobial peptide (CAMP) resistance
map02020  Two-component system
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A07 ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS
   A07A INTESTINAL ANTIINFECTIVES
    A07AA Antibiotics
     A07AA10 Colistin
      D07746  Colistin (INN)
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J01 ANTIBACTERIALS FOR SYSTEMIC USE
   J01X OTHER ANTIBACTERIALS
    J01XB Polymyxins
     J01XB01 Colistin
      D07746  Colistin (INN)
Risk category of Japanese OTC drugs [BR:br08312]
 Second-class OTC drugs
  Inorganic and organic chemicals
   Colistin
    D07746  Colistin (INN)
BRITE hierarchy
Other DBs
CAS: 1066-17-7
PubChem: 51092040
DrugBank: DB00803
NIKKAJI: J861C
KCF data Show

ATOM        82
            1   C1c C    34.4400  -24.2900
            2   C1a C    35.6300  -24.9900
            3   O1a O    33.1800  -24.9900
            4   C1c C    30.8000  -16.3800
            5   N1b N    30.8000  -17.7800
            6   N1b N    33.1800  -16.3800
            7   C5a C    31.9900  -15.6800
            8   C5a C    35.6300  -16.3800
            9   C1c C    34.4400  -15.6800
            10  C1c C    38.0800  -16.3800
            11  N1b N    36.8200  -15.6800
            12  C5a C    29.5400  -18.4100
            13  C1c C    29.5400  -19.8100
            14  C1b C    30.8000  -20.5800
            15  C1b C    30.8000  -21.9800
            16  N1b N    31.9900  -22.6100
            17  C5a C    33.1800  -21.9800
            18  C1c C    34.4400  -22.6100
            19  N1b N    35.6300  -21.9800
            20  C5a C    36.8200  -22.6100
            21  C1c C    38.0800  -21.9800
            22  O5a O    31.9900  -14.2800
            23  C1c C    40.4600  -16.3800
            24  C1b C    39.2700  -15.6800
            25  C1b C    34.4400  -14.0000
            26  C5a C    38.0800  -17.7800
            27  C1a C    41.7200  -15.6800
            28  C1a C    40.4600  -17.7800
            29  O5a O    36.8200  -18.4100
            30  C1c C    35.6300  -13.3000
            31  C1a C    36.8900  -14.0000
            32  C1a C    35.6300  -11.8300
            33  O5a O    35.6300  -17.7800
            34  C1b C    29.5400  -15.6800
            35  O5a O    28.3500  -17.7800
            36  N1b N    28.3500  -20.5800
            37  O5a O    33.1800  -20.5800
            38  O5a O    36.8200  -24.0100
            39  N1b N    38.0800  -20.5800
            40  C5a C    39.4800  -20.5800
            41  N1b N    39.2700  -18.4100
            42  C1c C    40.1800  -19.3900
            43  C1b C    41.5800  -19.3900
            44  C1b C    39.2700  -22.6100
            45  C1b C    39.2700  -24.0100
            46  N1a N    40.4600  -24.7100
            47  C1b C    29.5400  -14.2800
            48  N1a N    28.3500  -13.5800
            49  C5a C    27.1600  -19.8100
            50  C1c C    25.9000  -20.5800
            51  N1b N    24.7100  -19.8100
            52  C5a C    23.5200  -20.5800
            53  C1c C    22.2600  -19.8100
            54  N1b N    21.0700  -20.5800
            55  C5a C    19.8800  -19.8100
            56  C1c C    18.6200  -20.5800
            57  N1b N    17.4300  -19.8100
            58  C5a C    16.2400  -20.5800
            59  C1b C    15.0500  -19.8100
            60  C1b C    13.7900  -20.5800
            61  C1b C    12.6000  -19.8100
            62  C1b C    11.3400  -20.5800
            63  C1c C    10.1500  -19.8100
            64  C1b C     8.9600  -20.5800
            65  R   R     7.7700  -19.8100
            66  O5a O    27.1600  -18.4100
            67  C1b C    25.9000  -21.9800
            68  O5a O    23.5200  -21.9800
            69  C1c C    22.2600  -18.0600
            70  C1a C    21.0700  -17.4300
            71  O1a O    23.5200  -17.4300
            72  O5a O    19.8800  -18.4100
            73  C1b C    18.6200  -21.9800
            74  O5a O    16.2400  -21.9800
            75  C1a C    10.1500  -18.4100
            76  C1b C    24.7100  -22.6100
            77  N1a N    24.7100  -24.0100
            78  C1b C    17.4300  -22.6100
            79  N1a N    17.4300  -24.0100
            80  O5a O    40.1800  -21.7700
            81  C1b C    42.2800  -20.5800
            82  N1a N    43.6800  -20.5800
BOND        82
            1     1   2 1
            2     1   3 1
            3    17  18 1
            4    18  19 1
            5    19  20 1
            6    20  21 1
            7     7  22 2
            8    23  24 1
            9    10  24 1
            10    9  25 1
            11   10  26 1
            12   23  27 1
            13   23  28 1
            14   26  29 2
            15   25  30 1
            16   30  31 1
            17   30  32 1
            18    8  33 2
            19    4  34 1
            20   12  35 2
            21   13  36 1
            22   17  37 2
            23   20  38 2
            24   21  39 1
            25   39  40 1
            26   26  41 1
            27   40  42 1
            28   41  42 1
            29   42  43 1
            30   21  44 1
            31   44  45 1
            32   45  46 1
            33   34  47 1
            34   47  48 1
            35   36  49 1
            36   49  50 1
            37   50  51 1
            38   51  52 1
            39   52  53 1
            40   53  54 1
            41   54  55 1
            42   55  56 1
            43   56  57 1
            44   57  58 1
            45   58  59 1
            46   59  60 1
            47   60  61 1
            48   61  62 1
            49   62  63 1
            50   63  64 1
            51   64  65 1
            52   49  66 2
            53   50  67 1
            54   52  68 2
            55   53  69 1
            56   69  70 1
            57   69  71 1
            58   55  72 2
            59   56  73 1
            60   58  74 2
            61   63  75 1
            62   67  76 1
            63   76  77 1
            64   73  78 1
            65   78  79 1
            66   40  80 2
            67    4   5 1
            68    6   7 1
            69    4   7 1
            70    8   9 1
            71    6   9 1
            72   10  11 1
            73    8  11 1
            74    5  12 1
            75   12  13 1
            76   13  14 1
            77   14  15 1
            78   15  16 1
            79   16  17 1
            80    1  18 1
            81   43  81 1
            82   81  82 1

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