KEGG   DRUG: Tobramycin
Entry
D00063                      Drug                                   

Name
Tobramycin (JP17/USP);
Tobi (TN);
Tobracin (TN);
Tobrex (TN);
Bethkis (TN)
Product
  Generic
TOBRAMYCIN (A-S Medication Solutions), TOBRAMYCIN (A-S Medication Solutions), TOBRAMYCIN (A-S Medication Solutions), TOBRAMYCIN (Akorn), TOBRAMYCIN (Akorn), TOBRAMYCIN (Amneal Pharmaceuticals LLC), TOBRAMYCIN (Asclemed USA), TOBRAMYCIN (Aurobindo Pharma Limited), TOBRAMYCIN (Bausch & Lomb Incorporated), TOBRAMYCIN (DirectRX), TOBRAMYCIN (Genericus), TOBRAMYCIN (Gland Pharma Limited), TOBRAMYCIN (Henry Schein), TOBRAMYCIN (Lupin Pharmaceuticals), TOBRAMYCIN (MWI), TOBRAMYCIN (Medsource Pharmaceuticals), TOBRAMYCIN (Medsource Pharmaceuticals), TOBRAMYCIN (NuCare Pharmaceuticals), TOBRAMYCIN (NuCare Pharmaceuticals), TOBRAMYCIN (NuCare Pharmaceuticals), TOBRAMYCIN (Preferred Pharmaceuticals), TOBRAMYCIN (Proficient Rx LP), TOBRAMYCIN (Proficient Rx LP), TOBRAMYCIN (Proficient Rx LP), TOBRAMYCIN (Proficient Rx LP), TOBRAMYCIN (Quality Care Products), TOBRAMYCIN (REMEDYREPACK), TOBRAMYCIN (RPK Pharmaceuticals), TOBRAMYCIN (RPK Pharmaceuticals), TOBRAMYCIN (RPK Pharmaceuticals), TOBRAMYCIN (RPK Pharmaceuticals), TOBRAMYCIN (Sandoz), TOBRAMYCIN (Sandoz), TOBRAMYCIN (Somerset Therapeutics), TOBRAMYCIN (St. Mary's Medical Park Pharmacy), TOBRAMYCIN (Sun Pharmaceutical Industries), TOBRAMYCIN (Teva Pharmaceuticals USA), TOBRAMYCIN (Teva Pharmaceuticals USA), TOBRAMYCIN INHALATION (Prasco), TOBRAMYCIN INHALATION SOLUTION (Dr. Reddy's Laboratories), TOBRAMYCIN INHALATION SOLUTION (NorthStar RxLLC), TOBRAMYCIN OPHTHALMIC SOLUTION (Alembic Pharmaceuticals)
Formula
C18H37N5O9
Exact mass
467.2591
Mol weight
467.5145
Structure
Simcomp
Source
Streptomyces tenebrarius [TAX:1933]
Class
Antibacterial
 DG01447  Aminoglycoside antibiotic
Remark
Same as: C00397
Therapeutic category: 1317 6123
ATC code: J01GB01 S01AA12
Chemical structure group: DG00608
Product (DG00608): D00063<JP/US> D02542<US>
Product (mixture): D11178<US>
Efficacy
Antibacterial, Protein biosynthesis inhibitor
  Disease
Cystic fibrosis patients with Pseudomonas aeruginosa [DS:H00218]
Target
50S ribosomal subunit
30S ribosomal subunit
  Pathway
ko03010  Ribosome
Interaction
Biosynthesis
map00524  Neomycin, kanamycin and gentamicin biosynthesis
Structure map
map07021  Aminoglycosides
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J01 ANTIBACTERIALS FOR SYSTEMIC USE
   J01G AMINOGLYCOSIDE ANTIBACTERIALS
    J01GB Other aminoglycosides
     J01GB01 Tobramycin
      D00063  Tobramycin (JP17/USP) <JP/US>
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01A ANTIINFECTIVES
    S01AA Antibiotics
     S01AA12 Tobramycin
      D00063  Tobramycin (JP17/USP) <JP/US>
USP drug classification [BR:br08302]
 Antibacterials
  Aminoglycosides
   Tobramycin
    D00063  Tobramycin (JP17/USP)
 Ophthalmic Agents
  Ophthalmic Anti-Infectives
   Antibacterials, Ophthalmic
    Tobramycin
     D00063  Tobramycin (JP17/USP)
 Respiratory Tract/Pulmonary Agents
  Cystic Fibrosis Agents
   Inhaled Anti-infectives
    Tobramycin
     D00063  Tobramycin (JP17/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  13  Agents affecting sensory organs
   131  Ophthalmic agents
    1317  Ophthalmic antibiotics
     D00063  Tobramycin (JP17/USP)
 6  Agents against pathologic organisms and parasites
  61  Antibiotics
   612  Acting mainly on gram-negative bacteria
    6123  Amino sugars
     D00063  Tobramycin (JP17/USP)
Antiinfectives [BR:br08307]
 Antibacterials
  Protein biosynthesis inhibitor
   Aminoglycoside
    D00063  Tobramycin (JP17/USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00063  Tobramycin
  D00063 Tobramycin injection
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D00063
Other DBs
CAS: 32986-56-4
PubChem: 7847131
ChEBI: 28864
ChEMBL: CHEMBL1747
DrugBank: DB00684
PDB-CCD: TOY[PDBj]
LigandBox: D00063
NIKKAJI: J4.533K
KCF data

ATOM        32
            1   C1y C    20.6560  -20.0968
            2   C1y C    20.6560  -21.4973
            3   C1y C    21.8689  -22.1975
            4   C1y C    23.0818  -21.4973
            5   C1y C    23.0818  -20.0968
            6   O2x O    21.8689  -19.3965
            7   C1b C    19.4432  -19.3965
            8   O1a O    18.2473  -20.0872
            9   O1a O    19.4432  -22.1975
            10  N1a N    21.8689  -23.5978
            11  O1a O    24.3134  -22.2085
            12  O2a O    24.3134  -19.3855
            13  C1y C    25.4878  -18.6963
            14  C1y C    26.7056  -19.3879
            15  C1x C    27.9134  -18.6791
            16  C1y C    27.9035  -17.2786
            17  C1y C    26.6857  -16.5869
            18  C1y C    25.4779  -17.2958
            19  N1a N    26.7157  -20.7965
            20  N1a N    29.0779  -16.5893
            21  O1a O    24.2675  -16.6084
            22  O2a O    26.6757  -15.1950
            23  C1y C    27.8854  -14.4851
            24  O2x O    29.0946  -15.1718
            25  C1y C    30.3025  -14.4631
            26  C1y C    30.2926  -13.0626
            27  C1x C    29.0835  -12.3758
            28  C1y C    27.8755  -13.0846
            29  C1b C    31.5468  -15.1693
            30  N1a N    31.5569  -16.5953
            31  O1a O    31.5060  -12.3503
            32  N1a N    26.6567  -12.3923
BOND        34
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     4   5 1
            5     5   6 1
            6     1   6 1
            7     1   7 1 #Up
            8     7   8 1
            9     2   9 1 #Down
            10    3  10 1 #Up
            11    4  11 1 #Down
            12    5  12 1 #Down
            13   13  12 1 #Down
            14   13  14 1
            15   14  15 1
            16   15  16 1
            17   16  17 1
            18   17  18 1
            19   13  18 1
            20   14  19 1 #Up
            21   16  20 1 #Up
            22   18  21 1 #Up
            23   17  22 1 #Down
            24   23  22 1 #Down
            25   23  24 1
            26   24  25 1
            27   25  26 1
            28   26  27 1
            29   27  28 1
            30   23  28 1
            31   25  29 1 #Up
            32   29  30 1
            33   26  31 1 #Down
            34   28  32 1 #Down

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Disease (3)   
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