KEGG   DRUG: Valproic acid
Entry
D00399                      Drug                                   

Name
Valproic acid (USP);
Depakene (TN)
Product
  Generic
VALPROIC ACID (ATLANTIC BIOLOGICALS CORP.), VALPROIC ACID (ATLANTIC BIOLOGICALS CORP.), VALPROIC (Actavis Pharma), VALPROIC ACID (American Health Packaging), VALPROIC ACID (Aphena Pharma Solutions - Tennessee), VALPROIC ACID (Aphena Pharma Solutions - Tennessee), VALPROIC (Aphena Pharma Solutions - Tennessee), VALPROIC (AvKARE), VALPROIC ACID (Bionpharma), VALPROIC (Bryant Ranch Prepack), VALPROIC ACID (Bryant Ranch Prepack), VALPROIC ACID (Direct_Rx), VALPROIC ACID (Eywa Pharma), VALPROIC ACID (Hi-Tech Pharmacal), VALPROIC ACID (Lannett Company), VALPROIC ACID (McKesson Corporation dba SKY Packaging), VALPROIC ACID (McKesson Corporation dba SKY Packaging), VALPROIC ACID (Morton Grove Pharmaceuticals), VALPROIC ACID (NCS HealthCare of KY), VALPROIC ACID (Pharmaceutical Associates), VALPROIC ACID (Precision Dose), VALPROIC ACID (REMEDYREPACK), VALPROIC ACID (Upsher-Smith Laboratories)
Formula
C8H16O2
Exact mass
144.115
Mol weight
144.2114
Structure
Simcomp
Class
Cardiovascular agent
 DG01575  Calcium channel blocker
  DG01573  Calcium channel T type blocker
Neuropsychiatric agent
 DG03199  Antiepileptic agent
  DG02035  Fatty acid antiepileptic
Remark
Same as: C07185
ATC code: N03AG01
Chemical structure group: DG00849
Product (DG00849): D00399<US> D00304<US> D00710<JP/US>
Efficacy
Anticonvulsant
Comment
Fatty acid derivative
Valproic acid is contraindicated in patients with known urea cycle disorders [DS:H00164 H00185 H00186 H00187 H01028 H01032]
Target
ABAT [HSA:18] [KO:K13524]
SSADH [HSA:7915] [KO:K00139]
GAD [HSA:2571 2572] [KO:K01580]
CACNA1-T [HSA:8911 8912 8913] [KO:K04856 K04855 K04854]
  Pathway
hsa04020  Calcium signaling pathway
hsa04727  GABAergic synapse
Interaction
Structure map
map07033  Anticonvulsants
map07036  Calcium channel blocking drugs
map07048  Antimigraines
Other map
map00982  Drug metabolism - cytochrome P450
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N03 ANTIEPILEPTICS
   N03A ANTIEPILEPTICS
    N03AG Fatty acid derivatives
     N03AG01 Valproic acid
      D00399  Valproic acid (USP) <US>
USP drug classification [BR:br08302]
 Anticonvulsants
  Anticonvulsants, Other
   Multiple MoA
    Valproic Acid
     D00399  Valproic acid (USP)
 Antimigraine Agents
  Antimigraine Agents, Other
   Valproic Acid
    D00399  Valproic acid (USP)
 Bipolar Agents
  Mood Stabilizers
   Valproic Acid
    D00399  Valproic acid (USP)
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01575  Calcium channel blocker
   DG01573  Calcium channel T type blocker
    DG00849  Valproic acid
     D00399  Valproic acid
 Neuropsychiatric agent
  DG03199  Antiepileptic agent
   DG02035  Fatty acid antiepileptic
    DG00849  Valproic acid
     D00399  Valproic acid
Drug classes [BR:br08332]
 Cardiovascular agent
  DG01575  Calcium channel blocker
   D00399  Valproic acid
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated ion channels
   Calcium channels
    CACNA1-T
     D00399  Valproic acid (USP) <US>
 Enzymes
  Oxidoreductases (EC1)
   Dehydrogenases
    SSADH
     D00399  Valproic acid (USP) <US>
  Transferases (EC2)
   Aminotransferase
    ABAT
     D00399  Valproic acid (USP) <US>
  Lyases (EC4)
   Carboxy-lyases
    GAD
     D00399  Valproic acid (USP) <US>
Pharmacogenomic biomarkers [br08341.html]
 Polymorphisms and mutations affecting drug response
  D00399
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01575  Calcium channel blocker
   DG01573  Calcium channel T type blocker
    DG00849  Valproic acid
 Neuropsychiatric agent
  DG03199  Antiepileptic agent
   DG02035  Fatty acid antiepileptic
    DG00849  Valproic acid
Other DBs
CAS: 99-66-1
PubChem: 7847465
ChEBI: 39867
ChEMBL: CHEMBL109
DrugBank: DB00313
PDB-CCD: 2PP[PDBj]
LigandBox: D00399
NIKKAJI: J4.972G
KCF data

ATOM        10
            1   C1c C    25.4573  -18.6784
            2   C1b C    25.4573  -17.3002
            3   C1b C    24.2485  -19.3967
            4   C6a C    26.6604  -19.3967
            5   C1b C    24.2427  -16.5935
            6   C1b C    23.0396  -18.6784
            7   O6a O    26.6604  -20.7925
            8   O6a O    27.8692  -18.6784
            9   C1a C    23.0339  -17.3002
            10  C1a C    21.8367  -19.3967
BOND        9
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     3   6 1
            6     4   7 1
            7     4   8 2
            8     5   9 1
            9     6  10 1

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