| Entry |
|
|---|
| Name |
Prochlorperazine maleate (JP18/USP);
Compazine (TN) |
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| Product |
|
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| Generic |
PROCHLORPERAZINE (PharmPak), PROCHLORPERAZINE (PharmPak), PROCHLORPERAZINE MALEATE (A-S Medication Solutions), PROCHLORPERAZINE MALEATE (Amneal Pharmaceuticals NY LLC), PROCHLORPERAZINE MALEATE (AvPAK), PROCHLORPERAZINE MALEATE (Bionpharma), PROCHLORPERAZINE MALEATE (Bryant Ranch Prepack), PROCHLORPERAZINE MALEATE (Cadila Healthcare Limited), PROCHLORPERAZINE MALEATE (Cardinal Health 107), PROCHLORPERAZINE MALEATE (Direct_Rx), PROCHLORPERAZINE MALEATE (GLENMARK PHARMACEUTICALS), PROCHLORPERAZINE MALEATE (JUBILANT CADISTA PHARMACEUTICALS), PROCHLORPERAZINE MALEATE (Northstar Rx LLC), PROCHLORPERAZINE MALEATE (Northwind Pharmaceuticals), PROCHLORPERAZINE MALEATE (Novitium Pharma LLC), PROCHLORPERAZINE MALEATE (PD-Rx Pharmaceuticals), PROCHLORPERAZINE MALEATE (Preferred Pharmaceuticlas), PROCHLORPERAZINE MALEATE (Proficient Rx LP), PROCHLORPERAZINE MALEATE (QPharma), PROCHLORPERAZINE MALEATE (REMEDYREPACK), PROCHLORPERAZINE MALEATE (RedPharm Drug), PROCHLORPERAZINE MALEATE (Zydus Pharmaceuticals (USA)) |
|---|
| Formula |
C20H24ClN3S. (C4H4O4)2
|
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| Exact mass |
605.1599
|
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| Mol weight |
606.087
|
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| Structure |
|
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| Simcomp |
|
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| Class |
Neuropsychiatric agent
DG01478 Dopamine antagonist
DG01474 Dopamine D2-receptor antagonist
DG03200 Antipsychotic agent
DG01905 Phenothiazine antipsychotics
|
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| Remark |
| Therapeutic category: | 1172 |
| Product (DG00876): | D00493<US> D00479<JP/US> D02022<JP> D02609<US> |
|
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| Efficacy |
Antipsychotic, Anti-emetic, Dopamine D2 receptor antagonist |
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| Disease |
|
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| Comment |
Phenothiazine derivative
|
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| Target |
|
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| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
|
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| Interaction |
|
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| Structure map |
| map07029 | Antipsychotics - phenothiazines |
|
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
N05 PSYCHOLEPTICS
N05A ANTIPSYCHOTICS
N05AB Phenothiazines with piperazine structure
N05AB04 Prochlorperazine
D00479 Prochlorperazine maleate (JP18/USP) <JP/US>
USP drug classification [BR:br08302]
Antiemetics
Antiemetics, Other
Prochlorperazine
D00479 Prochlorperazine maleate (JP18/USP)
Antipsychotics
1st Generation/Typical
Prochlorperazine
D00479 Prochlorperazine maleate (JP18/USP)
Therapeutic category of drugs in Japan [BR:br08301]
1 Agents affecting nervous system and sensory organs
11 Agents affecting central nervous system
117 Psychotropics
1172 Phenothiazines
D00479 Prochlorperazine maleate (JP18/USP)
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01478 Dopamine antagonist
DG01474 Dopamine D2-receptor antagonist
DG00876 Prochlorperazine
D00479 Prochlorperazine maleate
DG03200 Antipsychotic agent
DG01905 Phenothiazine antipsychotics
DG00876 Prochlorperazine
D00479 Prochlorperazine maleate
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Dopamine
DRD2
D00479 Prochlorperazine maleate (JP18/USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D00479 Prochlorperazine maleate
D00479 Prochlorperazine maleate tablets
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01478 Dopamine antagonist
DG01474 Dopamine D2-receptor antagonist
DG00876 Prochlorperazine
DG03200 Antipsychotic agent
DG01905 Phenothiazine antipsychotics
DG00876 Prochlorperazine
|
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| Other DBs |
|
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| KCF data |
ATOM 41
1 C2b C 39.0699 -17.9328
2 C2b C 37.4396 -17.9386
3 C6a C 39.7454 -19.1089
4 C6a C 36.7699 -19.1205
5 O6a O 39.0756 -20.2792
6 O6a O 41.1078 -19.0915
7 O6a O 35.4074 -19.1205
8 O6a O 37.4510 -20.2909
9 C8x C 22.1200 -19.3900
10 C8x C 22.1200 -20.7900
11 C8x C 23.3100 -21.4900
12 C8y C 24.5700 -20.7900
13 C8y C 24.5700 -19.3900
14 C8x C 23.3100 -18.6900
15 S2x S 25.7600 -21.4900
16 C8y C 26.9500 -20.7900
17 C8y C 26.9500 -19.3900
18 N4y N 25.7600 -18.6900
19 C8x C 28.2100 -21.4900
20 C8x C 29.4000 -20.7900
21 C8y C 29.4000 -19.3900
22 C8x C 28.2100 -18.6900
23 C1b C 25.7600 -17.2900
24 X Cl 30.5900 -18.6900
25 C1b C 26.9500 -16.5900
26 C1b C 28.1400 -17.2900
27 N1y N 29.3300 -16.5900
28 C1x C 30.5200 -17.2900
29 C1x C 31.7800 -16.5900
30 N1y N 31.7800 -15.1900
31 C1x C 30.5900 -14.4900
32 C1x C 29.3300 -15.1900
33 C1a C 32.9700 -14.4900
34 C2b C 39.0699 -17.9328
35 C2b C 37.4396 -17.9386
36 C6a C 36.7699 -19.1205
37 O6a O 35.4074 -19.1205
38 O6a O 37.4510 -20.2909
39 C6a C 39.7454 -19.1089
40 O6a O 39.0756 -20.2792
41 O6a O 41.1078 -19.0915
BOND 42
1 9 10 2
2 10 11 1
3 11 12 2
4 12 13 1
5 13 14 2
6 9 14 1
7 12 15 1
8 15 16 1
9 16 17 1
10 17 18 1
11 13 18 1
12 16 19 2
13 19 20 1
14 20 21 2
15 21 22 1
16 17 22 2
17 18 23 1
18 21 24 1
19 23 25 1
20 25 26 1
21 26 27 1
22 27 28 1
23 28 29 1
24 29 30 1
25 30 31 1
26 31 32 1
27 27 32 1
28 30 33 1
29 1 2 2
30 1 3 1
31 2 4 1
32 3 5 1
33 3 6 2
34 4 7 1
35 4 8 2
36 34 35 2
37 34 39 1
38 35 36 1
39 39 40 1
40 39 41 2
41 36 37 1
42 36 38 2
BRACKET 1 34.1600 -21.1400 34.1600 -16.9400
1 41.6500 -16.9400 41.6500 -21.1400
1 2
ORIGINAL 1 1 2 4 7 8 3 5 6
REPEAT 1 34 35 36 37 38 39 40 41
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