| Entry |
|
|---|
| Name |
Pilocarpine (JAN/USP);
Ocusert pilo-20 (TN) |
|---|
| Formula |
C11H16N2O2
|
|---|
| Exact mass |
208.1212
|
|---|
| Mol weight |
208.2569
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Source |
|
|---|
| Class |
Neuropsychiatric agent
DG01490 Muscarinic cholinergic receptor agonist
Other
DG01719 Parasympathomimetic agent
Metabolizing enzyme substrate
DG01638 CYP2A6 substrate
|
|---|
| Remark |
| Product (DG00992): | D02200<JP/US> |
|
|---|
| Efficacy |
Antiglaucoma, Muscarinic acetylcholine receptor agonist |
|---|
| Target |
|
|---|
| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
|
|---|
| Metabolism |
Enzyme: CYP2A6 [HSA: 1548]
|
|---|
| Interaction |
|
|---|
| Structure map |
| map07220 | Cholinergic and anticholinergic drugs |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
N07 OTHER NERVOUS SYSTEM DRUGS
N07A PARASYMPATHOMIMETICS
N07AX Other parasympathomimetics
N07AX01 Pilocarpine
D00525 Pilocarpine (JAN/USP)
S SENSORY ORGANS
S01 OPHTHALMOLOGICALS
S01E ANTIGLAUCOMA PREPARATIONS AND MIOTICS
S01EB Parasympathomimetics
S01EB01 Pilocarpine
D00525 Pilocarpine (JAN/USP)
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Acetylcholine (muscarinic)
CHRM2
D00525 Pilocarpine (JAN/USP)
CHRM3
D00525 Pilocarpine (JAN/USP)
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D00525
|
|---|
| Other DBs |
|
|---|
| KCF data |
ATOM 15
1 C1y C 24.1199 -19.7000
2 C1y C 22.7112 -19.7000
3 C1b C 25.3415 -20.3431
4 C1x C 24.5641 -18.3555
5 C7x C 22.2729 -18.3555
6 C1b C 21.8810 -20.8399
7 C8y C 26.4112 -19.7058
8 O7x O 23.4185 -17.5255
9 O6a O 20.9284 -17.9171
10 C1a C 20.4782 -20.8338
11 N4y N 27.8257 -19.7058
12 C8x C 25.9670 -18.3614
13 C8x C 28.2584 -18.3614
14 C1a C 28.6499 -20.8456
15 N5x N 27.1186 -17.5313
BOND 16
1 1 2 1
2 1 3 1 #Down
3 1 4 1
4 2 5 1
5 2 6 1 #Down
6 3 7 1
7 4 8 1
8 5 9 2
9 6 10 1
10 7 11 1
11 7 12 2
12 11 13 1
13 11 14 1
14 12 15 1
15 5 8 1
16 13 15 2
|
|---|
