KEGG   DRUG: Colchicine
Entry
D00570                      Drug                                   

Name
Colchicine (JP18/USP);
Colchicine (TN)
Product
  Generic
COLCHICINE (Actavis Pharma), COLCHICINE (American Health Packaging), COLCHICINE (Amneal Pharmaceuticals LLC), COLCHICINE (Aphena Pharma Solutions - Tennessee), COLCHICINE (Ascend Laboratories), COLCHICINE (AvPAK), COLCHICINE (Bryant Ranch Prepack), COLCHICINE (Bryant Ranch Prepack), COLCHICINE (Bryant Ranch Prepack), COLCHICINE (Bryant Ranch Prepack), COLCHICINE (Bryant Ranch Prepack), COLCHICINE (Bryant Ranch Prepack), COLCHICINE (Bryant Ranch Prepack), COLCHICINE (Camber Pharmaceuticals), COLCHICINE (Dr.Reddys Laboratories), COLCHICINE (Golden State Medical Supply), COLCHICINE (Granules Pharmaceuticals), COLCHICINE (Major Pharmaceuticals), COLCHICINE (Mylan Institutional), COLCHICINE (Mylan Pharmaceuticals), COLCHICINE (Northstar Rx LLC.), COLCHICINE (NuCare Pharmaceuticals), COLCHICINE (Par Pharmaceutical), COLCHICINE (Proficient Rx LP), COLCHICINE (RedPharm Drug), COLCHICINE (Zydus Pharmaceuticals (USA))
Formula
C22H25NO6
Exact mass
399.1682
Mol weight
399.437
Structure
Simcomp
Source
Colchicum autumnale [TAX:45005]
Class
Metabolizing enzyme substrate
 DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate
Transporter substrate
 DG01665  ABCB1 substrate
Remark
Same as: C07592
Therapeutic category: 3941
ATC code: M04AC01
Product: D00570<JP/US>
Product (mixture): D11574<US>
Efficacy
Gout suppressant, Leukocyte (neutrophil) migration inhibitor, Tubulin polymerization inhibitor
  Disease
Gout flares [DS:H01532]
Familial mediterranean fever [DS:H00288]
Target
  Pathway
hsa04145  Phagosome
hsa04540  Gap junction
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Transporter: ABCB1 [HSA:5243]
Interaction
Other map
map04976  Bile secretion
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 M MUSCULO-SKELETAL SYSTEM
  M04 ANTIGOUT PREPARATIONS
   M04A ANTIGOUT PREPARATIONS
    M04AC Preparations with no effect on uric acid metabolism
     M04AC01 Colchicine
      D00570  Colchicine (JP18/USP) <JP/US>
USP drug classification [BR:br08302]
 Antigout Agents
  Colchicine
   D00570  Colchicine (JP18/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 3  Agents affecting metabolism
  39  Other agents affecting metabolism
   394  Gout preparations
    3941  Colchicines
     D00570  Colchicine (JP18/USP)
Drug groups [BR:br08330]
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    D00570  Colchicine
 Transporter substrate
  DG01665  ABCB1 substrate
   D00570  Colchicine
Target-based classification of drugs [BR:br08310]
 Not elsewhere classified
  Cellular process
   Cytoskeleton
    TUBB
     D00570  Colchicine (JP18/USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00570  Colchicine
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D00570
 Drug transporters
  D00570
Other DBs
CAS: 64-86-8
PubChem: 7847636
ChEBI: 27882
ChEMBL: CHEMBL107
DrugBank: DB01394
PDB-CCD: LOC[PDBj]
LigandBox: D00570
NIKKAJI: J9.267C
KCF data

ATOM        29
            1   C1x C    24.2475  -17.8137
            2   C8y C    23.4044  -16.6895
            3   C8y C    23.7557  -15.3545
            4   C1x C    25.6528  -17.8137
            5   C2y C    26.2852  -15.4247
            6   C1y C    26.5662  -16.7597
            7   C8y C    22.7018  -14.3708
            8   C8y C    21.3668  -14.7924
            9   C8y C    21.0155  -16.1274
            10  C8x C    22.0695  -17.1111
            11  O2a O    22.9829  -12.9655
            12  O2a O    20.3832  -13.8087
            13  O2a O    19.6805  -16.5489
            14  C2y C    25.0493  -14.7557
            15  C2x C    24.7813  -13.3322
            16  C2x C    25.7259  -12.3957
            17  C2y C    27.1392  -12.3715
            18  C5x C    27.9503  -13.5297
            19  C2x C    27.5618  -14.8375
            20  C1a C    18.6440  -15.6000
            21  C1a C    20.7468  -12.4513
            22  C1a C    24.3140  -12.5152
            23  O5x O    29.3583  -13.5117
            24  O2a O    27.7924  -11.1650
            25  C1a C    29.1660  -11.1268
            26  N1b N    27.9266  -17.1119
            27  C5a C    29.1058  -16.3874
            28  C1a C    30.3325  -17.0465
            29  O5a O    29.1329  -14.9842
BOND        31
            1     1   4 1
            2     2   3 1
            3     4   6 1
            4     1   2 1
            5     5   6 1
            6     3   7 2
            7     7   8 1
            8     8   9 2
            9     9  10 1
            10    2  10 2
            11    7  11 1
            12    8  12 1
            13    9  13 1
            14   16  17 2
            15   17  18 1
            16   15  16 1
            17    5  19 2
            18   14  15 2
            19   18  19 1
            20    3  14 1
            21   14   5 1
            22   13  20 1
            23   12  21 1
            24   11  22 1
            25   18  23 2
            26   17  24 1
            27   24  25 1
            28    6  26 1 #Up
            29   26  27 1
            30   27  28 1
            31   27  29 2

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