KEGG   DRUG: Isosorbide mononitrate
Entry
D00630                      Drug                                   

Name
Isosorbide mononitrate (JP18/USP/INN);
Imdur (TN);
Ismo (TN)
Product
  Generic
ISOSORBIDE MONONITRATE (A-S Medication Solutions), ISOSORBIDE MONONITRATE (A-S Medication Solutions), ISOSORBIDE MONONITRATE (A-S Medication Solutions), ISOSORBIDE MONONITRATE (A-S Medication Solutions), ISOSORBIDE MONONITRATE (Actavis Pharma), ISOSORBIDE MONONITRATE (American Health Packaging), ISOSORBIDE MONONITRATE (Aphena Pharma Solutions - Tennessee), ISOSORBIDE MONONITRATE (Aphena Pharma Solutions - Tennessee), ISOSORBIDE MONONITRATE (Aphena Pharma Solutions - Tennessee), ISOSORBIDE MONONITRATE (Aphena Pharma Solutions - Tennessee), ISOSORBIDE MONONITRATE (AvPAK), ISOSORBIDE MONONITRATE (Bryant Ranch Prepack), ISOSORBIDE MONONITRATE (Bryant Ranch Prepack), ISOSORBIDE MONONITRATE (Cardinal Health), ISOSORBIDE MONONITRATE (Cardinal Health), ISOSORBIDE MONONITRATE (Golden State Medical Supply), ISOSORBIDE MONONITRATE (Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals), ISOSORBIDE MONONITRATE (Ingenus Pharmaceuticals), ISOSORBIDE MONONITRATE (Lannett Company), ISOSORBIDE MONONITRATE (Lannett Company), ISOSORBIDE MONONITRATE (Major Pharmaceuticals), ISOSORBIDE MONONITRATE (NCS HealthCare of KY), ISOSORBIDE MONONITRATE (NuCare Pharmaceuticals), ISOSORBIDE MONONITRATE (NuCare Pharmaceuticals), ISOSORBIDE (NuCare Pharmaceuticals), ISOSORBIDE (NuCare Pharmaceuticals), ISOSORBIDE MONONITRATE (PD-Rx Pharmaceuticals), ISOSORBIDE MONONITRATE (Proficient Rx LP), ISOSORBIDE MONONITRATE (Proficient Rx LP), ISOSORBIDE MONONITRATE (REMEDYREPACK), ISOSORBIDE MONONITRATE (REMEDYREPACK), ISOSORBIDE MONONITRATE (REMEDYREPACK), ISOSORBIDE MONONITRATE (REMEDYREPACK), ISOSORBIDE MONONITRATE (REMEDYREPACK), ISOSORBIDE MONONITRATE (REMEDYREPACK), ISOSORBIDE MONONITRATE (REMEDYREPACK), ISOSORBIDE MONONITRATE (REMEDYREPACK), ISOSORBIDE MONONITRATE (RPK Pharmaceuticals), ISOSORBIDE MONONITRATE (Torrent Pharmaceuticals Limited), ISOSORBIDE MONONITRATE (Zydus Pharmaceuticals (USA)), ISOSORBIDE MONONITRATE ER (Direct Rx), TIMOLOL MALEATE (Akorn)
Formula
C6H9NO6
Exact mass
191.043
Mol weight
191.1388
Structure
Simcomp
Class
Cardiovascular agent
 DG01657  Nitrovasodilator
Remark
Same as: C07714
Therapeutic category: 2171
ATC code: C01DA14
Chemical structure group: DG01270
Product (DG01270): D00516<JP/US> D00630<JP/US>
Efficacy
Vasodilator (coronary)
  Disease
Angina pectoris [DS:H01632]
Comment
Organic nitrate
Osmotic diuretic
Nitric oxide donor
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C01 CARDIAC THERAPY
   C01D VASODILATORS USED IN CARDIAC DISEASES
    C01DA Organic nitrates
     C01DA14 Isosorbide mononitrate
      D00630  Isosorbide mononitrate (JP18/USP/INN) <JP/US>
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Vasodilators
   Direct-acting Arterial/Venous
    Isosorbide Mononitrate
     D00630  Isosorbide mononitrate (JP18/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   217  Vasodilators
    2171  Coronary dilators
     D00630  Isosorbide mononitrate (JP18/USP/INN)
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01657  Nitrovasodilator
   DG01270  Isosorbide nitrate
    D00630  Isosorbide mononitrate
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00630  Isosorbide mononitrate tablets
Pharmacogenomic biomarkers [br08341.html]
 Polymorphisms and mutations affecting drug response
  D00630
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01657  Nitrovasodilator
   DG01270  Isosorbide nitrate
Other DBs
CAS: 16051-77-7
PubChem: 7847696
ChEBI: 6062
ChEMBL: CHEMBL1311
DrugBank: DB01020
LigandBox: D00630
NIKKAJI: J22.753F
KCF data

ATOM        13
            1   C1y C    32.1300  -17.9200
            2   C1y C    32.1300  -16.5200
            3   C1y C    30.8000  -16.1000
            4   C1x C    30.0300  -17.2200
            5   O2x O    30.8000  -18.3400
            6   C1y C    33.4600  -18.3400
            7   C1x C    34.2300  -17.2200
            8   O2x O    33.4600  -16.1000
            9   O2a O    33.8100  -19.6700
            10  O1a O    30.3800  -14.7700
            11  N2b N    35.2100  -19.6700 #+
            12  O3a O    35.9100  -20.8600 #-
            13  O3a O    35.9100  -18.3400
BOND        14
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     4   5 1
            5     1   5 1
            6     1   6 1
            7     6   7 1
            8     7   8 1
            9     2   8 1
            10    6   9 1 #Up
            11    3  10 1 #Down
            12    9  11 1
            13   11  12 1
            14   11  13 2

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