KEGG   DRUG: Loxapine succinate
Entry
D00794                      Drug                                   

Name
Loxapine succinate (USP);
Loxitane (TN)
Product
  Generic
Formula
C18H18ClN3O. C4H6O4
Exact mass
445.1404
Mol weight
445.8961
Structure
Class
Neuropsychiatric agent
 DG01478  Dopamine antagonist
  DG01474  Dopamine D2-receptor antagonist
Metabolizing enzyme substrate
 DG01892  CYP1A2 substrate
 DG01644  CYP2D6 substrate
 DG02913  CYP3A4 substrate
Remark
ATC code: N05AH01
Chemical structure group: DG00897
Product (DG00897): D02340<US> D00794<US>
Efficacy
Minor tranquilizer, Dopamine D2 receptor antagonist, Serotonin receptor antagonist
  Disease
Schizophrenia [DS:H01649]
Target
DRD2 [HSA:1813] [KO:K04145]
HTR2A [HSA:3356] [KO:K04157]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04726  Serotonergic synapse
hsa04728  Dopaminergic synapse
Metabolism
Enzyme: CYP1A2 [HSA:1544], CYP3A4 [HSA:1576], CYP2D6 [HSA:1565]
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N05 PSYCHOLEPTICS
   N05A ANTIPSYCHOTICS
    N05AH Diazepines, oxazepines and thiazepines
     N05AH01 Loxapine
      D00794  Loxapine succinate (USP) <US>
USP drug classification [BR:br08302]
 Antipsychotics
  1st Generation/Typical
   Loxapine
    D00794  Loxapine succinate (USP)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Dopamine
    DRD2
     D00794  Loxapine succinate (USP) <US>
   Serotonin
    HTR2A
     D00794  Loxapine succinate (USP) <US>
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D00794
Other DBs
CAS: 27833-64-3
PubChem: 7847859
ChEBI: 6549
ChEMBL: CHEMBL1201155
DrugBank: DB00408
LigandBox: D00794
NIKKAJI: J262.621G
KCF data

ATOM        31
            1   C6a C    38.6351  -18.6142
            2   C1b C    37.4213  -19.3202
            3   O6a O    39.8548  -19.3202
            4   O6a O    38.6351  -17.2194
            5   C1b C    36.2133  -18.6200
            6   C6a C    35.0053  -19.3260
            7   O6a O    33.7914  -18.6259
            8   O6a O    35.0053  -20.7208
            9   C2y C    28.7700  -17.5000
            10  C8y C    27.9300  -16.3800
            11  C8y C    28.2800  -15.0500
            12  O2x O    29.5400  -14.4900
            13  N2x N    30.1700  -17.5000
            14  C8y C    30.8000  -15.1200
            15  C8y C    31.0800  -16.4500
            16  C8x C    27.2300  -14.0700
            17  C8x C    25.9000  -14.4900
            18  C8y C    25.5500  -15.8200
            19  C8x C    26.6000  -16.8000
            20  C8x C    32.4100  -16.8700
            21  C8x C    33.4600  -15.9600
            22  C8x C    33.1800  -14.5600
            23  C8x C    31.8500  -14.1400
            24  X   Cl   24.2200  -16.2400
            25  N1y N    28.1400  -18.7600
            26  C1x C    26.7400  -18.7600
            27  C1x C    26.0400  -19.9500
            28  N1y N    26.7400  -21.2100
            29  C1x C    28.1400  -21.2100
            30  C1x C    28.8400  -19.9500
            31  C1a C    26.0400  -22.4000
BOND        33
            1     1   2 1
            2     1   3 1
            3     1   4 2
            4     2   5 1
            5     5   6 1
            6     6   7 1
            7     6   8 2
            8    11  12 1
            9     9  13 2
            10   12  14 1
            11   10  11 1
            12   13  15 1
            13    9  10 1
            14   14  15 1
            15   11  16 2
            16   16  17 1
            17   17  18 2
            18   18  19 1
            19   10  19 2
            20   15  20 2
            21   20  21 1
            22   21  22 2
            23   22  23 1
            24   14  23 2
            25   18  24 1
            26    9  25 1
            27   25  26 1
            28   26  27 1
            29   27  28 1
            30   28  29 1
            31   29  30 1
            32   25  30 1
            33   28  31 1

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