KEGG   DRUG: Fluvastatin sodium
Entry
D00892                      Drug                                   

Name
Fluvastatin sodium (JAN/USP);
Lescol (TN)
Product
  Generic
Formula
C24H25FNO4. Na
Exact mass
433.1665
Mol weight
433.4478
Structure
Simcomp
Class
Hypolipidemic agent
 DG01660  HMG-CoA reductase inhibitor
Metabolizing enzyme substrate
 DG01642  CYP2C9 substrate
 DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate
Metabolizing enzyme inhibitor
 DG01643  CYP2C9 inhibitor
Transporter substrate
 DG02856  SLCO1B1 substrate
Transporter inhibitor
 DG02882  ABCB11 inhibitor
Remark
Therapeutic category: 2189
ATC code: C10AA04
Chemical structure group: DG00354
Product (DG00354): D00892<JP/US>
Efficacy
Antihyperlipidemic, HMG-CoA reductase inhibitor
  Disease
Hypercholesterolemia (Heterozygous familial) [DS:H00155]
Mixed dyslipidemia [DS:H01635]
Target
HMGCR [HSA:3156] [KO:K00021]
  Pathway
hsa00900  Terpenoid backbone biosynthesis
Metabolism
Enzyme: CYP2C9 [HSA:1559], CYP3A4 [HSA:1576]
Transporter: SLCO1B1 [HSA:10599]
Interaction
CYP inhibition: CYP2C9 [HSA:1559]
Transporter inhibition: ABCB11 [HSA:8647]
Structure map
map07024  HMG-CoA reductase inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C10 LIPID MODIFYING AGENTS
   C10A LIPID MODIFYING AGENTS, PLAIN
    C10AA HMG CoA reductase inhibitors
     C10AA04 Fluvastatin
      D00892  Fluvastatin sodium (JAN/USP) <JP/US>
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Dyslipidemics, HMG CoA Reductase Inhibitors
   Fluvastatin
    D00892  Fluvastatin sodium (JAN/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   218  Hyperlipidemia agents
    2189  Others
     D00892  Fluvastatin sodium (JAN/USP)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Oxidoreductases (EC1)
   Dehydrogenases
    HMGCR
     D00892  Fluvastatin sodium (JAN/USP) <JP/US>
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D00892
 Drug transporters
  D00892
Other DBs
CAS: 93957-55-2
PubChem: 7847956
ChEBI: 5137
ChEMBL: CHEMBL241778
DrugBank: DB01095
LigandBox: D00892
NIKKAJI: J556.740H
KCF data

ATOM        31
            1   Z   Na   25.8336  -11.8516 #+
            2   C8y C    12.5783  -14.7270
            3   C8x C    12.5783  -16.1297
            4   C8x C    13.7706  -16.8311
            5   C8y C    15.0330  -16.1297
            6   C8x C    15.0330  -14.7270
            7   C8x C    13.7706  -14.0257
            8   X   F    11.3861  -14.0257
            9   C8y C    16.2253  -16.8311
            10  C8y C    16.7162  -18.1636
            11  C8y C    18.0488  -18.1636
            12  N4y N    18.4696  -16.8311
            13  C8y C    17.3474  -15.9895
            14  C8x C    16.0149  -19.3559
            15  C8x C    16.7162  -20.6183
            16  C8x C    18.1189  -20.6183
            17  C8x C    18.8203  -19.3559
            18  C2b C    17.3474  -14.5868
            19  C1a C    20.9243  -16.8311
            20  C1c C    19.7320  -16.1297
            21  C1a C    19.7320  -14.7270
            22  C2b C    18.5397  -13.8854
            23  C1c C    18.5397  -12.4828
            24  C1b C    19.7320  -11.7814
            25  C1c C    20.9243  -12.4828
            26  C1b C    22.1165  -11.7814
            27  C6a C    23.3088  -12.4828
            28  O6a O    24.5011  -11.7814 #-
            29  O6a O    23.3088  -13.8854
            30  O1a O    17.3474  -11.7814
            31  O1a O    20.9243  -13.8854
BOND        32
            1     2   3 2
            2     3   4 1
            3     4   5 2
            4     5   6 1
            5     6   7 2
            6     2   7 1
            7     2   8 1
            8     5   9 1
            9     9  10 1
            10   10  11 1
            11   11  12 1
            12   12  13 1
            13    9  13 2
            14   10  14 2
            15   14  15 1
            16   15  16 2
            17   16  17 1
            18   11  17 2
            19   13  18 1
            20   19  20 1
            21   12  20 1
            22   20  21 1
            23   18  22 2
            24   22  23 1
            25   23  24 1
            26   24  25 1
            27   25  26 1
            28   26  27 1
            29   27  28 1
            30   27  29 2
            31   23  30 1 #Down
            32   25  31 1 #Up

» Japanese version   » Back

DBGET integrated database retrieval system