| Entry |
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| Name |
Polymyxin B sulfate (USP/INN);
Polymixin B sulfate (JP17);
Aerosporin (TN) |
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| Product |
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| Generic |
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| Formula |
C55H95N16O13R. xH2SO4
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| Structure |
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| Simcomp |
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| Class |
Antibacterial
DG01579 Polypeptide antibiotic
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| Remark |
| Product (DG00083): | D01066<JP/US> |
| Product (mixture): | D02144<JP> D02531<US> D11086<US> D11096<US> D11097<US> D11177<US> D11855<US> |
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| Efficacy |
Antibacterial, Cell membrane function inhibitor |
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| Comment |
Polymyxin B1 ( R = -CH3)
Polymyxin B2 ( R = -H)
Plypeptide
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| Target |
Lipopolysaccharide |
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| Interaction |
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
A ALIMENTARY TRACT AND METABOLISM
A07 ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS
A07A INTESTINAL ANTIINFECTIVES
A07AA Antibiotics
A07AA05 Polymyxin B
D01066 Polymyxin B sulfate (USP/INN) <JP/US>
J ANTIINFECTIVES FOR SYSTEMIC USE
J01 ANTIBACTERIALS FOR SYSTEMIC USE
J01X OTHER ANTIBACTERIALS
J01XB Polymyxins
J01XB02 Polymyxin B
D01066 Polymyxin B sulfate (USP/INN) <JP/US>
S SENSORY ORGANS
S01 OPHTHALMOLOGICALS
S01A ANTIINFECTIVES
S01AA Antibiotics
S01AA18 Polymyxin B
D01066 Polymyxin B sulfate (USP/INN) <JP/US>
S02 OTOLOGICALS
S02A ANTIINFECTIVES
S02AA Antiinfectives
S02AA11 Polymyxin B
D01066 Polymyxin B sulfate (USP/INN) <JP/US>
S03 OPHTHALMOLOGICAL AND OTOLOGICAL PREPARATIONS
S03A ANTIINFECTIVES
S03AA Antiinfectives
S03AA03 Polymyxin B
D01066 Polymyxin B sulfate (USP/INN) <JP/US>
USP drug classification [BR:br08302]
Antibacterials
Antibacterials, Other
Polymyxin B
D01066 Polymyxin B sulfate (USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
2 Agents affecting individual organs
26 Epidermides
263 Suppurative dermatosis agents
2634 Antibiotics for external use
D01066 Polymyxin B sulfate (USP/INN); Polymixin B sulfate (JP17)
6 Agents against pathologic organisms and parasites
61 Antibiotics
612 Acting mainly on gram-negative bacteria
6126 Polymyxin B
D01066 Polymyxin B sulfate (USP/INN); Polymixin B sulfate (JP17)
Risk category of Japanese OTC drugs [BR:br08312]
Second-class OTC drugs
Inorganic and organic chemicals
Polymyxin B
D01066 Polymyxin B sulfate (USP/INN)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D01066 Polymixin B sulfate
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| Other DBs |
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| KCF data |
ATOM 90
1 N1b N 39.6227 -19.8397
2 C1c C 38.5126 -14.2311
3 C5a C 39.6727 -13.5535
4 O5a O 39.6649 -12.2063
5 N1b N 37.3408 -13.5596
6 C1c C 45.4510 -19.2499
7 N1b N 43.1200 -19.2374
8 C1c C 41.9504 -19.9047
9 C5a C 40.7923 -19.2247
10 O5a O 40.7877 -18.1032
11 C5a C 44.2853 -19.9106
12 O5a O 44.2816 -21.2649
13 N1b N 45.4427 -17.8960
14 C5a C 46.6126 -17.2116
15 O5a O 47.7839 -17.8814
16 C1c C 46.6320 -14.4917
17 N1b N 40.8438 -14.2239
18 C1c C 42.0147 -13.5396
19 C5a C 43.1785 -14.2168
20 O5a O 43.2132 -15.5639
21 N1b N 44.3424 -13.5325
22 C1b C 47.6795 -13.7419
23 C1c C 48.8909 -14.3363
24 C1a C 50.0154 -13.5863
25 C1a C 48.8447 -15.6802
26 C1b C 42.0117 -12.1923
27 C8y C 43.1772 -11.5126
28 C8x C 44.3386 -12.1901
29 C8x C 45.5042 -11.5104
30 C8x C 45.5011 -10.1631
31 C8x C 44.3324 -9.4886
32 C8x C 43.1669 -10.1685
33 C1b C 46.6255 -19.9196
34 C1b C 46.6258 -21.2739
35 N1a N 47.7932 -21.9437
36 C1b C 41.9419 -21.2590
37 C1b C 40.7706 -21.9217
38 N1a N 40.7622 -23.2760
39 C1b C 38.5166 -15.5783
40 C1b C 39.6857 -16.2521
41 N1a N 40.8649 -15.6420
42 C1c C 38.4775 -19.1147
43 C1c C 38.5337 -17.5585
44 C5a C 37.2834 -19.7425
45 N1b N 36.2153 -19.0244
46 O5a O 37.3043 -21.0956
47 C1b C 36.2013 -17.6783
48 C1a C 39.7280 -16.9305
49 O1a O 37.3956 -16.8404
50 C1b C 35.0561 -16.9532
51 C5a C 35.7864 -13.5537
52 O5a O 35.1849 -12.3836
53 C1c C 35.1042 -14.7884
54 N1b N 33.9031 -14.0757
55 C5a C 32.7393 -14.7529
56 C1c C 31.5754 -14.0757
57 O5a O 32.7393 -16.1000
58 N1b N 30.4074 -14.7514
59 C5a C 29.2412 -14.0729
60 C1b C 31.5771 -12.7284
61 C1b C 32.7452 -12.0599
62 N1a N 32.7467 -10.7056
63 O5a O 29.2427 -12.7255
64 C1c C 28.0731 -14.7485
65 N1b N 26.8998 -14.0698
66 C1c C 28.0714 -16.4456
67 O1a O 29.2378 -17.1243
68 C1a C 26.8964 -17.1214
69 C5a C 25.7317 -14.7456
70 C1c C 24.5654 -14.0741
71 O5a O 25.7300 -16.0928
72 N1b N 23.3973 -14.7427
73 C5a C 22.2311 -14.0712
74 C1b C 21.0630 -14.7398
75 C1b C 24.5671 -12.7198
76 C1b C 25.7351 -12.0511
77 N1a N 25.7368 -10.6968
78 O5a O 22.2328 -12.7169
79 C1b C 19.8897 -14.0683
80 C1b C 18.7217 -14.7370
81 C1b C 17.5553 -14.0654
82 C1c C 16.3874 -14.7339
83 C1b C 15.2210 -14.0625
84 C1a C 16.3857 -16.0813
85 R R 14.0530 -14.7310
86 S4a S 22.0199 -20.6382
87 O1d O 20.6178 -20.6382
88 O1d O 23.4221 -20.6382
89 O1d O 22.0842 -19.2301
90 O1d O 22.0842 -22.0402
BOND 90
1 6 13 1
2 43 48 1
3 43 49 1 #Down
4 23 25 1
5 47 50 1
6 53 50 1 #Down
7 18 26 1 #Down
8 5 51 1
9 13 14 1
10 51 52 2
11 26 27 1
12 51 53 1
13 2 5 1
14 53 54 1
15 14 15 2
16 54 55 1
17 7 8 1
18 55 56 1
19 8 9 1
20 55 57 2
21 9 10 2
22 56 58 1
23 27 28 2
24 58 59 1
25 28 29 1
26 56 60 1 #Up
27 29 30 2
28 60 61 1
29 30 31 1
30 61 62 1
31 31 32 2
32 59 63 2
33 32 27 1
34 59 64 1
35 64 65 1
36 6 33 1 #Up
37 64 66 1 #Down
38 7 11 1
39 66 67 1 #Down
40 33 34 1
41 66 68 1
42 3 4 2
43 65 69 1
44 34 35 1
45 69 70 1
46 18 19 1
47 69 71 2
48 8 36 1 #Up
49 70 72 1
50 19 20 2
51 72 73 1
52 36 37 1
53 73 74 1
54 19 21 1
55 70 75 1 #Up
56 37 38 1
57 75 76 1
58 17 3 1
59 76 77 1
60 1 9 1
61 73 78 2
62 17 18 1
63 74 79 1
64 2 39 1 #Down
65 79 80 1
66 21 16 1
67 80 81 1
68 39 40 1
69 81 82 1
70 14 16 1
71 82 83 1
72 40 41 1
73 82 84 1
74 11 12 2
75 83 85 1
76 1 42 1
77 16 22 1 #Up
78 42 43 1 #Down
79 11 6 1
80 42 44 1
81 22 23 1
82 44 45 1
83 3 2 1
84 44 46 2
85 23 24 1
86 45 47 1
87 86 87 1
88 86 88 1
89 86 89 2
90 86 90 2
BRACKET 1 19.2500 -22.4700 19.2500 -18.5500
1 24.7100 -18.5500 24.7100 -22.4700
1 x
ORIGINAL 1 86 87 88 89 90
REPEAT 1
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