| Entry |
|
|---|
| Name |
Teniposide (USP/INN);
Vumon (TN) |
|---|
| Formula |
C32H32O13S
|
|---|
| Exact mass |
656.1564
|
|---|
| Mol weight |
656.65
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Antineoplastic
DG01529 Topoisomerase inhibitor
DG01527 Topoisomerase II inhibitor
|
|---|
| Remark |
|
|---|
| Efficacy |
Antineoplastic, Topoisomerase II inhibitor |
|---|
| Disease |
|
|---|
| Comment |
Podophyllotoxin [DR: D05529] derivative
|
|---|
| Target |
|
|---|
| Interaction |
|
|---|
| Structure map |
| map07042 | Antineoplastics - agents from natural products |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
L01 ANTINEOPLASTIC AGENTS
L01C PLANT ALKALOIDS AND OTHER NATURAL PRODUCTS
L01CB Podophyllotoxin derivatives
L01CB02 Teniposide
D02698 Teniposide (USP/INN)
USP drug classification [BR:br08302]
Antineoplastics
Molecular Target Inhibitors
Topoisomerase Inhibitors
Teniposide
D02698 Teniposide (USP/INN)
Drug groups [BR:br08330]
Antineoplastic
DG01529 Topoisomerase inhibitor
DG01527 Topoisomerase II inhibitor
D02698 Teniposide
Target-based classification of drugs [BR:br08310]
Enzymes
Isomerases (EC5)
DNA topoisomerase
TOP2
D02698 Teniposide (USP/INN)
|
|---|
| Other DBs |
|
|---|
| KCF data |
ATOM 46
1 O2a O 27.5800 -17.1500
2 C8x C 25.1300 -21.3500
3 C8x C 25.1300 -18.5500
4 C8y C 23.9400 -20.6500
5 C8y C 23.9400 -19.2500
6 O2x O 22.6100 -18.8300
7 C1x C 21.7700 -19.9500
8 O2x O 22.6100 -21.0700
9 C8y C 26.3200 -19.2500
10 C8y C 26.3200 -20.6500
11 C1y C 27.5100 -21.3500
12 C1y C 27.5800 -18.5500
13 C1y C 28.7700 -19.2500
14 C1y C 28.7700 -20.6500
15 O7x O 30.9400 -19.9500
16 O6a O 30.5200 -22.4700
17 C1x C 30.1000 -18.8300
18 C7x C 30.1000 -21.1400
19 C8y C 27.5100 -22.7500
20 C8x C 26.3200 -23.4500
21 C8y C 26.3200 -24.7800
22 C8y C 27.5100 -25.5500
23 C8y C 28.7000 -24.8500
24 C8x C 28.7700 -23.4500
25 O2a O 29.9600 -25.5500
26 O2a O 25.1300 -25.4800
27 C1a C 31.1500 -24.8500
28 C1a C 23.9400 -24.7800
29 O1a O 27.5100 -26.8800
30 C1y C 25.0600 -14.2800
31 C1y C 26.2500 -14.9100
32 C1y C 26.2500 -16.3100
33 O2x O 25.0600 -17.0100
34 O1a O 25.0600 -12.8800
35 O1a O 27.4400 -14.2100
36 C1y C 23.8000 -14.9800
37 C1y C 23.8000 -16.3800
38 C1x C 22.6100 -17.0800
39 O2x O 21.4200 -16.3800
40 C1y C 21.4200 -14.9800
41 O2x O 22.6100 -14.2800
42 C8y C 20.2300 -14.2800
43 S2x S 18.9700 -14.9100
44 C8x C 17.9900 -13.8600
45 C8x C 18.6900 -12.6700
46 C8x C 20.0900 -12.9500
BOND 53
1 15 17 1
2 18 16 2
3 12 1 1 #Up
4 13 17 1
5 14 18 1
6 11 19 1 #Down
7 4 2 2
8 2 10 1
9 9 3 1
10 3 5 2
11 19 20 2
12 20 21 1
13 21 22 2
14 22 23 1
15 23 24 2
16 24 19 1
17 23 25 1
18 21 26 1
19 25 27 1
20 26 28 1
21 4 5 1
22 22 29 1
23 5 6 1
24 6 7 1
25 7 8 1
26 8 4 1
27 9 10 2
28 10 11 1
29 11 14 1
30 13 12 1
31 12 9 1
32 13 14 1
33 18 15 1
34 31 35 1 #Up
35 40 42 1
36 30 31 1
37 31 32 1
38 32 33 1
39 33 37 1
40 30 34 1 #Down
41 36 30 1
42 36 37 1
43 37 38 1
44 38 39 1
45 39 40 1
46 43 44 1
47 40 41 1
48 41 36 1
49 42 43 1
50 44 45 2
51 45 46 1
52 46 42 2
53 1 32 1 #Down
|
|---|
