KEGG   DRUG: Ropivacaine hydrochlorideHelp
Entry
D04048                      Drug                                   

Name
Ropivacaine hydrochloride (USP);
Ropivacaine hydrochloride hydrate (JAN);
Anapeine (TN)
Product
  Generic
Formula
C17H26N2O. HCl. H2O
Exact mass
328.1918
Mol weight
328.8774
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Neuropsychiatric agent
 DG02030  Anesthetics
  DG01675  Local anesthetic
   DG01673  Amide type local anesthetic
 DG01675  Local anesthetic
  DG01673  Amide type local anesthetic
Metabolizing enzyme substrate
 DG01892  CYP1A2 substrate
 DG02913  CYP3A4 substrate
Remark
Therapeutic category: 1214
ATC code: N01BB09
Chemical structure group: DG00806
Product (DG00806): D04048<JP/US>
Efficacy
Anesthetic (local)
Target
SCN1A [HSA:6323] [KO:K04833]
SCN2A [HSA:6326] [KO:K04834]
SCN3A [HSA:6328] [KO:K04836]
SCN4A [HSA:6329] [KO:K04837]
SCN5A [HSA:6331] [KO:K04838]
SCN8A [HSA:6334] [KO:K04840]
SCN9A [HSA:6335] [KO:K04841]
SCN10A [HSA:6336] [KO:K04842]
SCN11A [HSA:11280] [KO:K04843]
  Pathway
hsa04728  Dopaminergic synapse
Metabolism
Enzyme: CYP1A2 [HSA:1544], CYP3A4 [HSA:1576]
Interaction
Drug interaction
Structure map
map07231  Sodium channel blocking drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N01 ANESTHETICS
   N01B ANESTHETICS, LOCAL
    N01BB Amides
     N01BB09 Ropivacaine
      D04048  Ropivacaine hydrochloride (USP) <JP/US>
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  12  Agents affecting peripheral nervous system
   121  Local anesthetics
    1214  Xylidines
     D04048  Ropivacaine hydrochloride (USP); Ropivacaine hydrochloride hydrate (JAN)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated ion channels
   Sodium channels
    SCN1A
     D04048  Ropivacaine hydrochloride (USP) <JP/US>
    SCN2A
     D04048  Ropivacaine hydrochloride (USP) <JP/US>
    SCN3A
     D04048  Ropivacaine hydrochloride (USP) <JP/US>
    SCN4A
     D04048  Ropivacaine hydrochloride (USP) <JP/US>
    SCN5A
     D04048  Ropivacaine hydrochloride (USP) <JP/US>
    SCN8A
     D04048  Ropivacaine hydrochloride (USP) <JP/US>
    SCN9A
     D04048  Ropivacaine hydrochloride (USP) <JP/US>
    SCN10A
     D04048  Ropivacaine hydrochloride (USP) <JP/US>
    SCN11A
     D04048  Ropivacaine hydrochloride (USP) <JP/US>
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D04048
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D04048
BRITE hierarchy
Other DBs
CAS: 132112-35-7
PubChem: 47206010
ChEBI: 34954
DrugBank: DB00296
LigandBox: D04048
NIKKAJI: J2.220.367C
KCF data Show

ATOM        22
            1   X   Cl   31.2200  -18.2001
            2   O0  O    31.7800  -21.0001
            3   C8x C    20.8600  -18.3400
            4   C8x C    20.8600  -19.7400
            5   C8y C    22.0500  -20.4400
            6   C8y C    23.3100  -19.7400
            7   C8y C    23.3100  -18.3400
            8   C8x C    22.0500  -17.6400
            9   N1b N    24.5000  -20.4400
            10  C5a C    25.6900  -19.7400
            11  C1a C    24.5000  -17.6400
            12  C1y C    26.9500  -20.4400
            13  N1y N    26.9500  -21.8400
            14  C1x C    28.1400  -22.5400
            15  C1x C    29.3300  -21.8400
            16  C1x C    29.3300  -20.4400
            17  C1x C    28.1400  -19.7400
            18  C1a C    22.0500  -21.8400
            19  C1b C    25.6900  -22.5400
            20  C1b C    24.5000  -21.8400
            21  C1a C    23.3100  -22.5400
            22  O5a O    25.6900  -18.3400
BOND        21
            1     3   4 2
            2     4   5 1
            3     5   6 2
            4     6   7 1
            5     7   8 2
            6     3   8 1
            7     6   9 1
            8     9  10 1
            9     7  11 1
            10   12  10 1 #Down
            11   12  13 1
            12   13  14 1
            13   14  15 1
            14   15  16 1
            15   16  17 1
            16   12  17 1
            17    5  18 1
            18   13  19 1
            19   19  20 1
            20   20  21 1
            21   10  22 2

» Japanese version   » Back

DBGET integrated database retrieval system