KEGG   DRUG: Metformin
Entry
D04966                      Drug                                   

Name
Metformin (USAN/INN)
Formula
C4H11N5
Exact mass
129.1014
Mol weight
129.1636
Structure
Simcomp
Class
Antidiabetic agent
 DG01685  Insulin sensitizer
  DG01684  Biguanide antidiabetic
 DG02044  Hypoglycemics
  DG01684  Biguanide antidiabetic
Remark
Same as: C07151
ATC code: A10BA02
Chemical structure group: DG00113
Product (DG00113): D00944<JP/US>
Product (mixture): D09744<JP/US> D10586<US> D10587<US> D10752<US> D11067<US>
Efficacy
Antidiabetic, Hypoglycemic, AMP kinase activator
Comment
Biguanide
Target
AMPK (PRKAA) [HSA:5562 5563] [KO:K07198]
  Pathway
hsa04152  AMPK signaling pathway
hsa04910  Insulin signaling pathway
hsa04920  Adipocytokine signaling pathway
Interaction
Structure map
map07051  Antidiabetics
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A10 DRUGS USED IN DIABETES
   A10B BLOOD GLUCOSE LOWERING DRUGS, EXCL. INSULINS
    A10BA Biguanides
     A10BA02 Metformin
      D04966  Metformin (USAN/INN)
Target-based classification of drugs [BR:br08310]
 Protein kinases
  Serine/threonine kinases
   CAMK group
    AMPK (PRKAA)
     D04966  Metformin (USAN/INN)
Other DBs
CAS: 657-24-9
PubChem: 47206702
ChEBI: 6801
ChEMBL: CHEMBL1431
DrugBank: DB00331
PDB-CCD: MF8[PDBj]
LigandBox: D04966
NIKKAJI: J9.463C
KCF data

ATOM        9
            1   C2c C    26.2960  -19.4016
            2   N1b N    25.0898  -18.7081
            3   N1c N    27.5139  -18.7081
            4   N2a N    26.2960  -20.8058
            5   C2c C    23.8721  -19.4016
            6   C1a C    28.7260  -19.4016
            7   C1a C    27.5139  -17.3038
            8   N1a N    22.6600  -18.7081
            9   N2a N    23.8721  -20.8058
BOND        8
            1     1   2 1
            2     1   3 1
            3     1   4 2
            4     2   5 1
            5     3   6 1
            6     3   7 1
            7     5   8 1
            8     5   9 2

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