KEGG   DRUG: TenecteplaseHelp
Entry
D06070                      Drug                                   

Name
Tenecteplase (USAN/INN);
Tnkase (TN)
Product
Formula
C2558H3872N738O781S40
Exact mass
58703.4783
Mol weight
58741.1903
Sequence
SYQVICRDEK TQMIYQQHQS WLRPVLRSNR VEYCWCNSGR AQCHSVPVKS CSEPRCFNGG
TCQQALYFSD FVCQCPEGFA GKCCEIDTRA TCYEDQGISY RGNWSTAESG AECTNWQSSA
LAQKPYSGRR PDAIRLGLGN HNYCRNPDRD SKPWCYVFKA GKYSSEFCST PACSEGNSDC
YFGNGSAYRG THSLTESGAS CLPWNSMILI GKVYTAQNPS AQALGLGKHN YCRNPDGDAK
PWCHVLKNRR LTWEYCDVPS CSTCGLRQYS QPQFRIKGGL FADIASHPWQ AAIFAAAAAS
PGERFLCGGI LISSCWILSA AHCFQERFPP HHLTVILGRT YRVVPGEEEQ KFEVEKYIVH
KEFDDDTYDN DIALLQLKSD SSRCAQESSV VRTVCLPPAD LQLPDWTECE LSGYGKHEAL
SPFYSERLKE AHVRLYPSSR CTSQHLLNRT VTDNMLCAGD TRSGGPQANL HDACQGDSGG
PLVCLNDGRM TLVGIISWGL GCGQKDVPGV YTKVTNYLDW IRDNMRP
(Disulfide bridge: 6-36, 34-43, 51-62,56-73, 75-84, 92-173, 113-155, 144-168, 180-261, 201-243, 232-256, 264-395, 307-323, 315-384, 409-484, 441-457, 474-502)
  Type
Peptide
Class
Cardiovascular agent
 DG01950  Antithrombotic agent
  DG01707  Fibrinolytic
   DG01664  Tissue plasminogen activator (t-PA)
 DG01707  Fibrinolytic
  DG01664  Tissue plasminogen activator (t-PA)
Remark
ATC code: B01AD11
Product: D06070<US>
Efficacy
Thrombolytic, Tissue plasminogen activator (t-PA)
Comment
tissue plasminogen activator (t-PA) [HSA:5327] [KO:K01343] [EC:3.4.21.68]
Treatment of acute thrombotic disorders
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 B BLOOD AND BLOOD FORMING ORGANS
  B01 ANTITHROMBOTIC AGENTS
   B01A ANTITHROMBOTIC AGENTS
    B01AD Enzymes
     B01AD11 Tenecteplase
      D06070  Tenecteplase (USAN/INN) <US>
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D06070
BRITE hierarchy
Other DBs
CAS: 191588-94-0
PubChem: 47207728
DrugBank: DB00031

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