KEGG   DRUG: FluvastatinHelp
Entry
D07983                      Drug                                   

Name
Fluvastatin (INN);
Fluvas (TN)
Formula
C24H26FNO4
Exact mass
411.1846
Mol weight
411.4659
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Cardiovascular agent
 DG01660  HMG-CoA reductase inhibitor
 DG01946  Hypolipidemic agent
  DG01660  HMG-CoA reductase inhibitor
Metabolizing enzyme substrate
 DG01642  CYP2C9 substrate
 DG02913  CYP3A4 substrate
Metabolizing enzyme inhibitor
 DG01643  CYP2C9 inhibitor
Transporter substrate
 DG02856  SLCO1B1 (OATP1B1) substrate
Transporter inhibitor
 DG02882  ABCB11 inhibitor
Remark
Same as: C07014
ATC code: C10AA04
Chemical structure group: DG00354
Product (DG00354): D00892<JP/US>
Efficacy
Antihyperlipidemic, HMG-CoA reductase inhibitor
Target
HMGCR [HSA:3156] [KO:K00021]
  Pathway
hsa00900  Terpenoid backbone biosynthesis
Metabolism
Enzyme: CYP2C9 [HSA:1559], CYP3A4 [HSA:1576]
Transporter: SLCO1B1 [HSA:10599]
Interaction
CYP inhibition: CYP2C9 [HSA:1559]
Transporter inhibition: ABCB11 [HSA:8647]
Drug interaction
Structure map
map07024  HMG-CoA reductase inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C10 LIPID MODIFYING AGENTS
   C10A LIPID MODIFYING AGENTS, PLAIN
    C10AA HMG CoA reductase inhibitors
     C10AA04 Fluvastatin
      D07983  Fluvastatin (INN)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Oxidoreductases (EC1)
   Dehydrogenases
    HMGCR
     D07983  Fluvastatin (INN)
BRITE hierarchy
Other DBs
CAS: 93957-54-1
PubChem: 96024677
ChEBI: 38561 5136
ChEMBL: CHEMBL350239
DrugBank: DB01095
LigandBox: D07983
NIKKAJI: J360.319I
KCF data Show

ATOM        30
            1   C8y C    20.9855  -16.8573
            2   C8x C    20.9855  -18.2563
            3   C8x C    22.1746  -18.9557
            4   C8y C    23.4336  -18.2563
            5   C8x C    23.4336  -16.8573
            6   C8x C    22.1746  -16.1579
            7   X   F    19.7964  -16.1579
            8   C8y C    24.6227  -18.9557
            9   C8y C    25.1123  -20.2847
            10  C8y C    26.4413  -20.2847
            11  N4y N    26.8610  -18.9557
            12  C8y C    25.7418  -18.1164
            13  C8x C    24.4129  -21.5437
            14  C8x C    25.1123  -22.8028
            15  C8x C    26.5113  -22.8028
            16  C8x C    27.2107  -21.5437
            17  C2b C    25.7418  -16.7174
            18  C1a C    29.3091  -18.9557
            19  C1c C    28.1200  -18.2563
            20  C1a C    28.1200  -16.8573
            21  C2b C    26.9309  -16.0180
            22  C1c C    26.9309  -14.6191
            23  C1b C    28.1200  -13.9196
            24  C1c C    29.3091  -14.6191
            25  C1b C    30.4982  -13.9196
            26  C6a C    31.6873  -14.6191
            27  O6a O    32.8764  -13.9196
            28  O6a O    31.6873  -16.0180
            29  O1a O    25.7418  -13.9196
            30  O1a O    29.3091  -16.0180
BOND        32
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     1   7 1
            8     4   8 1
            9     8   9 1
            10    9  10 1
            11   10  11 1
            12   11  12 1
            13    8  12 2
            14    9  13 2
            15   13  14 1
            16   14  15 2
            17   15  16 1
            18   10  16 2
            19   12  17 1
            20   18  19 1
            21   11  19 1
            22   19  20 1
            23   17  21 2
            24   21  22 1
            25   22  23 1
            26   23  24 1
            27   24  25 1
            28   25  26 1
            29   26  27 1
            30   26  28 2
            31   22  29 1 #Down
            32   24  30 1 #Up

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