KEGG   DRUG: Remifentanil
Entry
D08473                      Drug                                   

Name
Remifentanil (INN);
Ultiva (TN)
Formula
C20H28N2O5
Exact mass
376.1998
Mol weight
376.4467
Structure
Simcomp
Class
Neuropsychiatric agent
 DG02030  Anesthetics
  DG02027  General anesthetics
   DG02026  Opioid anesthetics
 DG01564  Opioid receptor agonist
  DG01563  mu-Opioid receptor agonist
Analgesics
 DG01984  Opioid analgesics
Remark
Same as: C08021
ATC code: N01AH06
Chemical structure group: DG00795
Product (DG00795): D01177<JP/US>
Efficacy
Analgesic (narcotic), Opioid receptor agonist
Comment
Phenylpiperidine derivative
Target
OPRM1 [HSA:4988] [KO:K04215]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Interaction
Structure map
map07224  Opioid receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N01 ANESTHETICS
   N01A ANESTHETICS, GENERAL
    N01AH Opioid anesthetics
     N01AH06 Remifentanil
      D08473  Remifentanil (INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Opioid
    OPRM1
     D08473  Remifentanil (INN)
Other DBs
CAS: 132875-61-7
PubChem: 96025159
ChEBI: 8802
ChEMBL: CHEMBL1005
DrugBank: DB00899
LigandBox: D08473
NIKKAJI: J423.836B
KCF data

ATOM        27
            1   C8x C    16.4500  -27.3700
            2   C8x C    16.4500  -28.7700
            3   C8x C    17.6400  -29.4700
            4   C8x C    18.9000  -28.7700
            5   C8y C    18.9000  -27.3700
            6   C8x C    17.6400  -26.6700
            7   N1c N    20.0900  -26.6700
            8   C1z C    21.3500  -27.3700
            9   C1x C    21.3500  -28.7700
            10  C1x C    22.5400  -29.4700
            11  N1y N    23.7300  -28.7700
            12  C1x C    23.7300  -27.3700
            13  C1x C    22.5400  -26.6700
            14  C1b C    24.9900  -29.4700
            15  C1b C    26.1800  -28.7700
            16  C7a C    27.3700  -29.4700
            17  C5a C    20.0900  -25.2700
            18  O5a O    18.9000  -24.5700
            19  C1b C    21.3500  -24.5700
            20  C1a C    22.5400  -25.2700
            21  C7a C    20.7200  -28.1400
            22  O7a O    28.5881  -28.7799
            23  C1a C    29.7695  -29.4750
            24  O6a O    27.3586  -30.8700
            25  O7a O    20.7200  -29.5400
            26  O6a O    19.5666  -27.8142
            27  C1a C    19.5076  -30.2400
BOND        28
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     5   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11   10  11 1
            12   11  12 1
            13   12  13 1
            14    8  13 1
            15   11  14 1
            16   14  15 1
            17   15  16 1
            18    7  17 1
            19   17  18 2
            20   17  19 1
            21   19  20 1
            22    8  21 1
            23   16  22 1
            24   22  23 1
            25   16  24 2
            26   21  25 1
            27   21  26 2
            28   25  27 1

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