KEGG   DRUG: Panobinostat lactateHelp
Entry
D10019                      Drug                                   

Name
Panobinostat lactate (JAN);
Farydak (TN)
Product
Formula
C21H23N3O2. C3H6O3
Exact mass
439.2107
Mol weight
439.5042
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Metabolizing enzyme substrate
 DG02913  CYP3A4 substrate
Metabolizing enzyme inhibitor
 DG01645  CYP2D6 inhibitor
Remark
Therapeutic category: 4291
ATC code: L01XX42
Chemical structure group: DG01403
Product (DG01403): D10019<JP/US>
Efficacy
Antineoplastic, Histone deacetylase inhibitor
  Disease
Multiple myeloma [DS:H00010]
Target
  Pathway
hsa04110  Cell cycle
hsa04330  Notch signaling pathway
hsa05200  Pathways in cancer
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Interaction
CYP inhibition: CYP2D6 [HSA:1565]
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L01 ANTINEOPLASTIC AGENTS
   L01X OTHER ANTINEOPLASTIC AGENTS
    L01XX Other antineoplastic agents
     L01XX42 Panobinostat
      D10019  Panobinostat lactate (JAN) <JP/US>
USP drug classification [BR:br08302]
 Antineoplastics
  Molecular Target Inhibitors
   Panobinostat
    D10019  Panobinostat lactate (JAN)
Therapeutic category of drugs in Japan [BR:br08301]
 4  Agents affecting cellular function
  42  Antineoplastics
   429  Miscellaneous
    4291  Other Antitumors
     D10019  Panobinostat lactate (JAN)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Hydrolases (EC3)
   Histone deacetylase
    HDAC
     D10019  Panobinostat lactate (JAN) <JP/US>
Antineoplastics [br08340.html]
 D10019
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D10019
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D10019
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D10019
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D10019
BRITE hierarchy
Other DBs
PubChem: 135626740
ChEBI: 85991
ChEMBL: CHEMBL3545368
LigandBox: D10019
KCF data Show

ATOM        32
            1   C8y C    16.6600  -18.5500
            2   C8x C    16.6600  -17.1500
            3   C8x C    17.8500  -16.4500
            4   C8y C    19.1100  -17.1500
            5   C8x C    19.1100  -18.5500
            6   C8x C    17.8500  -19.2500
            7   C2b C    20.3000  -16.4500
            8   C2b C    21.4900  -17.1500
            9   C5a C    22.6800  -16.4500
            10  N1b N    23.8700  -17.1500
            11  O5a O    22.6800  -15.0500
            12  O1b O    25.0600  -16.4500
            13  C1b C    15.4700  -19.2500
            14  N1b N    14.2800  -18.5500
            15  C1b C    13.0900  -19.2500
            16  C1b C    11.9000  -18.5500
            17  C8y C    10.7100  -19.2500
            18  C8y C    10.7100  -20.6500
            19  N4x N     9.3800  -21.0700
            20  C8y C     8.5400  -19.9500
            21  C8y C     9.3800  -18.8300
            22  C8x C     7.1400  -19.8100
            23  C8x C     6.5800  -18.4800
            24  C8x C     7.4200  -17.3600
            25  C8x C     8.8200  -17.5000
            26  C1a C    11.8300  -21.4900
            27  O1a O    26.4600  -19.3900
            28  C1c C    27.6724  -20.0900
            29  C6a C    28.8679  -19.3996
            30  C1a C    27.6725  -21.4898
            31  O6a O    30.0553  -20.0851
            32  O6a O    28.8680  -17.9903
BOND        33
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     4   7 1
            8     7   8 2
            9     8   9 1
            10    9  10 1
            11    9  11 2
            12   10  12 1
            13    1  13 1
            14   13  14 1
            15   14  15 1
            16   15  16 1
            17   16  17 1
            18   17  18 2
            19   18  19 1
            20   19  20 1
            21   20  21 1
            22   17  21 1
            23   20  22 2
            24   22  23 1
            25   23  24 2
            26   24  25 1
            27   21  25 2
            28   18  26 1
            29   27  28 1
            30   28  29 1
            31   28  30 1
            32   29  31 1
            33   29  32 2

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