KEGG   DISEASE: Burkitt lymphoma
Entry
H00008                      Disease                                
Name
Burkitt lymphoma
  Supergrp
Non-Hodgkin lymphoma [DS:H02418]
Primary central nervous system lymphoma [DS:H02424]
Description
Burkitt lymphoma (BL) is a highly aggressive mature B-cell non-Hodgkin's lymphoma consisting of endemic, sporadic, and immunodeficiency-associated variants. Endemic BL (eBL) affects children and young adults in Africa and some other geographical areas and carries Epstein-Barr virus (EBV) in more than 95% of cases. In contrast, sporadic BL (sBL) among adolescents in Europe and North America are mostly EBV-negative. A third type of BL is associated with HIV-infection in adults. All of these subtypes possess chromosomal rearrangements of the c-myc oncogene, the genetic hallmark of BL that contributes to lymphomagenesis through alterations in cell cycle regulation, cellular differentiation, apoptosis, cellular adhesion, and metabolism. Many BL carry point mutation in the p53 tumor suppressor gene or other defects in the p14ARF-MDM2-p53 pathway, and inactivation of the p16INK4a gene by promoter methylation or homozygous deletion. This indicates that disruption of both the pRb and p53 tumor suppressor pathways is critical for BL development.
Category
Cancer
Brite
Human diseases in ICD-11 classification [BR:br08403]
 02 Neoplasms
  Neoplasms of haematopoietic or lymphoid tissues
   Mature B-cell neoplasms
    2A85  Other specified mature B-cell neoplasms or lymphoma
     H00008  Burkitt lymphoma
Pathway-based classification of diseases [BR:br08402]
 Signal transduction
  nt06530  PI3K signaling
   H00008  Burkitt lymphoma
  nt06518  JAK-STAT signaling
   H00008  Burkitt lymphoma
  nt06516  TNF signaling
   H00008  Burkitt lymphoma
  nt06528  Calcium signaling
   H00008  Burkitt lymphoma
 Cellular process
  nt06524  Apoptosis
   H00008  Burkitt lymphoma
 Immune system
  nt06517  TLR signaling
   H00008  Burkitt lymphoma
  nt06519  RLR signaling
   H00008  Burkitt lymphoma
  nt06537  TCR/BCR signaling
   H00008  Burkitt lymphoma
Tumor markers [br08442.html]
 H00008
Pathway
hsa05169  Epstein-Barr virus infection
Network
nt06165 Epstein-Barr virus (EBV)
nt06516 TNF signaling
nt06517 TLR signaling
nt06518 JAK-STAT signaling
nt06519 RLR signaling
nt06524 Apoptosis
nt06528 Calcium signaling
nt06530 PI3K signaling
nt06537 TCR/BCR signaling
Gene
MYC-IgH (translocation) [HSA:4609] [KO:K04377]
p53 (mutation) [HSA:7157] [KO:K04451]
p16/INK4A (promoter methylation) [HSA:1029] [KO:K06621]
Pathogen
Human herpesvirus 4 (Epstein-Barr virus) [GN:T40079]
Human immunodeficiency virus 1 (HIV-1) [GN:T40001]
Drug
Cyclophosphamide [DR:D00287]
Pemigatinib [DR:D11417] (FGFR1 rearrangement)
Epcoritamab [DR:D12368]
Other DBs
ICD-11: 2A85.6
ICD-10: C83.7
MeSH: D002051
Reference
PMID:12191637
  Authors
Lindstrom MS, Wiman KG.
  Title
Role of genetic and epigenetic changes in Burkitt lymphoma.
  Journal
Semin Cancer Biol 12:381-7 (2002)
DOI:10.1016/S1044-579X(02)00058-5
Reference
PMID:15803153
  Authors
Kuppers R.
  Title
Mechanisms of B-cell lymphoma pathogenesis.
  Journal
Nat Rev Cancer 5:251-62 (2005)
DOI:10.1038/nrc1589
Reference
PMID:16062089
  Authors
Patel P, Moazzam N, Potti A, Mehdi SA.
  Title
Azathioprine induced hodgkin lymphoma: a case report and review of literature.
  Journal
Am J Clin Oncol 28:427-8 (2005)
DOI:10.1097/01.coc.0000168670.28659.8d
Reference
PMID:15760280
  Authors
Schottenfeld D, Beebe-Dimmer JL.
  Title
Advances in cancer epidemiology: understanding causal mechanisms and the evidence for implementing interventions.
  Journal
Annu Rev Public Health 26:37-60 (2005)
DOI:10.1146/annurev.publhealth.26.021304.144402
Reference
PMID:15660110
  Authors
Luch A.
  Title
Nature and nurture - lessons from chemical carcinogenesis.
  Journal
Nat Rev Cancer 5:113-25 (2005)
DOI:10.1038/nrc1546
Reference
PMID:12464351
  Authors
Kolman A, Chovanec M, Osterman-Golkar S.
  Title
Genotoxic effects of ethylene oxide, propylene oxide and epichlorohydrin in humans: update review (1990-2001).
  Journal
Mutat Res 512:173-94 (2002)
DOI:10.1016/S1383-5742(02)00067-4
Reference
PMID:17530489
  Authors
Abnet CC.
  Title
Carcinogenic food contaminants.
  Journal
Cancer Invest 25:189-96 (2007)
DOI:10.1080/07357900701208733

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