KEGG   DISEASE: Cervical cancerHelp
Entry
H00030                      Disease                                

Name
Cervical cancer
Description
Cervical cancer is the second largest cause of cancer-related death in women worldwide, and it occurs following persistent infection, sometimes for decades, with a specific subset of human papillomavirus (HPV) types, particularly types 16, 18, 33 and 42. Experimental studies show that the E6 and E7 genes of these high risk HPVs are oncogenes that deregulate key cell cycle controls. The E6 and E7 oncoproteins bind respectively to the p53 and Retinoblastoma (Rb) tumor suppressor proteins, which are involved in the regulation of growth control. The abnormalities in other cellular genes found in cervical cancer, including mutations in ras family of genes, and amplification in EGFR and ERBB2, may also play an important role in carcinogenesis and the aggressiveness of cervical tumors, although to date the role of most of these genetic abnormalities does not appear to be as important as the role of HPV.
Category
Cancer
Brite
Human diseases [BR:br08402]
 Cancers
  Cancers of the breast and female genital organs
   H00030  Cervical cancer
Human diseases in ICD-10 classification [BR:br08403]
 2. Neoplasms (C00-D48)
  C51-C58  Malignant neoplasms of female genital organs
   C53  Malignant neoplasm of cervix uteri
    H00030  Cervical cancer
Cancer-accociated carbohydrates [br08441.html]
 H00030
BRITE hierarchy
Pathway
hsa05165  Human papillomavirus infection
hsa05203  Viral carcinogenesis
Network
N00190  HPV E5 to host-cell-protein activation
N00191  HPV E5 to host-cell-protein inhibition
N00192  HPV E6 to host-cell-protein activation
N00193  HPV E6 to host-cell-protein inhibition
N00194  HPV E7 to host-cell-protein activation
N00195  HPV E7 to host-cell-protein inhibition
N00341  HPV E6 to the Scribble/Dlg/Lgl polarity module
N00343  HPV E6 to MAGI-PTEN signaling pathway
N00345  HPV E6 to CRB3-Pals1-PATJ complex
N00346  HPV E6 to TLR-IRF3 signaling pathway
N00348  HPV E6 to p300-p21-Cell cycle G1/S
N00349  HPV E6 to p300-p21-Cell cycle G1/S
N00350  HPV E6 to extrinsic apoptotic pathway
N00351  HPV E6 to extrinsic apoptotic pathway
N00352  HPV E6 to extrinsic apoptotic pathway
N00353  HPV E6 to PTEN-PIP3-AKT signaling pathway
N00354  HPV E6 to PTEN-PIP3-AKT signaling pathway
N00356  HPV E7 to PP2A-AKT signaling patyway
N00357  HPV E6 to PI3K signaling pathway
N00358  HPV E6 to p21-cell cycle G1/S
N00359  HPV E7 to p27-cell cycle G1/S
N00360  HPV E7 to p27-cell cycle G1/S
N00361  HPV E7 to cell cycle G1/S
N00362  HPV E5 to p21-cell cycle G1/S
N00364  HPV E5 to Antigen processing and presentation by MHC class I molecules
N00365  HPV E7 to cell cycle G1/S
N00366  HPV E5 to EGFR-PI3K signaling pathway
N00367  HPV E5 to EGFR-RAS-ERK signaling pathway
N00368  HPV E5 to PDGFR-PI3K signaling pathway
N00369  HPV E5 to PDGFR-RAS-ERK signaling pathway
N00371  HPV E7 to pyruvate generation
N00372  HPV E7 to p300-p21-Cell cycle G1/S
N00373  HPV E6 to NFX1-mediated transcription
N00375  HPV E7 to TNF-IRF1 signaling pathway
N00376  HPV E7 to TBP1-mediated transcription
N00377  HPV E6 to IFN signaling pathway
N00378  HPV E6 to IFN signaling pathway
N00379  HPV E7 to IFN signaling pathway
N00380  HPV E6 to Notch signaling pathway
N00381  HPV E6 to Notch signaling pathway
N00382  HPV E6 to Notch signaling pathway
N00383  HPV E6 to intrinsic apoptotic pathway
N00384  HPV E6 to intrinsic apoptotic pathway
Gene
K-ras (mutation) [HSA:3845] [KO:K07827]
H-ras (mutation) [HSA:3265] [KO:K02833]
EGFR (amplification) [HSA:1956] [KO:K04361]
ERBB2 (amplification) [HSA:2064] [KO:K05083]
p21 (overexpression) [HSA:1026] [KO:K06625]
CDK4 (overexpression) [HSA:1019] [KO:K02089]
Bcl-2 (overexpression) [HSA:596] [KO:K02161]
Carcinogen
Azathioprine [DG:DG00743]
Diethylstilboestrol [CPD:C07620] [DR:D00577]
Estrogens, nonsteroidal
Tobacco smoking and tobacco smoke
Pathogen
Human papillomavirus type 16 [GN:T40087]
Human papillomavirus type 18 [GN:T40088]
Human papillomavirus type 45
Drug
Recombinant adsorbed quadrivalent human papillomavirus virus-like particle vaccine [DR:D10192]
Bevacizumab [DR:D06409]
Topotecan hydrochloride [DR:D02168]
Comment
ICD-O: 8070/3, Tumor type: Squamous cell carcinoma, not otherwise specified
ICD-O: 8140/3, Tumor type: Adenocarcinoma
Other DBs
ICD-10: C53
MeSH: D002583
Reference
PMID:11486705 (gene, carcinogen)
  Authors
Wolf JK, Ramirez PT.
  Title
The molecular biology of cervical cancer.
  Journal
Cancer Invest 19:621-9 (2001)
DOI:10.1081/CNV-100104290
Reference
PMID:10471054 (gene, carcinogen)
  Authors
Lazo PA.
  Title
The molecular genetics of cervical carcinoma.
  Journal
Br J Cancer 80:2008-18 (1999)
DOI:10.1038/sj.bjc.6690635
Reference
PMID:16062089 (carcinogen)
  Authors
Patel P, Moazzam N, Potti A, Mehdi SA.
  Title
Azathioprine induced hodgkin lymphoma: a case report and review of literature.
  Journal
Am J Clin Oncol 28:427-8 (2005)
Reference
PMID:15168959 (carcinogen)
  Authors
Schrager S, Potter BE.
  Title
Diethylstilbestrol exposure.
  Journal
Am Fam Physician 69:2395-400 (2004)
Reference
PMID:17390375 (carcinogen)
  Authors
Troisi R, Hatch EE, Titus-Ernstoff L, Hyer M, Palmer JR, Robboy SJ, Strohsnitter WC, Kaufman R, Herbst AL, Hoover RN.
  Title
Cancer risk in women prenatally exposed to diethylstilbestrol.
  Journal
Int J Cancer 121:356-60 (2007)
DOI:10.1002/ijc.22631
Reference
PMID:11281434 (carcinogen)
  Authors
Severson J, Evans TY, Lee P, Chan T, Arany I, Tyring SK.
  Title
Human papillomavirus infections: epidemiology, pathogenesis, and therapy.
  Journal
J Cutan Med Surg 5:43-60 (2001)
DOI:10.1177/120347540100500110
Reference
PMID:15489140 (carcinogen)
  Authors
Wogan GN, Hecht SS, Felton JS, Conney AH, Loeb LA.
  Title
Environmental and chemical carcinogenesis.
  Journal
Semin Cancer Biol 14:473-86 (2004)
DOI:10.1016/j.semcancer.2004.06.010
Reference
PMID:15552776 (carcinogen)
  Authors
Sasco AJ, Secretan MB, Straif K.
  Title
Tobacco smoking and cancer: a brief review of recent epidemiological evidence.
  Journal
Lung Cancer 45 Suppl 2:S3-9 (2004)
DOI:10.1016/j.lungcan.2004.07.998
Reference
PMID:12612656 (marker)
  Authors
Baldwin P, Laskey R, Coleman N.
  Title
Translational approaches to improving cervical screening.
  Journal
Nat Rev Cancer 3:217-26 (2003)
DOI:10.1038/nrc1010
Reference
PMID:12797857 (marker)
  Authors
Garland SM.
  Title
Can we really beat cervical cancer?
  Journal
Med J Aust 178:647-9 (2003)
Reference
PMID:14739059 (marker)
  Authors
Gadducci A, Cosio S, Carpi A, Nicolini A, Genazzani AR.
  Title
Serum tumor markers in the management of ovarian, endometrial and cervical cancer.
  Journal
Biomed Pharmacother 58:24-38 (2004)
DOI:10.1016/j.biopha.2003.11.003
Reference
(drug)
  Authors
Papadakis MA and McPhee SJ |(ed)
  Title
Current Medical Diagnosis & Treatment 2015, Fifty-Fourth Edition
  Journal
McGraw Hill Education

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