KEGG   DISEASE: Squamous cell carcinoma
Entry
H00040                      Disease                                
Name
Squamous cell carcinoma
Description
Non-melanoma skin cancer, i.e. basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) are the most frequent tumors and their number is still increasing world- wide. Approximately 200000 cases of SCC develop per year, causing about 2000 deaths. Unlike BCCs, which have no known precursor lesions, SCCs can emerge from actinic keratoses. As with BCC, risk for development of SCC is strongly influenced by the nature and dose of UV radiation and genetic backgrounds that regulate that interaction. Mutations in TP53 have been described in actinic keratoses, in situ SCC, and invasive SCC with UV signature lesions common, and a reported mutation rate as high as 45%. As with TP53, UV-induced mutations in HRAS and KRAS have also been characterized in both actinic keratoses and SCC. The reported frequency of RAS mutations in SCCs ranges from approximately 10% to almost 50%. Several recent studies have also reported mutations of p16 in up to 24% of SCCs. In addition to UV, a pathogenic role for human papillomavirus (HPV) in the development of SCC has also been proposed.
Category
Cancer
Brite
Human diseases in ICD-11 classification [BR:br08403]
 02 Neoplasms
  Malignant neoplasms, except primary neoplasms of lymphoid, haematopoietic, central nervous system or related tissues
   Malignant neoplasms, stated or presumed to be primary, of specified sites, except of lymphoid, haematopoietic, central nervous system or related tissues
    Malignant neoplasms of skin
     2C31  Squamous cell carcinoma of skin
      H00040  Squamous cell carcinoma
Gene
p53 (mutation) [HSA:7157] [KO:K04451]
p16/INK4A (mutation) [HSA:1029] [KO:K06621]
H-ras (mutation) [HSA:3265] [KO:K02833]
K-ras (mutation) [HSA:3845] [KO:K07827]
Pathogen
Human papillomavirus types 5, 8 [GN:T40089]
Drug
Bleomycin sulfate [DR:D02177]
Pembrolizumab [DR:D10574]
Cemiplimab [DR:D11108]
Other DBs
ICD-11: 2C31
ICD-10: C44
MeSH: D002294
Reference
  Authors
Tsai KY, Tsao H.
  Title
The genetics of skin cancer.
  Journal
Am J Med Genet C Semin Med Genet 131C:82-92 (2004)
DOI:10.1002/ajmg.c.30037
Reference
  Authors
Tsao H.
  Title
Genetics of nonmelanoma skin cancer.
  Journal
Arch Dermatol 137:1486-92 (2001)
DOI:10.1001/archderm.137.11.1486
Reference
  Authors
Accardi R, Gheit T
  Title
Cutaneous HPV and skin cancer.
  Journal
Presse Med 43:e435-43 (2014)
DOI:10.1016/j.lpm.2014.08.008
Reference
  Authors
Nindl I, Gottschling M, Stockfleth E
  Title
Human papillomaviruses and non-melanoma skin cancer: basic virology and clinical manifestations.
  Journal
Dis Markers 23:247-59 (2007)
DOI:10.1155/2007/942650
Reference
  Authors
Tiu J, Li H, Rassekh C, van der Sloot P, Kovach R, Zhang P.
  Title
Molecular basis of posttransplant squamous cell carcinoma: the potential role of cyclosporine a in carcinogenesis.
  Journal
Laryngoscope 116:762-9 (2006)
DOI:10.1097/01.mlg.0000205170.24517.28
Reference
  Authors
Luch A.
  Title
Nature and nurture - lessons from chemical carcinogenesis.
  Journal
Nat Rev Cancer 5:113-25 (2005)
DOI:10.1038/nrc1546
Reference
  Authors
Abnet CC.
  Title
Carcinogenic food contaminants.
  Journal
Cancer Invest 25:189-96 (2007)
DOI:10.1080/07357900701208733
Reference
PMID:9498904
  Authors
Boffetta P, Jourenkova N, Gustavsson P.
  Title
Cancer risk from occupational and environmental exposure to polycyclic aromatic hydrocarbons.
  Journal
Cancer Causes Control 8:444-72 (1997)
DOI:10.1023/a:1018465507029
Reference
PMID:9498901
  Authors
Tolbert PE.
  Title
Oils and cancer.
  Journal
Cancer Causes Control 8:386-405 (1997)
DOI:10.1023/a:1018409422050
Reference
  Authors
Takeuchi Y, Tamura A, Kamiya M, Fukuda T, Ishikawa O.
  Title
Immunohistochemical analyses of p63 expression in cutaneous tumours.
  Journal
Br J Dermatol 153:1230-2 (2005)
DOI:10.1111/j.1365-2133.2005.06952.x
Reference
  Authors
Park HR, Min SK, Cho HD, Kim KH, Shin HS, Park YE.
  Title
Expression profiles of p63, p53, survivin, and hTERT in skin tumors.
  Journal
J Cutan Pathol 31:544-9 (2004)
DOI:10.1111/j.0303-6987.2004.00228.x

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