KEGG DISEASE: Cancer of the anal canal

DISEASE: Cancer of the anal canal

Entry

H00044                      Disease

Name

Cancer of the anal canal

Description

Squamous cell carcinoma of the anal canal accounts for 1.5 per cent of all digestive system cancers in the USA, with an estimated 4,660 new cases and 660 deaths in 2006. Epidemiological and molecular-biology studies have now shown that sexually transmitted infection with human papillomavirus (HPV) is the most important aetiological agent. Human immunodeficiency virus (HIV) infection is also associated with anal cancer. HPV infection is transient in most immunocompetent individuals, but HIV-positive patients have evidence of persistent HPV infection within the anal canal. Current data suggest that mutations in p53, DCC and APC tumor suppressor genes contribute to the stepwise progression of anal squamous cell carcinoma in immunocompetent individuals.

Category

Cancer

Brite

Human diseases in ICD-11 classification [BR:br08403]
02 Neoplasms
  Malignant neoplasms, except primary neoplasms of lymphoid, haematopoietic, central nervous system or related tissues
   Malignant neoplasms, stated or presumed to be primary, of specified sites, except of lymphoid, haematopoietic, central nervous system or related tissues
    Malignant neoplasms of digestive organs
     Malignant neoplasms of intestine
      2C00  Malignant neoplasms of anus or anal canal
       H00044  Cancer of the anal canal

Pathway

hsa05165

Human papillomavirus infection

Gene

p53 (mutation) [HSA:7157] [KO:K04451]
DCC (mutation) [HSA:1630] [KO:K06765]
APC (mutation) [HSA:324] [KO:K02085]

Pathogen

Human papillomavirus type 16 [GN:T40087]
Human papillomavirus type 18 [GN:T40088]

Drug

Recombinant adsorbed quadrivalent human papillomavirus virus-like particle vaccine [DR:D10192]
Human papillomavirus 9-valent vaccine, recombinant [DR:D11863]

Other DBs

ICD-11:

2C00

ICD-10:

C21

MeSH:

D001005

Reference

PMID:16607677

Authors

Gervaz P, Hirschel B, Morel P.

Title

Molecular biology of squamous cell carcinoma of the anus.

Journal

Br J Surg 93:531-8 (2006)
DOI:10.1002/bjs.5376

Reference

PMID:12947531

Authors

Gervaz P, Allal AS, Villiger P, Buhler L, Morel P.

Title

Squamous cell carcinoma of the anus: another sexually transmitted disease.

Journal

Swiss Med Wkly 133:353-9 (2003)

Reference

PMID:11281434

Authors

Severson J, Evans TY, Lee P, Chan T, Arany I, Tyring SK.

Title

Human papillomavirus infections: epidemiology, pathogenesis, and therapy.

Journal

J Cutan Med Surg 5:43-60 (2001)
DOI:10.1177/120347540100500110

Reference

PMID:1311142

Authors

Daling JR, Sherman KJ, Hislop TG, Maden C, Mandelson MT, Beckmann AM, Weiss NS.

Title

Cigarette smoking and the risk of anogenital cancer.

Journal

Am J Epidemiol 135:180-9 (1992)
DOI:10.1093/oxfordjournals.aje.a116270

Reference

PMID:17255774

Authors

Owens SR, Greenson JK.

Title

Immunohistochemical staining for p63 is useful in the diagnosis of anal squamous cell carcinomas.

Journal

Am J Surg Pathol 31:285-90 (2007)
DOI:10.1097/01.pas.0000213362.10756.d3

Reference

PMID:9372374

Authors

Indinnimeo M, Reale MG, Cicchini C, Stazi A, Fiori E, Izzo P.

Title

CEA, TPA, CA 19-9, SCC and CYFRA at diagnosis and in the follow-up of anal canal tumors.

Journal

Int Surg 82:275-9 (1997)

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Drug (2)   
   KEGG DRUG (2)   
Genome (2)   
   KEGG GENOME (2)   
Gene (6)   
   KEGG ORTHOLOGY (3)   
   KEGG GENES (3)   
Literature (6)   
   PubMed (6)   
All databases (16)   

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