KEGG DISEASE: Laryngeal cancer

DISEASE: Laryngeal cancer

Entry

H00055                      Disease

Name

Laryngeal cancer

Supergrp

Head and neck cancer [DS:H02420]
Solid tumor [DS:H02421]

Description

Laryngeal cancer is one of the most common malignancies in Europe, with about 52,000 new cases per year, 90% of them occurring in men. Smoke and alcohol represent the major behavioral risk factors. Of all laryngeal cancers, some 95% are squamous cell carcinomas. Some molecular events have been described in laryngeal squamous cell carcinoma (LSCC). Although tumor suppressor inactivation of p53 and p16 is common in these tumors (about 50% each), oncogenic activation is less well characterized. Cyclin D1 and epidermal growth factor receptor amplification have been reported in one-third and one-quarter of LSCCs, respectively, both related to advanced stages, whereas c-myc could be amplified in 13% of cases although without associated overexpression.

Category

Cancer

Brite

Human diseases in ICD-11 classification [BR:br08403]
02 Neoplasms
  Malignant neoplasms, except primary neoplasms of lymphoid, haematopoietic, central nervous system or related tissues
   Malignant neoplasms, stated or presumed to be primary, of specified sites, except of lymphoid, haematopoietic, central nervous system or related tissues
    Malignant neoplasms of middle ear, respiratory or intrathoracic organs
     2C23  Malignant neoplasms of larynx
      H00055  Laryngeal cancer

Gene

p53 (mutation) [HSA:7157] [KO:K04451]
p16/INK4A (mutation, LOH, hypermethylation) [HSA:1029] [KO:K06621]
Cyclin D1 (amplification) [HSA:595] [KO:K04503]
EGFR (amplification) [HSA:1956] [KO:K04361]
c-MYC (amplification) [HSA:4609] [KO:K04377]
Cyclin E (amplification) [HSA:898 9134] [KO:K06626]

Other DBs

ICD-11:

2C23

MeSH:

D007822

Reference

PMID:12853099

Authors

Licitra L, Bernier J, Grandi C, Locati L, Merlano M, Gatta G, Lefebvre JL

Title

Cancer of the larynx.

Journal

Crit Rev Oncol Hematol 47:65-80 (2003)
DOI:10.1016/S1040-8428(03)00017-9

Reference

PMID:12536308

Authors

Nadal A, Cardesa A.

Title

Molecular biology of laryngeal squamous cell carcinoma.

Journal

Virchows Arch 442:1-7 (2003)
DOI:10.1007/s00428-002-0726-6

Reference

PMID:17530489

Authors

Abnet CC.

Title

Carcinogenic food contaminants.

Journal

Cancer Invest 25:189-96 (2007)
DOI:10.1080/07357900701208733

Reference

PMID:17646865

Authors

Seitz HK, Stickel F.

Title

Molecular mechanisms of alcohol-mediated carcinogenesis.

Journal

Nat Rev Cancer 7:599-612 (2007)
DOI:10.1038/nrc2191

Reference

PMID:15957167

Authors

Lee KW, Kuo WR, Tsai SM, Wu DC, Wang WM, Fang FM, Chiang FY, Ho KY, Wang LF, Tai CF, Kao EL, Chou SH, Lee CH, Chai CY, Ko YC.

Title

Different impact from betel quid, alcohol and cigarette: risk factors for pharyngeal and laryngeal cancer.

Journal

Int J Cancer 117:831-6 (2005)
DOI:10.1002/ijc.21237

Reference

PMID:9498904

Authors

Boffetta P, Jourenkova N, Gustavsson P.

Title

Cancer risk from occupational and environmental exposure to polycyclic aromatic hydrocarbons.

Journal

Cancer Causes Control 8:444-72 (1997)
DOI:10.1023/a:1018465507029

Reference

PMID:8189372

Authors

Wong O, Foliart DE.

Title

Epidemiological factors of cancer in Louisiana.

Journal

J Environ Pathol Toxicol Oncol 12:171-83 (1993)

Reference

PMID:9498901

Authors

Tolbert PE.

Title

Oils and cancer.

Journal

Cancer Causes Control 8:386-405 (1997)
DOI:10.1023/a:1018409422050

Reference

PMID:10723042

Authors

Stern FB, Ruder AM, Chen G.

Title

Proportionate mortality among unionized roofers and waterproofers.

Journal

Am J Ind Med 37:478-92 (2000)
DOI:10.1002/(SICI)1097-0274(200005)37:5<478::AID-AJIM4>3.0.CO;2-8

Reference

PMID:17032693

Authors

Hsu YM, Wu CY, Lundgren DA, Birky BK.

Title

Size-resolved sulfuric acid mist concentrations at phosphate fertilizer manufacturing facilities in Florida.

Journal

Ann Occup Hyg 51:81-9 (2007)
DOI:10.1093/annhyg/mel066

Reference

PMID:9498905

Authors

Blair A, Kazerouni N.

Title

Reactive chemicals and cancer.

Journal

Cancer Causes Control 8:473-90 (1997)
DOI:10.1023/a:1018417623867

Reference

PMID:15489140

Authors

Wogan GN, Hecht SS, Felton JS, Conney AH, Loeb LA.

Title

Environmental and chemical carcinogenesis.

Journal

Semin Cancer Biol 14:473-86 (2004)
DOI:10.1016/j.semcancer.2004.06.010

Reference

PMID:15552776

Authors

Sasco AJ, Secretan MB, Straif K.

Title

Tobacco smoking and cancer: a brief review of recent epidemiological evidence.

Journal

Lung Cancer 45 Suppl 2:S3-9 (2004)
DOI:10.1016/j.lungcan.2004.07.998

Reference

PMID:10764231

Authors

Greenman J, Homer JJ, Stafford ND.

Title

Markers in cancer of the larynx and pharynx.

Journal

Clin Otolaryngol Allied Sci 25:9-18 (2000)
DOI:10.1046/j.1365-2273.2000.00339.x

Reference

PMID:15763643

Authors

Almadori G, Bussu F, Cadoni G, Galli J, Paludetti G, Maurizi M.

Title

Molecular markers in laryngeal squamous cell carcinoma: towards an integrated clinicobiological approach.

Journal

Eur J Cancer 41:683-93 (2005)
DOI:10.1016/j.ejca.2004.10.031

Reference

PMID:11016683

Authors

Nylander K, Dabelsteen E, Hall PA.

Title

The p53 molecule and its prognostic role in squamous cell carcinomas of the head and neck.

Journal

J Oral Pathol Med 29:413-25 (2000)
DOI:10.1034/j.1600-0714.2000.290901.x

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