KEGG   DISEASE: Haemophilus influenzae infection
Entry
H00304                      Disease                                

Name
Haemophilus influenzae infection
Description
Haemophilus influenzae type b (Hib) infections are a major cause of severe infections in children between 2 months and 5 years of age worldwide. It affects approximately 25000 patients each year. Severity of the symptoms of Hib infection depends on the patient's age, and infants between 4 months and 1 year of age are at highest risk for meningitis. Invasive disease due to Hib may produce various clinical syndromes including meningitis, arthritis, pneumonia, cellulitis, osteomyelitis, and epiglottitis. Mucosal infections, such as bronchitis, sinusitis and conjunctivitis, and otitis media, can also be caused by Hib, but they are considered to be noninvasive disease.
Category
Infectious disease
Brite
Infectious diseases [BR:br08401]
 Bacterial infections
  Infections caused by other gamma proteobacteria
   H00304  Haemophilus influenzae infection
Human diseases in ICD-11 classification [BR:br08403]
 01 Certain infectious or parasitic diseases
  Non-viral and unspecified infections of the central nervous system
   1D01  Infectious meningitis not elsewhere classified
    H00304  Haemophilus influenzae infection
 12 Diseases of the respiratory system
  Lung infections
   CA40  Pneumonia
    H00304  Haemophilus influenzae infection
   CA42  Acute bronchitis
    H00304  Haemophilus influenzae infection
Pathogen
Haemophilus influenzae [GN:hin hit hip hiq hiu hik hih]
Comment
American Indians and Alaskan Eskimos are at increased risk specifically for meningitis caused by Hib.
Other DBs
ICD-11: 1D01.00 CA40.02 CA42.4
ICD-10: A41.3 A49.2 G00.0 J14 J20.1
MeSH: D006192
Reference
PMID:2194406 (description, drug, comment)
  Authors
Janai H, Stutman HR, Marks MI
  Title
Invasive Haemophilus influenzae type B infections: a continuing challenge.
  Journal
Am J Infect Control 18:160-6 (1990)
DOI:10.1016/0196-6553(90)90181-Q
Reference
PMID:22244051 (drug)
  Authors
Ladhani SN
  Title
Two decades of experience with the Haemophilus influenzae serotype b conjugate vaccine in the United Kingdom.
  Journal
Clin Ther 34:385-99 (2012)
DOI:10.1016/j.clinthera.2011.11.027
Reference
PMID:20980793 (drug)
  Authors
Fitzwater SP, Watt JP, Levine OS, Santosham M
  Title
Haemophilus influenzae type b conjugate vaccines: considerations for vaccination schedules and implications for developing countries.
  Journal
Hum Vaccin 6:810-8 (2010)
DOI:10.4161/hv.6.10.13017
Reference
PMID:3325012 (drug)
  Authors
Gilbert GL
  Title
Epidemiology and prevention of invasive Haemophilus influenzae type b infection.
  Journal
Aust Paediatr J 23:323-7 (1987)
DOI:10.1111/j.1440-1754.1987.tb00283.x

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