KEGG   DISEASE: LegionellosisHelp
Entry
H00311                      Disease                                

Name
Legionellosis;
Legionnaires disease
Description
Legionnaires disease (LD), caused by Gram-negative Legionella spp., can be nosocomial, community acquired or travel related. L. pneumophila is the most common cause of LD. The source of LD is potable water systems that become colonized by the microorganism, transmitted by inhalation of contaminated aerosols and aspiration. Classically, it can cause two different forms of disease in humans: LD, with an incubation period of 2-10 days, which is a multisystem illness that involves the lungs, causing pneumonia, and can cause neurological symptoms, diarrhea and high mortality (up to 50%), and Pontiac fever, with a shorter incubation period of 1-2 days, which is an acute, self-limited, influenza-like disease that does not cause pneumonia. Patients who are at risk for infection include the immunosuppressed, especially those submitted to transplantation (mainly of solid organs), those with chronic lung disease, smokers, and the elderly.
Category
Infectious disease
Brite
Infectious diseases [BR:br08401]
 Bacterial infections
  Infections caused by other gamma proteobacteria
   H00311  Legionellosis
Human diseases in ICD-11 classification [BR:br08403]
 1. Certain infectious and parasitic diseases (A00-B99)
  A30-A49  Other bacterial diseases
   A48  Other bacterial diseases, not elsewhere classified
    H00311  Legionellosis
BRITE hierarchy
Pathway
hsa05134  Legionellosis
Pathogen
Legionella pneumophila [GN:lpn lpf lpp lpc lpa lpe]
Legionella longbeachae [GN:llo]
Legionella sainthelensi [GN:lsh]
pore-forming toxin [KO:K11022]
Drug
Erythromycin [DR:D00140]
Erythromycin ethylsuccinate [DR:D01361]
Erythromycin lactobionate [DR:D02009]
Erythromycin stearate [DR:D02184]
Other DBs
ICD-11: 1C19
ICD-10: A48.1 A48.2
MeSH: D007876 D007877
MedlinePlus: 000616
Reference
  Authors
Roig J, Sabria M, Pedro-Botet ML
  Title
Legionella spp.: community acquired and nosocomial infections.
  Journal
Curr Opin Infect Dis 16:145-51 (2003)
DOI:10.1097/01.aco.0000065081.06965.cf
Reference
  Authors
Carratala J, Garcia-Vidal C
  Title
An update on Legionella.
  Journal
Curr Opin Infect Dis 23:152-7 (2010)
DOI:10.1097/QCO.0b013e328336835b
Reference
  Authors
Blyth CC, Adams DN, Chen SC
  Title
Diagnostic and typing methods for investigating Legionella infection.
  Journal
N S W Public Health Bull 20:157-61 (2009)
DOI:10.1071/NB08062
Reference
  Authors
Levin AS
  Title
Nosocomial legionellosis: prevention and management.
  Journal
Expert Rev Anti Infect Ther 7:57-68 (2009)
DOI:10.1586/14787210.7.1.57

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