KEGG   DISEASE: Methicillin-resistant Staphylococcal aureus (MRSA) infectionHelp
Entry
H00330                      Disease                                

Name
Methicillin-resistant Staphylococcal aureus (MRSA) infection
Description
Methicillin-resistant Staphylococcus aureus (MRSA) is one of the major multidrug-resistant bacteria which have become endemic in the hospital environment, particularly in intensive care units (ICUs). Originally limited to the hospital setting, MRSA is a growing cause of infections in the community. Community-associated MRSA (CA-MRSA) strains are genetically different from MRSA strains originating in the hospital. Its increase in the community is of concern because CA-MRSA strains appear to be highly virulent, and colonization with CA-MRSA is often undetected in hospitalized patients, which can facilitate its potential for becoming resistant to multiple antibiotics. Health care-associated MRSA (HA-MRSA) is usually associated with pneumonia, urinary tract, blood stream, and surgical wound infections. In contrast, CA-MRSA strains are overwhelmingly associated with skin and soft tissue infections.
Category
Infectious disease
Brite
Infectious diseases [BR:br08401]
 Bacterial infections
  Infections caused by Gram-positive bacteria
   H00330  Methicillin-resistant Staphylococcal aureus (MRSA) infection
Human diseases in ICD-11 classification [BR:br08403]
 21 Symptoms, signs or clinical findings, not elsewhere classified
  General symptoms, signs or clinical findings
   Finding of microorganism resistant to antimicrobial drugs
    MG51  Finding of gram positive bacteria resistant to antimicrobial drugs
     H00330  Methicillin-resistant Staphylococcal aureus (MRSA) infection
BRITE hierarchy
Pathway
hsa05150  Staphylococcus aureus infection
Pathogen
Staphylococcus aureus [GN:sau sav saw sah sar sac suk sut sux suw sug sauz saut sauj sauk sauq sauv sauw saux sauy saum saur] (hospital-acquired MRSA)
Staphylococcus aureus [GN:sam sax saa suu suj suz saun sauu saug] (community-acquired MRSA)
  Module
M00625  Methicillin resistance
Drug
Vancomycin hydrochloride [DR:D00926]
Mupirocin calcium [DR:D02195]
Other DBs
ICD-11: MG51.00
ICD-10: U82.1
MeSH: D013203
MedlinePlus: 007261
Reference
  Authors
Otto M
  Title
Basis of virulence in community-associated methicillin-resistant Staphylococcus aureus.
  Journal
Annu Rev Microbiol 64:143-62 (2010)
DOI:10.1146/annurev.micro.112408.134309
Reference
  Authors
Chavez TT, Decker CF
  Title
Health care-associated MRSA versus community-associated MRSA.
  Journal
Dis Mon 54:763-8 (2008)
DOI:10.1016/j.disamonth.2008.09.004
Reference
  Authors
Henderson DK
  Title
Managing methicillin-resistant staphylococci: a paradigm for preventing nosocomial transmission of resistant organisms.
  Journal
Am J Infect Control 34:S46-54: discussion S64-73 (2006)
DOI:10.1016/j.ajic.2006.05.228

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