KEGG   DISEASE: Bacterial endocarditis
Entry
H00334                      Disease                                

Name
Bacterial endocarditis;
Infective endocarditis
Description
Infective endocarditis is a microbial infection of the endocardial surface of the heart. The characteristic lesion, a vegetation, is composed of a collection of platelets, fibrin, microorganisms, and inflammatory cells. It most commonly involves heart valves but may also occur at the site of a septal defect, on the chordae tendineae, or on the mural endocardium. Staphylococci and streptococci account for 80% of cases of infective endocarditis, with staphylococci currently the most common pathogens. Cerebral complications are the most frequent and most severe extracardiac complications.
Category
Infectious disease
Brite
Infectious diseases [BR:br08401]
 Bacterial infections
  Infections caused by bacteria
   H00334  Bacterial endocarditis
Pathogen
Streptococcus viridans
Streptococcus sanguinis [GN:ssa]
Streptococcus suis [GN:ssu ssv]
Streptococcus gordonii [GN:sgo]
Staphylococcus aureus [GN:sah saj sug]
Enterococcus
Corynebacterium diphtheriae [GN:cdt cde cdr cda]
Rothia aeria [GN:raj]
Aggregatibacter aphrophilus [GN:aap]
Aggregatibacter actinomycetemcomitans [GN:aat aao aan]
Cardiobacterium hominis
Eikenella corrodens
Kingella kingae
superantigen [KO:K11040 K11041 K11042 K11043]
pore-forming toxin [KO:K11031 K11032 K11038 K11039]
membrane-damaging toxin [KO:K01114]
Drug
Metronidazole [DR:D00409]
Streptomycin sulfate [DR:D01350]
Vancomycin hydrochloride [DR:D00926]
Gentamicin sulfate [DR:D01063]
Erythromycin lactobionate [DR:D02009]
Ampicillin sodium [DR:D02119]
Penicillin G potassium [DR:D01053]
Penicillin G procaine [DR:D02461]
Penicillin G sodium [DR:D05408]
Cefazolin sodium [DR:D00905]
Imipenem and cilastatin sodium [DR:D00344]
Daptomycin [DR:D01080]
Other DBs
ICD-10: I39.8
MeSH: D004697
MedlinePlus: 000681
Reference
(drug)
  Authors
Papadakis MA and McPhee SJ |(ed)
  Title
Current Medical Diagnosis & Treatment 2007, Forty-Sixth Edition
  Journal
McGraw Hill Education
Reference
  Authors
Beynon RP, Bahl VK, Prendergast BD
  Title
Infective endocarditis.
  Journal
BMJ 333:334-9 (2006)
DOI:10.1136/bmj.333.7563.334
Reference
  Authors
Hoen B, Duval X
  Title
Clinical practice. Infective endocarditis.
  Journal
N Engl J Med 368:1425-33 (2013)
DOI:10.1056/NEJMcp1206782
Reference
  Authors
Mylonakis E, Calderwood SB
  Title
Infective endocarditis in adults.
  Journal
N Engl J Med 345:1318-30 (2001)
DOI:10.1056/NEJMra010082

» Japanese version

DBGET integrated database retrieval system