KEGG   DISEASE: Gas gangrene
Entry
H00336                      Disease                                

Name
Gas gangrene;
Clostridial myonecrosis
  Supergrp
Anaerobic infection [DS:H01410]
Description
Gas gangrene is a rare and devastating wound infection. The Clostridium perfringens, septicum, and histolyticum are the principal causes of trauma-associated gas gangrene. It is characterized by fever, pain, edema, myonecrosis and gas production. Recently, there has also been an increased incidence of spontaneous gas gangrene caused by Clostridium septicum.
Category
Infectious disease
Brite
Infectious diseases [BR:br08401]
 Bacterial infections
  Infections caused by Gram-positive bacteria
   H00336  Gas gangrene
Human diseases in ICD-11 classification [BR:br08403]
 01 Certain infectious or parasitic diseases
  Other bacterial diseases
   1C16  Gas gangrene
    H00336  Gas gangrene
Pathogen
Clostridium perfringens [GN:cpe cpf cpr]
hyaluronidase/collagenase [KO:K01186 K01197 K01387 K08587]
pore-forming toxin [KO:K03699 K06442 K11031 K11058 K11068]
membrane-damaging toxin [KO:K16619]
enterotoxin [KO:K11059 K11060 K11061 K11062]
beta2 toxin [KO:K11057]
Drug
Penicillin G potassium [DR:D01053]
Penicillin G sodium [DR:D05408]
Other DBs
ICD-11: 1C16
ICD-10: A48.0
MeSH: D005738
MedlinePlus: 000620
Reference
  Authors
MACLENNAN JD
  Title
The histotoxic clostridial infections of man.
  Journal
Bacteriol Rev 26:177-276 (1962)
Reference
  Authors
Sasaki T, Nanjo H, Takahashi M, Sugiyama T, Ono I, Masuda H
  Title
Non-traumatic gas gangrene in the abdomen: report of six autopsy cases.
  Journal
J Gastroenterol 35:382-90 (2000)
DOI:10.1007/s005350050365
Reference
  Authors
Stevens DL, Aldape MJ, Bryant AE
  Title
Life-threatening clostridial infections.
  Journal
Anaerobe 18:254-9 (2012)
DOI:10.1016/j.anaerobe.2011.11.001

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