KEGG   DISEASE: Pituitary adenomasHelp
Entry
H01102                      Disease                                

Name
Pituitary adenomas
  Subgroup
Multiple endocrine neoplasia type 1 (MEN1)
MEN1-like syndrome (MEN4)
Carney complex (CNC) [DS:H01820]
Familial isolated pituitary adenomas (FIPA)
  Supergrp
Cushing syndrome [DS:H01431]
Description
Pituitary adenomas are an important and frequently occurring form of intracranial tumor. They are usually benign but can give rise to severe clinical syndromes due to hormonal excess, or to visual/cranial disturbances due to mass effect. The tumor can be clinically nonfunctioning or hormone secreting. Among the latter, prolactin (PRL) and growth hormone (GH)-secreting adenomas are the most common. The majority of pituitary adenomas arise sporadically, although a subset occurs as component tumors of well-characterized familial cancer syndromes, such as multiple endocrine neoplasia type 1 (MEN1), Carney complex (CNC), and MEN1-like syndrome (MEN4).
Category
Endocrine and metabolic disease
Brite
Human diseases [BR:br08402]
 Endocrine and metabolic diseases
  Hypothalamus and pituitary gland diseases
   H01102  Pituitary adenomas
Human diseases in ICD-11 classification [BR:br08403]
 2. Neoplasms (C00-D48)
  D37-D48  Neoplasms of uncertain or unknown behaviour
   D44  Neoplasm of uncertain or unknown behaviour of endocrine glands
    H01102  Pituitary adenomas
BRITE hierarchy
Pathway
hsa05202  Transcriptional misregulation in cancer
hsa04012  ErbB signaling pathway
hsa04110  Cell cycle
hsa04210  Apoptosis
hsa04910  Insulin signaling pathway
Network
N00290  Mutation-inactivated MEN1 to transcription
N00315  Mutation-inactivated AIP to AhR-mediated transcription
N00316  Mutation-inactivated CDKN1B to p27-cell cycle G1/S
N00319  Mutation-activated USP8 to EGFR-ERK-ACTH signaling pathway
N00325  Mutation-inactivated RASD1 to CRHR-PKA-ACTH signaling pathway
N00326  Mutation-activated GNAS to CRHR-PKA-ACTH signaling pathway
N00327  Mutation-inactivated PRKAR1A to CRHR-PKA-ACTH signaling pathway
Gene
(MEN1) MEN1 [HSA:4221] [KO:K14970]
(MEN4) CDKN1B [HSA:1027] [KO:K06624]
(CNC) PRKAR1A [HSA:5573] [KO:K04739]
AIP [HSA:9049] [KO:K17767]
GPR101 [HSA:83550] [KO:K08423]
GNAS [HSA:2778] [KO:K04632]
USP8 [HSA:9101] [KO:K11839]
PIK3CA [HSA:5290] [KO:K00922]
DICER1 [HSA:23405] [KO:K11592]
RASD1 [HSA:51655] [KO:K07843]
Drug
Omeprazole [DR:D00455]
Other DBs
ICD-11: 2F37.0
ICD-10: D44.8
MeSH: D010911
OMIM: 600634 610755 160980 102200 300943 617686 219090
Reference
  Authors
Trivellin G, Korbonits M
  Title
AIP and its interacting partners.
  Journal
J Endocrinol 210:137-55 (2011)
DOI:10.1530/JOE-11-0054
Reference
  Authors
Heliovaara E, Tuupanen S, Ahlsten M, Hodgson S, de Menis E, Kuismin O, Izatt L, McKinlay Gardner RJ, Gundogdu S, Lucassen A, Arola J, Tuomisto A, Makinen M, Karhu A, Aaltonen LA
  Title
No evidence of RET germline mutations in familial pituitary adenoma.
  Journal
J Mol Endocrinol 46:1-8 (2011)
DOI:10.1677/JME-10-0052
Reference
  Authors
Tichomirowa MA, Daly AF, Beckers A
  Title
Familial pituitary adenomas.
  Journal
J Intern Med 266:5-18 (2009)
DOI:10.1111/j.1365-2796.2009.02109.x
Reference
  Authors
Lacroix A, Feelders RA, Stratakis CA, Nieman LK
  Title
Cushing's syndrome.
  Journal
Lancet 386:913-27 (2015)
DOI:10.1016/S0140-6736(14)61375-1
Reference
  Authors
Caimari F, Korbonits M
  Title
Novel Genetic Causes of Pituitary Adenomas.
  Journal
Clin Cancer Res 22:5030-5042 (2016)
DOI:10.1158/1078-0432.CCR-16-0452
Reference
  Authors
Xiong Q, Ge W
  Title
Gene mutations in Cushing's disease.
  Journal
Biomed Rep 5:277-282 (2016)
DOI:10.3892/br.2016.729
Reference
  Authors
Uzilov AV, Cheesman KC, Fink MY, Newman LC, Pandya C, Lalazar Y, Hefti M, Fowkes M, Deikus G, Lau CY, Moe AS, Kinoshita Y, Kasai Y, Zweig M, Gupta A, Starcevic D, Mahajan M, Schadt EE, Post KD, Donovan MJ, Sebra R, Chen R, Geer EB
  Title
Identification of a novel RASD1 somatic mutation in a USP8-mutated corticotroph adenoma.
  Journal
Cold Spring Harb Mol Case Stud 3:a001602 (2017)
DOI:10.1101/mcs.a001602

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