KEGG   DISEASE: Yaws
Entry
H01318                      Disease                                

Name
Yaws
Description
Treponemal infections occurring in humans comprise venereal syphilis and the non-venereal endemic treponematoses. The non-venereal endemic treponematoses are yaws, pinta, and endemic syphilis. Yaws is a chronic, relapsing disease predominantly affecting children living in certain tropical regions. Clinical manifestations of yaws are divided into various stages. Early stage skin lesions are infectious and can persist for weeks or months. Involvement of the bones of the upper and lower limbs and the fingers and toes can cause pain and digital swelling. After the early stage lesions subside due to the host immune response, the patient enters a latent stage that can be lifelong.
Category
Infectious disease
Brite
Infectious diseases [BR:br08401]
 Bacterial infections
  Infections caused by spirochaetes
   H01318  Yaws
Human diseases in ICD-11 classification [BR:br08403]
 01 Certain infectious or parasitic diseases
  Other bacterial diseases
   1C1D  Yaws
    H01318  Yaws
Pathogen
Treponema pallidum subsp. pertenue [GN:tpc tpg tpm]
Drug
Tetracycline hydrochloride [DR:D02122]
Doxycycline [DR:D00307]
Doxycycline hyclate [DR:D02129]
Doxycycline calcium [DR:D03903]
Minocycline hydrochloride [DR:D00850]
Demeclocycline hydrochloride [DR:D00290]
Penicillin G benzathine [DR:D02157]
Penicillin G procaine [DR:D02461]
Comment
See also H01530 Pinta and H01531 Bejel.
Other DBs
ICD-11: 1C1D
ICD-10: A66
MeSH: D015001
MedlinePlus: 001341
Reference
  Authors
Engelkens HJ, Vuzevski VD, Stolz E
  Title
Nonvenereal treponematoses in tropical countries.
  Journal
Clin Dermatol 17:143-52; discussion 105-6 (1999)
DOI:10.1016/S0738-081X(99)00007-3
Reference
  Authors
Stamm LV
  Title
Yaws: 110 years after Castellani's discovery of Treponema pallidum subspecies pertenue.
  Journal
Am J Trop Med Hyg 93:4-6 (2015)
DOI:10.4269/ajtmh.15-0147
Reference
PMID:11825779 (pathogen)
  Authors
Antal GM, Lukehart SA, Meheus AZ
  Title
The endemic treponematoses.
  Journal
Microbes Infect 4:83-94 (2002)
DOI:10.1016/S1286-4579(01)01513-1

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