KEGG   DISEASE: Atopic dermatitis
Entry
H01358                      Disease                                

Name
Atopic dermatitis
Description
Atopic dermatitis (AD) is a relapsing chronic inflammatory skin disease characterized by eczematous skin lesions and intense pruritus. A genetic defect in the filaggrin (FLG) protein and/or environmental factors are thought to cause AD by disrupting the epidermis. This disruption, in turn, results in contact between immune cells in the dermis and antigens from the external environment leading to intense itching, scratching, and inflammation. Apart from FLG, recent genome-wide association studies (GWASs) have identified many susceptibility loci of atopic dermatitis with genome-wide significance.
Category
Immune system disease
Brite
Human diseases [BR:br08402]
 Immune system diseases
  Allergies and autoimmune diseases
   H01358  Atopic dermatitis
 Skin diseases
  Skin and soft tissue diseases
   H01358  Atopic dermatitis
Human diseases in ICD-11 classification [BR:br08403]
 14 Diseases of the skin
  Inflammatory dermatoses
   Dermatitis and eczema
    EA80  Atopic eczema
     H01358  Atopic dermatitis
Gene
FLG (mutation) [HSA:2312] [KO:K10384]
IL4 (polymorphism) [HSA:3656] [KO:K04731]
IL4RA (polymorphism) [HSA:3566] [KO:K05071]
SPINK5 (polymorphism) [HSA:11005] [KO:K23420]
IL13 (polymorphism) [HSA:3596] [KO:K05435]
RANTES (polymorphism) [HSA:6352] [KO:K12499]
NOD1 (polymorphism) [HSA:10392] [KO:K08727]
CARD15 (polymorphism) [HSA:64127] [KO:K10165]
TLR-2 (polymorphism) [HSA:7097] [KO:K10159]
TLR-9 (polymorphism) [HSA:54106] [KO:K10161]
COL29A1 (polymorphism) [HSA:256076] [KO:K06238]
Env factor
Soap
Detergent
Proteases from house dust mites
Topical corticosteroids
Pathogen
Staphylococcus aureus
Malassezia sympodialis [GN:msym]
Drug
Triamcinolone acetonide [DR:D00983]
Dexamethasone [DR:D00292]
Dexamethasone sodium phosphate [DR:D00975]
Hydrocortisone [DR:D00088]
Hydrocortisone sodium succinate [DR:D00978]
Hydrocortisone butyrate [DR:D01619]
Prednisolone [DR:D00472]
Prednisolone sodium phosphate [DR:D00981]
Prednisone [DR:D00473]
Doxepin hydrochloride [DR:D00814]
Methylprednisolone [DR:D00407]
Methylprednisolone sodium succinate [DR:D00751]
Methylprednisolone acetate [DR:D00979]
Desonide [DR:D03696]
Tacrolimus [DR:D00107]
Pimecrolimus [DR:D05480]
Dupilumab [DR:D10354]
Crisaborole [DR:D10873]
Cortisone acetate [DR:D00973]
Hydroxyzine hydrochloride [DR:D00672]
Hydroxyzine pamoate [DR:D01096]
Other DBs
ICD-11: EA80
ICD-10: L20
MeSH: D003876
OMIM: 605803
Reference
  Authors
Kabashima K
  Title
New concept of the pathogenesis of atopic dermatitis: interplay among the barrier, allergy, and pruritus as a trinity.
  Journal
J Dermatol Sci 70:3-11 (2013)
DOI:10.1016/j.jdermsci.2013.02.001
Reference
  Authors
Tamari M, Tanaka S, Hirota T
  Title
Genome-wide association studies of allergic diseases.
  Journal
Allergol Int 62:21-8 (2013)
DOI:10.2332/allergolint.13-RAI-0539
Reference
  Authors
Bussmann C, Weidinger S, Novak N
  Title
Genetics of atopic dermatitis.
  Journal
J Dtsch Dermatol Ges 9:670-6 (2011)
DOI:10.1111/j.1610-0387.2011.07656.x
Reference
  Authors
Barnes KC
  Title
An update on the genetics of atopic dermatitis: scratching the surface in 2009.
  Journal
J Allergy Clin Immunol 125:16-29.e1-11; quiz 30-1 (2010)
DOI:10.1016/j.jaci.2009.11.008
Reference
  Authors
Berke R, Singh A, Guralnick M
  Title
Atopic dermatitis: an overview.
  Journal
Am Fam Physician 86:35-42 (2012)
Reference
PMID:16815133 (env_factor)
  Authors
Cork MJ, Robinson DA, Vasilopoulos Y, Ferguson A, Moustafa M, MacGowan A, Duff GW, Ward SJ, Tazi-Ahnini R
  Title
New perspectives on epidermal barrier dysfunction in atopic dermatitis: gene-environment interactions.
  Journal
J Allergy Clin Immunol 118:3-21; quiz 22-3 (2006)
DOI:10.1016/j.jaci.2006.04.042
Reference
PMID:22586797 (drug)
  Authors
Cookson H, Smith C
  Title
Systemic treatment of adult atopic dermatitis.
  Journal
Clin Med 12:172-6 (2012)
DOI:10.1038/ng1767
Reference
PMID:20070141 (drug)
  Authors
Simpson EL
  Title
Atopic dermatitis: a review of topical treatment options.
  Journal
Curr Med Res Opin 26:633-40 (2010)
DOI:10.1185/03007990903512156
Reference
PMID:24354911 (drug)
  Authors
Simon D, Bieber T
  Title
Systemic therapy for atopic dermatitis.
  Journal
Allergy 69:46-55 (2014)
DOI:10.1111/all.12339

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