KEGG   DISEASE: VitiligoHelp
Entry
H01372                      Disease                                

Name
Vitiligo
Description
Vitiligo is a common, multifactorial, polygenic disease in which autoimmune loss of melanocytes results in depigmented spots of skin, overlying hair, and mucous membranes. Some familial forms of vitiligo have recently been linked to polymorphisms in the innate immunity gene, NLRP1.
Category
Skin and connective tissue disease
Brite
Human diseases [BR:br08402]
 Skin diseases
  Skin and soft tissue diseases
   H01372  Vitiligo
Human diseases in ICD-11 classification [BR:br08403]
 14 Diseases of the skin
  Skin disorders involving specific cutaneous structures
   Disorders of the epidermis and epidermal appendages
    Disorders of skin colour
     ED63  Acquired hypomelanotic disorders
      H01372  Vitiligo
BRITE hierarchy
Pathway
hsa04621  NOD-like receptor signaling pathway
Gene
NLRP1 [HSA:22861] [KO:K12798]
Other DBs
ICD-11: ED63.0
ICD-10: L80
MeSH: D014820
OMIM: 606579
Reference
  Authors
Jin Y, Birlea SA, Fain PR, Spritz RA
  Title
Genetic variations in NALP1 are associated with generalized vitiligo in a Romanian population.
  Journal
J Invest Dermatol 127:2558-62 (2007)
DOI:10.1038/sj.jid.5700953
Reference
  Authors
D'Osualdo A, Reed JC
  Title
NLRP1, a regulator of innate immunity associated with vitiligo.
  Journal
Pigment Cell Melanoma Res 25:5-8 (2012)
DOI:10.1111/j.1755-148X.2011.00942.x
Reference
  Authors
Colucci R, Lotti T, Moretti S
  Title
Vitiligo: an update on current pharmacotherapy and future directions.
  Journal
Expert Opin Pharmacother 13:1885-99 (2012)
DOI:10.1517/14656566.2012.712113

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