KEGG   DISEASE: Hyperprolactinemia
Entry
H01388                      Disease                                

Name
Hyperprolactinemia
Description
Hyperprolactinemia unrelated to pregnancy is a disorder characterized by excess production of prolactin (PRL) and may result in infertility, hypogonadism, and galactorrhea. Such nonphysiological hyperprolactinemia is caused mainly by drugs or by tumors in the anterior pituitary gland, which are usually identifiable by means of magnetic resonance imaging (MRI). Some cases are due to prolactinomas and lesions in the pituitary stalk. A human germline PRLR mutation has been found in familial isolated hyperprolactinemia.
Category
Endocrine disease
Brite
Human diseases [BR:br08402]
 Endocrine and metabolic diseases
  Hypothalamus and pituitary gland diseases
   H01388  Hyperprolactinemia
Human diseases in ICD-11 classification [BR:br08403]
 05 Endocrine, nutritional or metabolic diseases
  Endocrine diseases
   Disorders of the pituitary hormone system
    5A60  Hyperfunction of pituitary gland
     H01388  Hyperprolactinemia
Pathway
hsa04151  PI3K-Akt signaling pathway
hsa04630  JAK-STAT signaling pathway
hsa04917  Prolactin signaling pathway
Network
  Element
N00921  Mutation-inactivated PRLR to PRL-JAK-STAT signaling pathway
Gene
PRLR [HSA:5618] [KO:K05081]
Drug
Bromocriptine mesylate [DR:D00780]
Cabergoline [DR:D00987]
Comment
See also H01607.
Other DBs
ICD-11: 5A60.1
ICD-10: E22.1
MeSH: D006966
OMIM: 615555
Reference
  Authors
Newey PJ, Gorvin CM, Cleland SJ, Willberg CB, Bridge M, Azharuddin M, Drummond RS, van der Merwe PA, Klenerman P, Bountra C, Thakker RV
  Title
Mutant prolactin receptor and familial hyperprolactinemia.
  Journal
N Engl J Med 369:2012-20 (2013)
DOI:10.1056/NEJMoa1307557

» Japanese version

DBGET integrated database retrieval system