KEGG   DISEASE: Methicillin-resistant Staphylococcus epidermidis (MRSE) infectionHelp
Entry
H01401                      Disease                                

Name
Methicillin-resistant Staphylococcus epidermidis (MRSE) infection
Description
The genus Staphylococcus known as pathogen of human and other mammals causes various diseases ranging from minor skin infections to life-threatening bacteremia. The two major opportunistic pathogens in the Staphylococcus genus, Staphylococcus aureus and Staphylococcus epidermis, colonize a sizable portion of the human population. S. epidermidis as the predominant species is quite widespread throughout the cutaneous ecosystem, whereas S. aureus colonizes primarily on mucosal surfaces. Staphylococcal infections are commonly caused by S. aureus. However, the infections due to S. epidermidis and other coagulase-negative staphylococci have been also increasing. S. epidermidis is primarily associated with infections of implanted medical devices, such as prosthetic heart valves and joint prostheses. The treatments of staphylococcal infections are complicated by the development of antibiotic resistance, and the remaining effective treatment against most strains of multidrug-resistant staphylococci, including MRSA and MRSE, is the glycopeptide antibiotic vancomycin.
Category
Infectious disease
Brite
Infectious diseases [BR:br08401]
 Bacterial infections
  Infections caused by Gram-positive bacteria
   H01401  Methicillin-resistant Staphylococcus epidermidis (MRSE) infection
Human diseases in ICD-11 classification [BR:br08403]
 21 Symptoms, signs or clinical findings, not elsewhere classified
  General symptoms, signs or clinical findings
   Finding of microorganism resistant to antimicrobial drugs
    MG51  Finding of gram positive bacteria resistant to antimicrobial drugs
     H01401  Methicillin-resistant Staphylococcus epidermidis (MRSE) infection
BRITE hierarchy
Pathogen
Staphylococcus epidermidis [GN:ser]
Other DBs
ICD-11: MG51.Y
ICD-10: B95
Reference
  Authors
Gill SR, Fouts DE, Archer GL, Mongodin EF, Deboy RT, Ravel J, Paulsen IT, Kolonay JF, Brinkac L, Beanan M, Dodson RJ, Daugherty SC, Madupu R, Angiuoli SV, Durkin AS, Haft DH, Vamathevan J, Khouri H, Utterback T, Lee C, Dimitrov G, Jiang L, Qin H, Weidman J, Tran K, Kang K, Hance IR, Nelson KE, Fraser CM.
  Title
Insights on evolution of virulence and resistance from the complete genome analysis of an early methicillin-resistant Staphylococcus aureus strain and a biofilm-producing methicillin-resistant Staphylococcus epidermidis strain.
  Journal
J Bacteriol 187:2426-38 (2005)
DOI:10.1128/JB.187.7.2426-2438.2005
Reference
  Authors
Nomura K, Mizumachi E, Yamashita M, Ohshiro M, Komori T, Sugai M, Taniwaki M, Ishida Y
  Title
Drug susceptibility and clonality of methicillin-resistant Staphylococcus epidermidis in hospitalized patients with hematological malignancies.
  Journal
Ir J Med Sci 179:351-6 (2010)
DOI:10.1007/s11845-010-0481-7

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