KEGG   DISEASE: PellagraHelp
Entry
H01582                      Disease                                

Name
Pellagra
Description
Pellagra is a remarkable chronic wasting disorder, the late stage of a severe cellular deficiency of niacin (vitamin B3). The classical triad of pellagra is dermatitis, diarrhea and dementia. Early symptoms include lassitude, weakness, loss of appetite, mild digestive disturbances and psychiatric distress. The dermatitis caused by pellagra is a bilaterally symmetrical eruption at cutaneous sites of solar exposure. It tends to be painful to touch during the acute phase and can eventually become so clinically striking that the patient may become ostracized. Untreated pellagra results in death from multiorgan failure. Pellagra used to be a disease of epidemic proportions in the developed world. In the 18th century, it was linked with poverty and subsistence on nutritionally marginal corn-based diets. In the 1940s and 1950s, with expanded biochemical knowledge, pellagra was reformulated as a deficiency disease due to inadequate niacin and its amino acid precursor tryptophan. It is currently seen in association with other conditions of chronic nutritional deficiencies, like alcoholism.
Category
Endocrine and metabolic disease
Brite
Human diseases [BR:br08402]
 Endocrine and metabolic diseases
  Other endocrine and metabolic diseases
   H01582  Pellagra
Human diseases in ICD-11 classification [BR:br08403]
 05 Endocrine, nutritional or metabolic diseases
  Nutritional disorders
   Undernutrition
    5B5C  Vitamin B3 deficiency
     H01582  Pellagra
BRITE hierarchy
Other DBs
ICD-11: 5B5C.0
ICD-10: E52
MeSH: D010383
Reference
  Authors
Hegyi J, Schwartz RA, Hegyi V
  Title
Pellagra: dermatitis, dementia, and diarrhea.
  Journal
Int J Dermatol 43:1-5 (2004)
DOI:10.1111/j.1365-4632.2004.01959.x
Reference
  Authors
Badawy AA
  Title
Pellagra and alcoholism: a biochemical perspective.
  Journal
Alcohol Alcohol 49:238-50 (2014)
DOI:10.1093/alcalc/agu010
Reference
PMID:19892133 (drug)
  Authors
Lanska DJ
  Title
Chapter 30: historical aspects of the major neurological vitamin deficiency disorders: the water-soluble B vitamins.
  Journal
Handb Clin Neurol 95:445-76 (2010)
DOI:10.1016/S0072-9752(08)02130-1
Reference
PMID:16745723 (drug)
  Authors
Harris LJ
  Title
Flavin and the pellagra-preventing factor as separate constituents of a complex vitamin B(2).
  Journal
Biochem J 29:776-81 (1935)
DOI:10.1042/bj0290776

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