Distal renal tubular acidosis (RTA type 1) [DS:H00428] Proximal renal tubular acidosis (RTA type 2) [DS:H00429] Combined proximal and distal renal tubular acidosis [DS:H00241] Hyperkalemic distal renal tubular acidosis (RTA type 4) [DS:H00243]
Description
Renal tubular acidosis (RTA) is characterized by metabolic acidosis, a severe disturbance of extracellular pH homeostasis, due to renal impaired acid excretion. RTA can be subcategorized into different disorders. Distal RTA (type 1) arises when the collecting duct fails to remove excess acid into the urine. Proximal RTA (type 2) is caused by an impairment of bicarbonate reabsorption in the proximal tubules. RTA type 3 is a mixed type that shares the features of both proximal and distal lesions. RTA type 4 is a heterogeneous group of disorders associated with hyperkalemia due to aldosterone deficiency or impairment in aldosterone molecular signaling.
Category
Urinary system disease
Brite
Human diseases in ICD-11 classification [BR:br08403]
16 Diseases of the genitourinary system
Diseases of the urinary system
GB90 Certain specified disorders of kidney or ureter
H02310 Renal tubular acidosis