KEGG   Equus asinus (ass): 106845083Help
Entry
106845083         CDS       T04645                                 

Gene name
IDE
Definition
(RefSeq) insulin degrading enzyme
  KO
K01408  insulysin [EC:3.4.24.56]
Organism
eai  Equus asinus (ass)
Pathway
eai05010  Alzheimer disease
Brite
KEGG Orthology (KO) [BR:eai00001]
 09160 Human Diseases
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    106845083 (IDE)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:eai01002]
    106845083 (IDE)
Enzymes [BR:eai01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.24  Metalloendopeptidases
    3.4.24.56  insulysin
     106845083 (IDE)
Peptidases and inhibitors [BR:eai01002]
 Metallo peptidases
  Family M16: pitrilysin family
   106845083 (IDE)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: Peptidase_M16_M Peptidase_M16 Peptidase_M16_C Tn916-Xis
Motif
Other DBs
NCBI-GeneID: 106845083
NCBI-ProteinID: XP_014718426
Position
Un
AA seq 1019 aa AA seqDB search
MRYRLAWLLHPALPSTFRSVLGARLPPPERLSGFQKKTYSKMNNPAIKRLGNHIIKSPED
KREYRGLQLANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHMLFLGTKK
YPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKD
REVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQE
LLKFHSTYYSSNLMAICVLGRESLDDLTDLVVKLFSEVENKNVPLPEFPEHPFQEEHLKQ
LYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLV
GGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAV
AFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAV
VSKSFEGKTDCTEEWYGTQYRQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEILSL
EKEATPYPSLIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELL
KDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFE
IIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLL
SRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQ
QRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRA
NGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKL
SAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLA
REMDSCPVVGEFPCQNDINLSQAPGLPQPEVIQNMTEFKRGLPLFPLVKPHINFMAAKL
NT seq 3060 nt NT seq  +upstreamnt  +downstreamnt
atgcggtaccggctagcgtggctgttgcacccggcgctgcccagcacctttcgctcggtc
ctcggcgcccgcctgccgcctccagagcgcctctctggtttccaaaaaaagacttacagc
aaaatgaataatccagctatcaagagactaggaaatcatattatcaaatctcctgaagat
aagcgagaatatcgtgggctacaactggccaatggtatcaaagtacttctcatcagcgat
cccaccacggataaatcatcggcagcccttgatgtccacataggttcattgtcagatcct
ccaaatatcgctggcttaagtcatttttgtgaacatatgctatttttgggaacaaagaaa
taccctaaagaaaatgaatacagccagtttctcagtgagcatgcaggaagttcaaatgcc
tttactagtggagagcataccaattactatttcgatgtttcccatgaacacctagaaggt
gccctagacaggtttgcacaatttttcctgtgccccttgtttgatgagagttgcaaagac
agagaggtgaatgcagttgattcagaacatgagaagaatgtgatgaatgatgcttggaga
ctctttcagctggaaaaagctaccgggaatcccaaacacccgttcagcaaatttgggaca
ggtaacaaatatactctagagaccagaccaaaccaagaaggcattgatgtaagacaagag
ctattgaaattccattctacttattattcatccaacttaatggctatttgtgttttaggt
cgagaatctttagacgacctgactgatctggtggtaaagttattttctgaagtagagaac
aaaaatgtcccattgccagaatttcctgaacaccctttccaagaagaacatcttaaacaa
ctttacaaaatagtacccattaaggatattaggaatctttatgtgacatttcccatacct
gaccttcagaaatactacaaatcaaatcctggtcattatcttggtcatctcattgggcac
gaaggtcctgggagtctgttatcagaacttaaatcaaagggctgggtaaatactcttgtt
ggtggacagaaggaaggagcccgaggttttatgttttttatcattaatgtggacttgact
gaggaaggattattacacgttgaagatataattttgcacatgtttcaatacattcagaag
ttacgtgcagaaggacctcaagaatgggttttccaagagtgcaaggacttgaatgctgtc
gcttttaggtttaaagataaagagaggccaaggggctatacttctaagattgcaggaata
ttgcattattatcccctagaagaagtcctcacagctgagtatttactggaagaatttaga
cccgatttaatagagatggttctcgataaactcagaccagaaaatgtccgggttgcagta
gtttccaaatcttttgagggaaaaacggattgcacggaagagtggtatggaacccagtac
agacaagaagctataccagatgaggtcattaagaaatggcaaaatgctgacctgaatggg
aaatttaaacttccaacaaagaatgaatttatccctacgaattttgagattttatcatta
gaaaaagaagcgacaccatacccttctcttattaaggatacagctatgagcaaactctgg
ttcaaacaagatgataagtttttcttaccgaaggcttgtctcaactttgaatttttcagc
ccatttgcttatgtggaccccttgcactgtaacatggcctatttgtaccttgagctcctc
aaagactcactcaacgagtatgcatatgcagcagagctagcaggcttgagctatgacctc
caaaataccatctatgggatgtatctctcagtgaaaggttacaatgacaagcagccaatt
ttgctaaagaagattattgagaaaatggctacctttgagattgatgaaaaaagatttgaa
attatcaaagaggcatatatgcgatctctgaacaatttccgagctgagcagcctcaccag
catgccatgtactacctccgcttgctgatgactgaagtggcctggacgaaagatgaatta
aaggaagccctggatgatgtcacccttcctcgccttaaggccttcatacctcagctcctg
tcacggctgcacattgaagcccttctccatggaaacataacaaagcaggctgcattagga
attatgcagatggttgaagatactcttattgaacatgctcatacgaaacctctccttcca
agtcagctcgttcggtatagagaagttcagctccctgacagaggatggtttgtttaccag
cagaggaatgaagttcacaataactgtggcatcgagatctactaccaaacagacatgcag
agcacctcggagaatatgtttctagagctcttctgtcagatcatctcagagccttgcttc
aacactctgcgcaccaaggagcagctgggctatattgtcttcagcgggccacggcgagcc
aacggcatccagggtttacggtttattatccagtcagaaaagccgcctcactacctggaa
agccgagtggaagctttcttaatcaccatggaaaagtccatagaggacatgacagaagag
gccttccagaaacacattcaggcgttagcgattcgtcgactagacaaaccaaagaaactc
tctgcagagtgtgctaaatattggggggaaatcatctcccagcaatacaatttcgacaga
gataatacagaagttgcatatttaaagacacttaccaaggaagatatcatcaagttctat
aaggaaatgttggcagtagatgccccaaggagacataaggtatccgtccatgttcttgcg
agagaaatggattcttgtcctgtggttggagagttcccatgtcagaatgatattaatttg
tcacaagcaccaggcttgccacaacctgaagtgattcagaacatgaccgagttcaagcgt
ggtttgccactgtttccccttgtgaaaccgcacattaacttcatggctgcaaagctctga

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