KEGG   Equus asinus (ass): 106848607
Entry
106848607         CDS       T04645                                 

Gene name
ADCY4
Definition
(RefSeq) adenylate cyclase 4
  KO
K08044  adenylate cyclase 4 [EC:4.6.1.1]
Organism
eai  Equus asinus (ass)
Pathway
eai00230  Purine metabolism
eai01100  Metabolic pathways
eai01522  Endocrine resistance
eai04015  Rap1 signaling pathway
eai04020  Calcium signaling pathway
eai04022  cGMP-PKG signaling pathway
eai04024  cAMP signaling pathway
eai04062  Chemokine signaling pathway
eai04072  Phospholipase D signaling pathway
eai04114  Oocyte meiosis
eai04211  Longevity regulating pathway
eai04213  Longevity regulating pathway - multiple species
eai04261  Adrenergic signaling in cardiomyocytes
eai04270  Vascular smooth muscle contraction
eai04371  Apelin signaling pathway
eai04540  Gap junction
eai04611  Platelet activation
eai04713  Circadian entrainment
eai04714  Thermogenesis
eai04723  Retrograde endocannabinoid signaling
eai04724  Glutamatergic synapse
eai04725  Cholinergic synapse
eai04727  GABAergic synapse
eai04742  Taste transduction
eai04750  Inflammatory mediator regulation of TRP channels
eai04911  Insulin secretion
eai04912  GnRH signaling pathway
eai04913  Ovarian steroidogenesis
eai04914  Progesterone-mediated oocyte maturation
eai04915  Estrogen signaling pathway
eai04916  Melanogenesis
eai04918  Thyroid hormone synthesis
eai04921  Oxytocin signaling pathway
eai04923  Regulation of lipolysis in adipocytes
eai04925  Aldosterone synthesis and secretion
eai04926  Relaxin signaling pathway
eai04927  Cortisol synthesis and secretion
eai04928  Parathyroid hormone synthesis, secretion and action
eai04934  Cushing syndrome
eai04935  Growth hormone synthesis, secretion and action
eai04970  Salivary secretion
eai04971  Gastric acid secretion
eai04972  Pancreatic secretion
eai04976  Bile secretion
eai05032  Morphine addiction
eai05163  Human cytomegalovirus infection
eai05166  Human T-cell leukemia virus 1 infection
eai05200  Pathways in cancer
eai05414  Dilated cardiomyopathy (DCM)
Brite
KEGG Orthology (KO) [BR:eai00001]
 09100 Metabolism
  09104 Nucleotide metabolism
   00230 Purine metabolism
    106848607 (ADCY4)
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    106848607 (ADCY4)
   04371 Apelin signaling pathway
    106848607 (ADCY4)
   04020 Calcium signaling pathway
    106848607 (ADCY4)
   04072 Phospholipase D signaling pathway
    106848607 (ADCY4)
   04024 cAMP signaling pathway
    106848607 (ADCY4)
   04022 cGMP-PKG signaling pathway
    106848607 (ADCY4)
 09140 Cellular Processes
  09143 Cell growth and death
   04114 Oocyte meiosis
    106848607 (ADCY4)
  09144 Cellular community - eukaryotes
   04540 Gap junction
    106848607 (ADCY4)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    106848607 (ADCY4)
   04062 Chemokine signaling pathway
    106848607 (ADCY4)
  09152 Endocrine system
   04911 Insulin secretion
    106848607 (ADCY4)
   04923 Regulation of lipolysis in adipocytes
    106848607 (ADCY4)
   04912 GnRH signaling pathway
    106848607 (ADCY4)
   04913 Ovarian steroidogenesis
    106848607 (ADCY4)
   04915 Estrogen signaling pathway
    106848607 (ADCY4)
   04914 Progesterone-mediated oocyte maturation
    106848607 (ADCY4)
   04921 Oxytocin signaling pathway
    106848607 (ADCY4)
   04926 Relaxin signaling pathway
    106848607 (ADCY4)
   04935 Growth hormone synthesis, secretion and action
    106848607 (ADCY4)
   04918 Thyroid hormone synthesis
    106848607 (ADCY4)
   04928 Parathyroid hormone synthesis, secretion and action
    106848607 (ADCY4)
   04916 Melanogenesis
    106848607 (ADCY4)
   04925 Aldosterone synthesis and secretion
    106848607 (ADCY4)
   04927 Cortisol synthesis and secretion
    106848607 (ADCY4)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    106848607 (ADCY4)
   04270 Vascular smooth muscle contraction
    106848607 (ADCY4)
  09154 Digestive system
   04970 Salivary secretion
    106848607 (ADCY4)
   04971 Gastric acid secretion
    106848607 (ADCY4)
   04972 Pancreatic secretion
    106848607 (ADCY4)
   04976 Bile secretion
    106848607 (ADCY4)
  09156 Nervous system
   04724 Glutamatergic synapse
    106848607 (ADCY4)
   04727 GABAergic synapse
    106848607 (ADCY4)
   04725 Cholinergic synapse
    106848607 (ADCY4)
   04723 Retrograde endocannabinoid signaling
    106848607 (ADCY4)
  09157 Sensory system
   04742 Taste transduction
    106848607 (ADCY4)
   04750 Inflammatory mediator regulation of TRP channels
    106848607 (ADCY4)
  09149 Aging
   04211 Longevity regulating pathway
    106848607 (ADCY4)
   04213 Longevity regulating pathway - multiple species
    106848607 (ADCY4)
  09159 Environmental adaptation
   04713 Circadian entrainment
    106848607 (ADCY4)
   04714 Thermogenesis
    106848607 (ADCY4)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    106848607 (ADCY4)
  09165 Substance dependence
   05032 Morphine addiction
    106848607 (ADCY4)
  09166 Cardiovascular disease
   05414 Dilated cardiomyopathy (DCM)
    106848607 (ADCY4)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    106848607 (ADCY4)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    106848607 (ADCY4)
   05163 Human cytomegalovirus infection
    106848607 (ADCY4)
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    106848607 (ADCY4)
Enzymes [BR:eai01000]
 4. Lyases
  4.6  Phosphorus-oxygen lyases
   4.6.1  Phosphorus-oxygen lyases (only sub-subclass identified to date)
    4.6.1.1  adenylate cyclase
     106848607 (ADCY4)
SSDB
Motif
Pfam: Guanylate_cyc DUF1053 AC_N
Other DBs
NCBI-GeneID: 106848607
NCBI-ProteinID: XP_014724099
Position
Un
AA seq 1077 aa
MARLFSPRPPPSEDLFYETYYSLSQQYPLLLMLLAIVLCALLALLAVAWASGRELASDTG
FLTTVLCALGGFSLLLGLASREHRLQRWTRPLSGLVWAALLALGYSFLFTGGVVSAWDQV
SFFLFVIFTVYAMLPLGMRDATAAGLASSLSHLLVLGLYLGPQPDSRPALLPQLAANAVL
FLCGNVAGAYHKALMERALRATFREALSSLHSRRRLDTEKKHQEHLLLSILPAYLAQEMK
AEIMARLQAGQGSRPESTNNFHSLYVKRHQGVSVLYADIVGFTRLASECSPKELVLMLNE
LFGKFDQIAKEHECMRIKILGDCYYCVSGLPLSLPDHAINCVRMGLDMCRAIRKLRAATG
VDINMRVGVHSGSVLCGVIGLQKWQYDVWSHDVTLANHMEAGGVPGRVHITGATLALLAG
AYAVEDAAMEHRDPYLRELGEPTYLVIDPRAEEEDEKGTAGGLLSSLEGPKMRPSLLMTR
YLESWGAAKPFAHLSHVESPVSTSTPLPEKALASFSPQWSLDRSRTPRGLDEELDTGDAK
FFQVIEQLNSQKQWKQSKDFNPLTLYFREKEMEKEYRLSALPAFKYYTACTFLVSVSIFI
VQMLVTNRPPALAITYSITFLLFLLLLFICFSEHLTRCVLKGPKVLHWLPALSGLVSTRP
GLRVALGTATILLVFAMAITSLFFLPPASKCPFQAPNVSSMALNLSWELPGSLPLISIPY
SMHCCVLGFLSCSLFLHMSFELKLLLLLLWLTASCSLFLHSHAWLSDCLIARLYLGPADS
RPGVLKEPKMMGAISFFIFFFTLLVLARQNEYYCRLDFLWKKKLRQEREETETMENLTRL
LLENVLPAHVAPQFIGQNRRNEDLYHQSYECVCVLFASVPDFKEFYSESNINHEGLECLR
LLNEIIADFDELLSKPKFSGVEKIKTIGSTYMAATGLNATSGQDAQQDAERSCSHLGTMV
EFAVALGSKLDVINKHSFNNFRLRVGLNHGPVVAGVIGAQKPQYDIWGNTVNVASRMEST
GVLGKIQVTEETARALQSLGYTCYSRGVIKVKGKGQLCTYFLNTDLTRTGPPSAALG
NT seq 3234 nt   +upstreamnt  +downstreamnt
atggcccgcctcttcagtccccggccgccgcccagcgaagacctcttctacgagacctac
tacagcctgagccagcagtacccactgctgctaatgctgctggccatcgtgctctgcgcg
ctcctggcgctgctcgcggtcgcctgggccagtggcagggagctggcctctgacacgggc
ttcctgaccactgtgctgtgcgcgttgggcggcttctcgttgctgctgggcttggcttcc
cgcgagcaccgactgcagcgctggacgcgtcccctgtccggcctcgtgtgggcagcgctg
cttgcgctaggctacagcttcctgttcaccgggggcgtggtgagcgcctgggaccaggta
tcctttttcctctttgtcatcttcacggtctatgccatgctgcccttgggcatgcgggac
gccaccgccgcgggcctcgcctcctcactctcacacctgctggttcttgggctgtatctt
gggcctcaacccgactctaggcccgcgctgctgcctcagctggcagcaaacgcggtattg
ttcctgtgcgggaacgtggctggagcgtaccacaaggcgctgatggagcgcgccctgcgc
gccacgttccgggaggcgctgagttccctgcactcgcgccggcggctggacaccgagaag
aagcaccaggaacaccttctcttgtccatccttcctgcctacttggcccaagagatgaag
gcagagatcatggcacggctgcaggctggacaggggtcacggccagagagcaccaacaac
ttccatagcctctatgtcaagaggcaccagggagtcagcgtgctgtatgctgacatcgtg
ggcttcacgaggctggccagtgagtgctcccctaaagagttggtgctcatgctcaacgag
ctctttggcaagttcgaccagatcgccaaggagcatgaatgcatgcggatcaagatcctg
ggagactgttactactgtgtctccgggctgccactctcgctgccagaccacgccatcaac
tgcgtgcgcatggggctggacatgtgccgggccatcaggaaacttcgggcagccactggt
gtggacatcaacatgcgtgtgggtgtgcactcaggcagcgtgctctgcggagtcatcggc
ctgcagaagtggcagtacgatgtctggtcgcatgacgtcacactggccaaccacatggag
gccggtggcgtgccagggcgtgtacatatcacaggggctaccctggccctgctggcaggg
gcttatgctgtggaggatgcagccatggaacaccgagacccgtaccttcgggagctaggg
gagcctacctacctggtcatcgatccccgggctgaggaagaggacgagaagggcactgca
ggagggttgctgtcctctcttgagggccccaagatgcgtccatcactgctgatgacccgc
tacctggagtcctggggtgcagccaagccttttgcccacctgagccacgtagagagccct
gtgtccacctccactcctctcccagagaaggccctggcttccttcagcccccagtggagc
ctggaccggagccgtaccccccggggactagatgaggaattggacaccggggatgccaag
ttcttccaggtcattgaacagctcaactctcagaaacagtggaagcagtcgaaggacttc
aacccactgacactgtacttccgagagaaggagatggagaaagagtatcgactctctgca
ctccccgccttcaaatactacacagcctgcaccttcctggtttctgtctccatcttcatc
gtccagatgctggtgacaaacaggcccccagctctggccatcacctatagtatcaccttc
ctcctcttcctcctcctcctcttcatctgtttctcagagcacctgacgaggtgtgtcttg
aaaggccccaaggtgctacactggctgcctgcactgtctggcctggtgtccacacggccc
ggactgcgagtcgccctgggcaccgccaccatccttctcgtcttcgccatggccattacc
agcctgttcttcttaccgccagcatcgaagtgccctttccaggctcccaatgtgtcctcc
atggctttgaacctctcctgggagctccctgggtccctgcctctcatcagcatcccatac
tccatgcactgctgtgtgctgggtttcctctcctgctccctctttctgcacatgagcttc
gaactgaagctgctgctgctcctgctgtggctgacggcctcctgctccctcttcttgcac
tcccacgcctggctgtctgactgcctcatcgcccgcctctatctgggccccgcggattcc
aggccaggggtgctgaaggagcccaaaatgatgggcgctatctccttcttcatcttcttc
tttaccctccttgtcctggctcggcagaatgaatattactgccgcctggacttcctgtgg
aagaagaagctgaggcaggagcgggaggagacagagacaatggagaacctgacccggctg
ctcttggagaatgtgctccctgcgcacgtggccccccagttcattggccagaaccggcgc
aacgaggatctctaccaccagtcgtacgagtgtgtttgtgtcctcttcgcctccgtccca
gacttcaaggagttttactctgaatccaatatcaaccacgagggcctagagtgtctgcgg
ctgctcaatgagataattgctgattttgatgagctgctctccaagcccaaattcagtggc
gtggagaagatcaaaaccattggcagcacctacatggcagctacaggcttaaatgccacc
tctggacaggacgcacagcaggatgctgagcgaagttgcagccaccttggcaccatggtg
gaattcgcagtggccctcgggtctaagctagatgtcatcaacaagcactcattcaacaac
ttccgcttgcgtgtggggttgaaccacggaccagtagtggctggagtgattggggcccag
aagccacaatacgacatctggggcaacacggtgaacgtggccagccgcatggagagtaca
ggagtcctgggcaagatccaagtgactgaagagacagctcgggcgctgcagtctttaggc
tacacctgctacagccggggtgtcatcaaggtcaaaggcaaagggcagctctgcacctac
ttcctgaacacagatttgacacgaactggacctccctcggccgccctgggctga

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