KEGG   ENZYME: 1.1.1.130
Entry
EC 1.1.1.130                Enzyme                                 
Name
3-dehydro-L-gulonate 2-dehydrogenase;
3-keto-L-gulonate dehydrogenase;
3-ketogulonate dehydrogenase;
3-keto-L-gulonate dehydrogenase;
3-ketogulonate dehydrogenase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
3-dehydro-L-gulonate:NAD(P)+ 2-oxidoreductase
Reaction(IUBMB)
3-dehydro-L-gulonate + NAD(P)+ = (4R,5S)-4,5,6-trihydroxy-2,3-dioxohexanoate + NAD(P)H + H+ [RN:R02637 R02639]
Reaction(KEGG)
R02637 R02639
Substrate
3-dehydro-L-gulonate [CPD:C00618];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006]
Product
(4R,5S)-4,5,6-trihydroxy-2,3-dioxohexanoate [CPD:C04575];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080]
History
EC 1.1.1.130 created 1972
Pathway
ec00040  Pentose and glucuronate interconversions
ec00053  Ascorbate and aldarate metabolism
ec01100  Metabolic pathways
Orthology
K08092  3-dehydro-L-gulonate 2-dehydrogenase
Genes
ECOb3575(yiaK)
ECJJW3547(yiaK)
ECDECDH10B_3756(yiaK)
EBWBWG_3265(yiaK)
ECOKECMDS42_3012(yiaK)
ECOCC3026_19385
EOIECO111_4395(yiaK)
EOJECO26_5026(yiaK)
EOHECO103_4659(yiaK)
ESLO3K_00975
ESOO3O_24700
ESMO3M_01005
ECKEC55989_4032(yiaK)
ECGE2348C_3827(yiaK)
ELHETEC_3818
ECWEcE24377A_4072(dlgD)
EUNUMNK88_4360
ECPECP_3679
ENAECNA114_3727(yiaK)
ECOSEC958_3982(yiaK)
ECVAPECO1_2875(yiaK)
ECOAAPECO78_21690
ECXEcHS_A3779(dlgD)
ECMEcSMS35_3898(dlgD)
ECYECSE_3851
ECRECIAI1_3742(yiaK)
ECQECED1_4263(yiaK)
EUMECUMN_4088(yiaK)
ECTECIAI39_4087(yiaK)
EOCCE10_4129(yiaK)
EBRECB_03427(yiaK)
ECOBC3029_21970
EBLECD_03427(yiaK)
EBEB21_03378(yiaK)
EBDECBD_0159
ECIUTI89_C4117(yiaK)
EIHECOK1_4022(dlgD)
ECZECS88_3994(yiaK)
ECCc4396(yiaK)
ELOEC042_3881(dlgD)
ELNNRG857_17800
ESEECSF_3410
ECLEcolC_0139
EKOEKO11_0151
EKFKO11_04845(yiaK)
EABECABU_c40180(dlgD)
EDHEcDH1_0135
EDJECDH1ME8569_3456(yiaK)
ELUUM146_18045
ELWECW_m3849(yiaK)
ELLWFL_18795(yiaK)
ELCi14_4063(yiaK)
ELDi02_4063(yiaK)
ELPP12B_c3704(yiaK)
ELFLF82_3339(yiaK)
ECOLLY180_18385
ECOIECOPMV1_03913(dlgD)
ECOJP423_19890
EFEEFER_3573(yiaK)
EALEAKF1_ch2371c
EMAC1192_15920
ESZFEM44_09065
ERUYOSH18_12085(yiaK)
STYSTY4130
STTt3851
SEXSTBHUCCB_40640
SENTTY21A_19565
STMSTM3668(yiaK)
SEOSTM14_4425(yiaK)
SEVSTMMW_36561
SEYSL1344_3633(yiaK)
SEMSTMDT12_C37250
SEJSTMUK_3654(yiaK)
SEBSTM474_3840(yiaK)
SEFUMN798_3985
SETUSTU288_18530
SETCCFSAN001921_22105
SENRSTMDT2_35521
SENDDT104_36511
SENICY43_19040
SEENSE451236_02580
SPTSPA3519(yiaK)
SEKSSPA3286
SPQSPAB_04559
SEISPC_3748(yiaK)
SEHSeHA_C3991
SHBSU5_04145
SENHCFSAN002069_13700
SEEHSEEH1578_04425
SEESNSL254_A3946
SENNSN31241_2150
SEWSeSA_A3866
SEASeAg_B3882
SENSQ786_17920
SEDSeD_A4053
SEGSG3763(yiaK)
SELSPUL_3897(yiaK)
SEGASPUCDC_3883(yiaK)
SETSEN3490(yiaK)
SENAAU38_17830
SENOAU37_18020
SENVAU39_18025
SENQAU40_20080
SENLIY59_18465
SENJCFSAN001992_15305
SEECCFSAN002050_25310
SEEBSEEB0189_001535
SEEPI137_18700
SENBBN855_37560
SENEIA1_17815
SENCSEET0819_02100
SALZEOS98_00910
SFLSF3619(yiaK)
SFXS4150(yiaK)
SFVSFV_3965(yiaK)
SFESFxv_3943(yiaK)
SFNSFy_5156
SFSSFyv_5232
SFTNCTC1_03914(yiaK)
SBOSBO_3583(yiaK)
SBCSbBS512_E3947(dlgD)
SHQA0259_21705
ENCECL_00191
ENLA3UG_00985
ECLGEC036_01840
ECLEECNIH2_22595
ECLIECNIH5_21115
ECLXLI66_21885
ECLYLI62_23905
ECLOENC_47440
EHMAB284_02935
EXFBFV63_21225
ECLAECNIH3_21195
ECLCECR091_21125
EECEcWSU1_00160(dlgD)
ELGBH714_15955
ECANCWI88_00910
ERNBFV67_00725
ECLSLI67_001705
ECHGFY206_00880
ESHC1N69_00775
EASEntas_0167
ENFAKI40_2078(yiaK)
LNICWR52_11755
EBGFAI37_05810
ENSHWQ15_07205(yiaK)
ENKLOC22_09765(yiaK)
EHUD5067_0022360
EMORL6Y89_21365(yiaK)
EQUOM418_00745(yiaK)
EPUQVH39_00765(yiaK)
KPEKPK_0166(dlgD)
KVDKR75_07255
KOXKOX_05675
KOEA225_5605
KOYJ415_04080
KOMHR38_04170
KOKKONIH1_28205
KOCAB185_08195
KQVB8P98_00955
KLLBJF97_27840
KLWDA718_01050
KARLGL98_00900(yiaK)
KGRJJJ10_00975(yiaK)
KPASLUW96_05610(yiaK)
KLCK7H21_00915(yiaK)
KLMBWI76_27080
REEelectrica_00162(dlgD)
RORRORB6_19620
RONTE10_01345
RAODSD31_00925
CKOCKO_05033
CFDCFNIH1_05490
CBRAA6J81_18070
CWECO701_22940
CFQC2U38_26735
CIFAL515_00420
CIEAN232_05315
CPARCUC49_18435
CITZE4Z61_17830
CARSE1B03_25335
CIXM4I31_00840(yiaK)
ESCEntcl_0163
KLEAO703_20620
KORAWR26_18130(yiaK)
KRDA3780_06125
KOOO9K67_17730(yiaK)
KOUC0557_06555
KASKATP_01750(dlgD_1) KATP_21200(dlgD_2)
LAZA8A57_00930
LEFLJPFL01_0151
LEWDAI21_03610
BFTMNO13_13410(yiaK)
BSELRHD99_07420(yiaK)
KINAB182_26300
PDZHHA33_03015(yiaK)
METYMRY16398_01670(dlgD)
IZHFEM41_13790
PSGCG163CM_37550(dlgD)
SUPEP0H77_01115(yiaK) P0H77_19615(yiaK)
EBFD782_0150
EBCC2U52_09105
EBBF652_2161 F652_2795
YINCH53_4238(dlgD)
YMADA391_10455
SMACSMDB11_3331(dlgD)
SPESpro_3933
SRRSerAS9_4139
SRLSOD_c38930(dlgD)
SRYM621_20900
SPLYQ5A_020880(dlgD)
SRSSerAS12_4140
SRASerAS13_4140
SLQM495_20535
SFWWN53_21580
SFGAV650_17370
SQUE4343_20725
SNEMNLX84_20500(yiaK)
SGRISGBXF1_04033(dlgD)
SFOZ042_06785
RAHRahaq_1074
RACEJHW33_22085(yiaK)
RAQRahaq2_1145
RAAQ7S_05145
ROXBV494_00640 BV494_15210
RBONQNM34_05475(yiaK)
SERASer39006_020885 Ser39006_022675
SERQCWC46_20890 CWC46_22685
PCTPC1_3692
PWAPecwa_3889
PPARA8F97_22060
PECW5S_4035
PWSA7983_04500 A7983_12495 A7983_12510
PPUJE2566_18665
PARII2D83_03340(yiaK)
PAQUDMB82_0017635(yiaK)
PQUIG609_017415(yiaK)
PPOOLW347_18720(yiaK)
PACBM9782_06655(yiaK)
BGJAWC36_17715
PRODPCO85_02485(yiaK) PCO85_04565(yiaK)
SODSant_1948
EPECI789_16640
ETPLU633_19545(yiaK)
ERPLJN55_21155(yiaK)
PAMPANA_0364(dlgD)
PLFPANA5342_4050(dlgD)
PAJPAJ_3520(dlgD)
PAQPAGR_g3913
PAOPat9b_1877
PSTWDSJ_03410
PPHOCTZ24_09875
TCIA7K98_02595
EHOA9798_02100
HAVAT03_19190
HPARAL518_07400 AL518_10545
OPODSM2777_06205
HINHI_1031
HIQCGSHiGG_08775
HPAKJT17_07790
HSOHS_0759(mdh)
HSMHSM_1226
PMUPM1256
PMVPMCN06_1920(dlgD)
PULNT08PM_2210
PMPPmu_19160(dlgD)
PMULDR93_499(dlgD)
PDAG4362423_01625(dlgD)
PSKYA6B44_10495
PATLKGI96_10570(yiaK)
PCAIK7G93_001845(yiaK)
MSUMS0054
BSUNA4G13_09070
MHTD648_390
MHQD650_370
MHATB824_1140
MHXMHH_c05720(dlgD)
MHAEF382_07945
MHAMJ450_07145
MHAOJ451_08025
MHALN220_00120
MHAQWC39_00180
MHAYVK67_00185
MVRX781_670
MVIX808_820
MVGX874_790
MVEX875_20260
MGRAA4G16_09800
MBOSICJ55_02005(yiaK)
MPEGHV560_02710(yiaK)
MANNGM695_02540
APLAPL_1573
APJAPJL_1604 APJL_1605
APAAPP7_1635
ASUAsuc_0268
ASIASU2_10040
ASSASU1_10085
AEUACEE_10335
APORDDU33_01580
ALIGNCTC10568_01932(dlgD)
AGPNYR63_08455(yiaK)
AGKNYR60_07035(yiaK)
GSSNYR30_10705(yiaK)
BTOWQG_22320
BTREF542_290
BTRHF543_300
BTRAF544_22850
RPNENCTC8284_03314(dlgD_2)
RHEYFEE42_11320
RHAEIHV77_10320(yiaK)
OOIA6A10_00695 A6A10_00745
FCLA4G17_03000
BHUDA6A11_09075
PAETNCTC13378_00072(dlgD)
VSPVS_II0146
VGABSQ33_11610
VSHBSZ05_18275
VSRVspart_00567(dlgD)
VLEISX51_21815(yiaK)
VRURND59_03335(yiaK)
MKEOOT55_06440(yiaK)
HHUAR456_18335
HPROLMS44_04965(yiaK)
HBHE4T21_20090(yiaK)
HALFQEN58_04320(yiaK)
HOLHORIV_15110(dlgD)
HNPSR894_04265(yiaK)
HTTHZS52_23275(yiaK)
HAAA5892_03140
KUSB9G99_15925
KMAB9H00_15710
MARSA8C75_18935
BCTGEM_3243
BPYRABD05_23400
BANNJFN94_16455(yiaK)
BURKDM992_23800
PTSCUJ90_31490
MARUFIU81_09120(dlgD)
PZHCX676_12965
PAROCUV01_08870
OCNCUC15_16400
NCMQNK12_13515(yiaK)
SPAEE2C16_10285
CBEILF65_03926
CPASClopa_1614
CPATCLPA_c27020(dlgD)
CPAECPAST_c27020(dlgD)
CEUA7L45_01920
ALKAJ0B03_03745(yiaK) J0B03_03860(yiaK)
BLIQINP51_13510(yiaK)
CPYCphy_1597
LACYA4V08_05145 A4V08_19720 A4V08_26375
LXAOW255_01530(yiaK)
RGNRGna_04580
CBOLCGC65_17835 CGC65_28090
CASPNQ535_05220(yiaK) NQ535_09435(yiaK) NQ535_23280(yiaK)
DFMNQ560_12490(yiaK)
QDOH9Q78_10435(yiaK)
MFORNQ534_12200(yiaK)
CBARPATL70BA_2571(yiaK)
GFEGferi_07860
HALSD7D81_01315
IFNGM661_17375
APRApre_0576
MHAPJFY71_00655(yiaK)
PUFUFO1_3871
ERBA4V01_00980
APALBN85403770
GEZFE251_05235
SLOMPXH66_21015(yiaK)
TPAVHRQ91_07735(yiaK)
SBUSpiBuddy_2240
SGPSpiGrapes_1800 SpiGrapes_2576
SASSMUG09_12345(yiaK) MUG09_13745(yiaK)
ACAACP_1954
ACMAciX9_1752
GMAAciX8_0342
GRBGOB94_08635
TSAAciPR4_0567
TALBFTW19_15705
EDAGWR55_06525(yiaK)
EDGH7846_13235(yiaK)
ORPMOP44_12565(yiaK)
PFERIRI77_25355(yiaK)
GBAJ421_0713
DRCG0Q07_19910(yiaK)
MCOSGM418_15300
ANFAQPE_3768
CHFKTO58_24915(yiaK)
CSACSIO70_18050(yiaK)
NKONiako_3650
FGGFSB75_04805
HHYHalhy_6468
PHEPhep_3438
PGSCPT03_01000
PEJFYC62_04300
PSNPedsa_2698
MUPA0256_23975
MUCMuYL_3799
MGOTMgSA37_04096(dlgD)
MUHHYN43_028665
MGINFRZ54_22780
MGKFSB76_05645
MRUBDEO27_030395
MGOSDIU38_032655
MMABHQ865_17775(yiaK)
MDJLLH06_05880(yiaK)
MJJPQO05_04185(yiaK)
MSABSNE25_06615(yiaK)
CMRCycma_3367
CAMUCA2015_3203
EVIEchvi_3091
ESTDN752_22295
ECHIFKX85_14620
EMAIKZP23_19675(yiaK)
RHOZGXP67_33145(yiaK)
PSEZHME7025_02598(dpkA)
EOLEmtol_1032
RSIRunsl_5467
RUPDTQ70_01990
FIBA6C57_03190
HYZAXW84_03380
HYJFHG12_13530
PKOPKOR_07140
PACTCA264_18075
PONTC1N53_18440
RUFTH63_05215
CLITOQ292_23085(yiaK)
IRORT717_14585(yiaK)
FBTD770_00610
CHKD4L85_18090
MARMYQ22_10005
MARTBTR34_10075
MAREEJ994_10305
SEONBWZ22_15620
AALGAREALGSMS7_03762(dlgD)
MARFCJ739_2488
EMARD1013_18825
ASAGFGM00_11440
RBARAWN76_004040
MROMROS_2339
 » show all
Reference
1  [PMID:13926592]
  Authors
VOLK WA, LARSEN JL.
  Title
beta-Keto-L-gulonic acid as an intermediate in the bacterial metabolism of ascorbic acid.
  Journal
J Biol Chem 237:2454-7 (1962)
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.130
IUBMB Enzyme Nomenclature: 1.1.1.130
ExPASy - ENZYME nomenclature database: 1.1.1.130
BRENDA, the Enzyme Database: 1.1.1.130
CAS: 37250-61-6

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