KEGG   ENZYME: 1.1.1.132
Entry
EC 1.1.1.132                Enzyme                                 
Name
GDP-mannose 6-dehydrogenase;
guanosine diphosphomannose dehydrogenase;
GDP-mannose dehydrogenase;
guanosine diphosphomannose dehydrogenase;
guanosine diphospho-D-mannose dehydrogenase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
GDP-D-mannose:NAD+ 6-oxidoreductase
Reaction(IUBMB)
GDP-D-mannose + 2 NAD+ + H2O = GDP-D-mannuronate + 2 NADH + 2 H+ [RN:R00880]
Reaction(KEGG)
R00880
Substrate
GDP-D-mannose [CPD:C00096];
NAD+ [CPD:C00003];
H2O [CPD:C00001]
Product
GDP-D-mannuronate [CPD:C00976];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
Also acts on the corresponding deoxynucleoside diphosphate derivative as a substrate.
History
EC 1.1.1.132 created 1972
Pathway
ec00051  Fructose and mannose metabolism
ec00520  Amino sugar and nucleotide sugar metabolism
ec01100  Metabolic pathways
Orthology
K00066  GDP-mannose 6-dehydrogenase
Genes
LAREHIV01_005960
PAEPA3540(algD)
PAEVN297_3663(algD)
PAEIN296_3663(algD)
PAUPA14_18580(algD)
PAPPSPA7_1605(algD)
PAGPLES_14931(algD)
PAFPAM18_1446(algD)
PNCNCGM2_4665(algD)
PAEBNCGM1900_2744(algD)
PDKPADK2_06665
PSGG655_07100
PRPM062_18755
PAEPPA1S_07720
PAERPA1R_gp1358
PAEMU769_07195
PAELT223_07435
PAESSCV20265_1523
PAEUBN889_03910(algD)
PAEGAI22_26185
PAECM802_3660(algD)
PAEOM801_3528(algD)
SECHB18_00665
PMYPmen_1031 Pmen_1678
PMKMDS_1082
PREPCA10_11880(algD) PCA10_38230(algD)
PFUWKF707C_11170
PALCA0T30_11805
PCQPcP3B5_50680(algD)
PMUIG4G71_08975
PNTG5B91_26160
PPAAB7D75_07435
PPUPP_1288(algD)
PPFPput_4437
PPGPputGB1_4561
PPWPputW619_0889
PPTPPS_4403
PPBPPUBIRD1_4273
PPIYSA_03091
PPXT1E_3168(algD)
PPUHB479_22150
PPUTL483_27235
PPUNPP4_08000(algD)
PPUDDW66_4794
PFVPsefu_3880
PMONX969_21685
PMOTX970_21320
PPJRK21_00119
PMOLCLJ08_08380 CLJ08_22925
PALDLU682_024945
PIXRIN61_07120
PMOSO165_013045 O165_018560
PSTPSPTO_1243(algD)
PSBPsyr_1063
PSYRN018_20355
PSPPSPPH_1118(algD)
PSAVPSA3335_09095
PAMGBKM19_008085
PCIPCH70_10130
PAVLBKM03_07020
PVDCFBP1590__4277(algD)
PCABJGS08_19525
PCOFPOR16_18925
PTREI9H09_05090
PSYIMME58_05275
PASTN015_05985
PLIJKQP88_04855
PFLPFL_1024(algD)
PPRCPFLCHA0_c10440(algD)
PPROPPC_1062
PFEPSF113_4752
PFNHZ99_11915
PFOPfl01_0960(algD)
PFSPFLU_0990(algD)
PFCPflA506_0970(algD)
PPZH045_01690
PFBVO64_4071
PMANOU5_2447
PTVAA957_09045
PCGAXG94_09975
PVRPverR02_05230
PAZOAYR47_12230
POIBOP93_04735
PRXHRH33_05805
PMEDE3Z27_23120
PKRAYO71_07540
PMUDNCTC8068_04321(algD)
PTOLI7845_05045
PFWPF1751_v1c09480(algD)
PFFPFLUOLIPICF703390
PFXA7318_04290
PENPSEEN3453(algD-2) PSEEN4535(algD)
PBAPSEBR_a4590
PBCCD58_24305
PPUUPputUW4_04471(algD)
PDRH681_19425
PSVPVLB_04235 PVLB_15470
PSKU771_06125
PKCPKB_0968(algD)
PCHEY04_04520
PCZPCL1606_50710
PCPJM49_25125
PCHPC4K32_1103
PFZAV641_18510
PLQAA042_15150
PALKPSAKL28_08740 PSAKL28_31810
PPVNJ69_13830
PSESPSCI_0721
PSEMTO66_05210
PSECCCOS191_0912(algD1) CCOS191_2029(algD2)
PPSYAOC04_15730
PSOSPOS17_1030
PFKPFAS1_06330
PANRA7J50_0992
PSETTHL1_1268 THL1_3804
PSILPMA3_24585
PYMAK972_0838
PKEDLD99_05160
PALLUYA_04885 UYA_15320
PUMHGP31_04975
POJPtoMrB4_26000(algD) PtoMrB4_46190
PGGFX982_00687
PGYAWU82_19080 AWU82_29005
PLALFXN65_05555
PSEJHNQ25_10170 HNQ25_19280
PVKEPZ47_24330
PEZHWQ56_05050
PBZGN234_24015
PKHJLK41_05220(algD)
PTYJWV26_01370 JWV26_15965(algD)
PATAJWU58_22750
PDWBV82_3321 BV82_4690
PZEHU754_006270
PMOEHV782_005850
PCAMHNE05_07125
PSEPC4K39_1041
PPIIQL104_05175
PVWHU752_027430
PTRTHU722_0006165
PXAKSS93_07790
PSAMHU731_021005
PTZHU718_005910
PQIKH389_10480 KH389_22245
PSHHHU773_022835
PXNHU772_004420 HU772_009430
PHVHU739_012710
PPRGHU725_004085 HU725_014400
PANHHU763_020330
PASGKSS96_05695
PFAKKSS94_04615
PMUYKSS95_07475 KSS95_11760
PMAMKSS90_04835 KSS90_09905
PAZEKSS91_23845
PALVKSS97_06295
PORYEJA05_04800
PWZJ7655_04690(algD)
PTKEXN22_12380 EXN22_22955
PTWTUM18999_50120(algD)
PZAHU749_024140
PIEHU724_005670
PWYHU734_005480
PGFJ0G10_06075
PCAVD3880_05550 D3880_05610
PJUL1P09_20850
PHFNLY38_05240(algD) NLY38_16715
PIZLAB08_R50410
PPEGKUA23_05150
PSIINF676_05345
PSIHLOY51_04705
PCASLOY40_05230
PFITKJY40_05935
PASILG197_00315
PKMPZ739_23450
PNBNK667_22335
PSOAPSm6_09920(algD)
PTAIICN73_10950
PKKQQ992_23595
PKJQ1W70_05470 Q1W70_21865
PHYGJTY93_21615
PHOMKJF94_01550 KJF94_13595
PCHEQYM18_12805(algD) QYM18_23005(algD)
PCUCPSH97_04640
PTRLOU419_22545(algD)
PPAELDL65_16250
PPAOK3169_23650
PRHZCRX69_09220
PSJYAA098_05025
PSKUKUIN1_11040
PSHSJJN09_02540
PHEFPSH57_05225
AVNAvin_10970(algD)
AVLAvCA_10970(algD)
AVDAvCA6_10970(algD)
ACXAchr_31180(algD)
EAZJHT90_07865
ENTOMTZ49_11930
PDENF1C79_17950
PPHABVH74_05210
MSRAU15_13665
GAGGlaag_2800
PMESFX988_01104
PATPatl_1531
HMIsoil367_08790
ALKMNKI27_00790
CEGD0C16_11005
GILNHM04_15470
MEIYMIN45_P0136
THIMKFB96_07615
TFRIThiofri_03630(algD)
ABOABO_0384(algD)
ALNAS19_03970
GSNYC6258_00963
OMEOLMES_2098 OLMES_4477
TAUTola_1407
SVASVA_1550
REVHUE57_13005
PLGNCTC10937_04283(algD)
RFRRfer_0673
PAQAK9V56_012855 K9V56_012880
ATERMW290_14625
JAGGJA_3986(algD)
JALBZG29_08185
JASFJQ89_25120
JLVG3257_08340
JRIP9875_08610
MNRACZ75_11680
MASYDPH57_12210
MENYLSQ66_04000
MASZC9I28_09765
MFLAGO485_23875
MPLIE1742_23455
TCTPX653_13240
EHBE7V67_006890
EBAebA4268(algD)
AZOazo3269(algD)
AOAdqs_3408
ACOMCEW83_18780
APPCAP2UW1_0858 CAP2UW1_1431
ARUIG6M88_17210
RHLLPU83_pLPU83d0171(algD1) LPU83_pLPU83d1236(algD3)
RGRFZ934_26065
RROSD4A92_02485 D4A92_22670
RSULN2599_29805
BJAblr6296(blr6296)
BRABRADO7047
BRSS23_62720
BRCBCCGELA001_11045
BICLMTR13_08410
BRKCWS35_18850
BRQCIT40_06180
BSYMCIT39_05020
BARHWN72_18950
BELBE61_69060
BSEPHAP48_0031560
BQBJ4P68_0032835
BAUTQA635_27835
BBRAQA636_29730
BPAHQA639_16165
MNOMnod_5882
METIDK427_06650
MTEZHPT29_006150
BIDBind_3885
MPARF7D14_18240
MAADAZF01_02675
MMEDMame_02304(algD)
MLUTJET14_03725
JAVOXU80_00280
RBMTEF_19885
LABRCHH27_22980
LABPFJ695_16660
RPOPK1718_15110
ACUTMRB58_00060
DSHDshi_1896(algD)
MALGMALG_02776
CONTQ29_00725
YPACCEW88_18640
YANAYJ57_24995
SULZC1J03_23160
TOMBWR18_20775
THAACFI11_06320 CFI11_06490
RMHLVO79_06000
HATRC74_06375
LSALKBK07_17255
TRYQF118_01765
THWBMG03_12925
LITFPZ52_00565
PPRUFDP22_22880
POZI0K15_05930
CACTHZ995_12210
HDHG5B40_09200
AMYLQBD29_07855
FAQG5B39_18330
NARSaro_3220
SPHITS85_22025
SSANNX02_04640
ACOBP0Y56_12580
EGNBMF35_a0516
ERFFIU90_00265(algD)
PHZCHX26_00290
POTE2E27_01460
RAPRHOA_PB0089(algD)
HTQFRZ44_03090(algD)
HADHFRZ61_03380(algD)
SNEANBZ79_19285
NISNIS_0191
CMEDFE773_08555
CPAFC6V80_01890
DVEDESUT3_23450(algD)
DSADesal_3469
DTOTOL2_C36540(algD)
BMXBMS_2990
PARHI5S86_05480
HSGHPPSJP_3770(rkpK)
MSMMSMEG_5957(algD)
MSGMSMEI_5797
MSBLJ00_29460
MSNLI99_29465
MSHLI98_29470
MVAMvan_1699
MSPMspyr1_41390
MNED174_24385
MYNMyAD_23925
MTYMTOK_31270(algD)
MSARMSAR_24600(algD)
MANYMANY_49000(algD)
MPOFMPOR_19690
MGOAFA91_10990 AFA91_29875
MRFMJO55_24360
MDFK0O62_25565
NHUH0264_19875
ROPROP_57960(algD)
RKOJWS14_31405
TOYFO059_04060
SCOSCO0382(SCF62.08)
SGRFSGFS_035730
SCBSCAB_23351
SVLStrvi_5599
SHYSHJG_7006
SHOSHJGH_6766
SRCM271_40840
SBHSBI_09543
SVESVEN_7199
SLVSLIV_36030(algD)
SVTSVTN_36100
STREGZL_08291
SLDT261_7968
SPRISPRI_2000
STRFASR50_26930
SPAVSpa2297_31800
STRTA8713_24610
SCLFBB341_00345
SGSAVL59_31095
SALWCP975_03365
SGMGCM10017557_19510
SLSSLINC_8140
SNRSNOUR_37270(algD)
SALUDC74_1121
SALLSAZ_06100
SPLULK06_025850
STRDNI25_00640
SSIAA7J05_09315
SGVB1H19_04475
SALFSMD44_08071(algD)
STROSTRMOE7_01550
SFKKY5_0166c
SGEDWG14_01282(algD_2)
SLKSLUN_34570
SQZFQU76_01535
SCYAEJ357_37150
SKACP970_42095
SVRCP971_03305
SFYGFH48_34990
SBYH7H31_29485
SFUGCNQ36_29650
STSUB7R87_32065
SCHACP983_11050
SGXH4W23_37670
SCOECP976_05755
SSPBCP982_01460
SHUNDWB77_00748(algD)
SCYGS1361_04630(algD)
SFEUIM697_33530
SROIIAG44_00725
SXNIAG42_07115
SGJIAG43_29305
SHKJ2N69_02610
SINEKI385_03390
SLFJEQ17_08420
SAOVG3H79_06935
SDURM4V62_06475
STAALDH80_04755
SLONLGI35_03160
STEEF3L20_11870
SYUNMOV08_38485
SARGHKX69_08010
SJNRI060_36395
SCYNN8I84_34940
SKGKJK29_33180
SFPQUY26_02885
STRZOYE22_28860
HEAHL652_13685
ACHAchl_2940
TEHGKE56_16015
NDKI601_0111(algD)
KSLOG809_26460
SROSros_0655
NOABKM31_42710
NGNLCN96_02635
NFSOIE67_44765
BSDBLASA_0423(algD)
AMDAMED_0547(algD)
AMNRAM_02805
AMMAMES_0545(algD)
AMZB737_0546(algD)
AOIAORI_0554(algD)
AJAAJAP_36870(algD)
AMQAMETH_0542(ugd)
AMYBBKN51_36975
AMYYYIM_21485(algD)
AORISD37_38440
AACDLWP59_02525
APRTMUY14_33840
AROONQK81_20050
ATHML1857_05310
ARHDVSH64_40365
AMOGQRX60_08495
PDXPsed_1848
PBROHOP40_15385
PPELH6H00_14920
KUTJJ691_61590(algD)
KBUQ4V64_06025
PMADBAY61_02365
ACTYOG774_25565
HAOPCC7418_0427
NPUNpun_F5503
NSHGXM_00034
CTHEChro_0719
STISthe_1134
DAHDAETH_33720
DMBE5F05_17350
SLOMPXH66_05790
ROOG5S37_25645
FPESNXS98_06570
AHELQ31a_57060(algD)
SMAMMal15_36880(algD)
MRIMal4_03640(algD)
SDYNMal52_06430(algD)
FTJFTUN_5650
ABAAcid345_3792
TRSTerro_2830
ADINH7849_05985
SUSAcid_0553
LUBTBR22_A24300(algD)
BDOEL88_09425
NKONiako_7100
CMRCycma_0720
EMAIKZP23_20245
SPIBG8759_29085
SRHOHH216_01470
SENFGJR95_15585
DSNHWI92_00320
FIBA6C57_20705
PKOPKOR_16530
CLITOQ292_40240
PRHOPZB74_20200
TPELP0M28_17740
ZGAZOBELLIA_1984(algD)
PPONMUN68_016515
CACICLOAM0663
TAMTheam_0797
NMVNITMOv2_2630(algD)
NNEOPQG83_09560
SCHVBRCON_1950
 » show all
Reference
1  [PMID:14245351]
  Authors
PREISS J.
  Title
SUGAR NUCLEOTIDE REACTIONS IN ARTHROBACTER. II. BIOSYNTHESIS OF GUANOSINE DIPHOSPHOMANNURONATE.
  Journal
J Biol Chem 239:3127-32 (1964)
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.132
IUBMB Enzyme Nomenclature: 1.1.1.132
ExPASy - ENZYME nomenclature database: 1.1.1.132
BRENDA, the Enzyme Database: 1.1.1.132
CAS: 37250-63-8

DBGET integrated database retrieval system