KEGG   ENZYME: 1.1.1.136Help
Entry
EC 1.1.1.136                Enzyme                                 

Name
UDP-N-acetylglucosamine 6-dehydrogenase;
uridine diphosphoacetylglucosamine dehydrogenase;
UDP-acetylglucosamine dehydrogenase;
UDP-2-acetamido-2-deoxy-D-glucose:NAD oxidoreductase;
UDP-GlcNAc dehydrogenase;
WbpA;
WbpO
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
UDP-N-acetyl-alpha-D-glucosamine:NAD+ 6-oxidoreductase
Reaction(IUBMB)
UDP-N-acetyl-alpha-D-glucosamine + 2 NAD+ + H2O = UDP-2-acetamido-2-deoxy-alpha-D-glucuronate + 2 NADH + 2 H+ [RN:R00421]
Reaction(KEGG)
Substrate
UDP-N-acetyl-alpha-D-glucosamine [CPD:C00043];
NAD+ [CPD:C00003];
H2O [CPD:C00001]
Product
UDP-2-acetamido-2-deoxy-alpha-D-glucuronate;
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
This enzyme participates in the biosynthetic pathway for UDP-alpha-D-ManNAc3NAcA (UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-mannuronic acid), an important precursor of B-band lipopolysaccharide.
History
EC 1.1.1.136 created 1972, modified 2012
Pathway
ec00520  Amino sugar and nucleotide sugar metabolism
Orthology
K13015  UDP-N-acetyl-D-glucosamine dehydrogenase
K22926  UDP-N-acetylglucosamine 6-dehydrogenase
Genes
STY: STY4661(tviB)
STT: t4352(tviB)
SEX: STBHUCCB_46080
SENT: TY21A_22165
SEI: SPC_4466(tviB)
CBRA: A6J81_21660
PLU: plu4796(wblA)
PLUM: A4R40_23855
PAY: PAU_04311(udg)
PTT: VY86_07515
XBO: XBJ1_4313
XNE: XNC1_0111
XNM: XNC2_0113
PAE: PA3159(wbpA)
PAEV: N297_3270
PAEI: N296_3270
PAEM: U769_09122
PAEC: M802_3268
PAEO: M801_3135
PMY: Pmen_1857
PMK: MDS_1965
PPUH: B479_06895
PSTT: CH92_13925
PSES: PSCI_2865
PSOS: POS17_4986
PSET: THL1_1976
PSEO: OM33_04945
LFA: LFA_0787
LOK: Loa_02108
ADI: B5T_01707(wbpA)
AHA: AHA_4168
NWE: SAMEA3174300_0092(tuaD)
CVI: CV_4129(udg)
AMAH: DLM_4445
REH: H16_B0034(wecC)
BOK: DM82_847
BOC: BG90_83
PBH: AAW51_5179(wbpA)
GUR: Gura_1673
GLO: Glov_1508
MXA: MXAN_2689
CCX: COCOR_05351(wecC)
SCL: sce0875
BBAT: Bdt_1671(wecC)
BBW: BDW_05945
MLO: mlr3262
MES: Meso_0487
RBS: RHODOSMS8_00379(wbpA)
SMER: DU99_29590
SMD: Smed_4589
SFD: USDA257_c32420(capL)
ATU: Atu2582
AVI: Avi_3939
RLE: pRL110056
RLG: Rleg_7121
RIR: BN877_I2667(wbpA)
NEN: NCHU2750_39560(wbpA)
SHZ: shn_26365
MET: M446_6571
MNO: Mnod_6764
MAQU: Maq22A_c18550(wecC)
HDI: HDIA_3837(wbpA)
PZU: PHZ_c2165
RDE: RD1_1493
SPHU: SPPYR_1647(wbpA)
SPHI: TS85_13605
ELI: ELI_13295
MAI: MICA_315
MAN: A11S_299
BSX: C663_3267
BAQ: BACAU_3150(vipA1)
BAMP: B938_16005
BAML: BAM5036_3038(wecC)
BAMA: RBAU_3259(wecC)
BAMN: BASU_3040(wecC)
BAMT: AJ82_17650
BAMY: V529_33850
BAO: BAMF_3250(RBAM_031240)
BQL: LL3_03533
BAMI: KSO_003510
BAMC: U471_32410
BAMF: U722_16770
BTI: BTG_07625
BMYC: DJ92_2327
BACP: SB24_13130
BEO: BEH_04455
BGY: BGLY_0829
AAMY: GFC30_482
VPN: A21D_01755(wbpA_3)
LIV: LIV_2638
PPY: PPE_03756
PPM: PPSC2_19825(wecC)
PPO: PPM_3970(wecC)
PPOL: X809_35915
PPQ: PPSQR21_039990(wecC)
PPOY: RE92_17360
PLV: ERIC2_c20320(wecC)
CML: BN424_3059(wecC)
CAE: SMB_G3347
CAY: CEA_G3313
CBO: CBO3108
CBA: CLB_3137
CBH: CLC_3010
CBY: CLM_3514
CBL: CLK_2502
CBB: CLD_1432
CBI: CLJ_B3374
CBN: CbC4_0992
CBF: CLI_3167
CBM: CBF_3156
CBE: Cbei_4880
CSR: Cspa_c19780(wbpA1) Cspa_c55370(wbpA2)
CSB: CLSA_c41650(wbpA1) CLSA_c43270(wbpA2)
CSQ: CSCA_4788
CLD: CLSPO_c32030(wbpA)
CACE: CACET_c17700(ugd)
CTYK: CTK_C08650
HSC: HVS_10085(wbpA1)
CCEL: CCDG5_0708(wbpA)
DSY: DSY3346
DHD: Dhaf_4504
PTH: PTH_1076(WecC)
SGY: Sgly_3010
ELM: ELI_2562
SAY: TPY_3675(wbpA)
TTE: TTE0652(WecC)
TKI: TKV_c06630(wbpA)
CSC: Csac_1803
ATE: Athe_1238
TOC: Toce_1591
MVQ: MYVA_4878
SBH: SBI_04910
SALS: SLNWT_1072
STRM: M444_35900
SLAU: SLA_0653
SLX: SLAV_00070(wbpA1) SLAV_39320(wbpA3)
KSK: KSE_46620
FAL: FRAAL2058
NML: Namu_5249
SESP: BN6_30100
KAL: KALB_5211
ASE: ACPL_5657(wbpA) ACPL_5728(wecC)
AFS: AFR_11625
CAI: Caci_7640
HHG: XM38_017770(wbpA_1) XM38_038440(wbpA_2)
GLJ: GKIL_0464
CALH: IJ00_16870
RCA: Rcas_3083
CAU: Caur_2110
CAG: Cagg_1553
ATM: ANT_31630
ABAT: CFX1CAM_0216(wbpA)
PBF: CFX0092_A3082(wbpA)
DFC: DFI_17245
TTH: TT_C0288
PUV: PUV_00160(capL)
WCH: wcw_1822(wblA)
RBA: RB2515
PSL: Psta_2014
PIR: VN12_06895(wbpA_1)
PLM: Plim_4103
PLS: VT03_02730(wbpA)
PLH: VT85_08590(wbpA_1)
FMR: Fuma_05615(wbpA)
TTF: THTE_1439
GES: VT84_25270(wbpA)
IPA: Isop_3742
SACI: Sinac_3897
PBOR: BSF38_00706(wbpA_1)
KST: KSMBR1_0908(ugd_1) KSMBR1_0928(ugd_3) KSMBR1_3225
PBU: L21SP3_00972(wbpA)
PBP: STSP1_00681(wbpA_2)
PBAS: SMSP2_01893(wbpA)
TPED: TPE_0208
ACA: ACP_1491
ABAS: ACPOL_2421
SUS: Acid_4597
ABAC: LuPra_03281(wbpA)
TLI: Tlie_1826
GAU: GAU_0583(wecC) GAU_1964
GBA: J421_3569
IAL: IALB_1425(wbpA)
MRO: MROS_2690
DTN: DTL3_0339(wbpA)
CABY: Cabys_2468
DTU: Dtur_0575
LFC: LFE_2226
MOX: DAMO_0218
MFC: BRM9_0458
METM: MSMTP_0771
HSU: HLASF_0927(ugd1)
HSF: HLASA_0917(ugd1)
NCT: NMSP_0130(wecC)
 » show all
Taxonomy
Reference
1  [PMID:4312076]
  Authors
Fan DF, John CE, Zalitis J, Feingold DS.
  Title
UDPacetylglucosamine dehydrogenase from Achromobacter georgiopolitanum.
  Journal
Arch Biochem Biophys 135:45-9 (1969)
DOI:10.1016/0003-9861(69)90514-1
Reference
2  [PMID:15226302]
  Authors
Miller WL, Wenzel CQ, Daniels C, Larocque S, Brisson JR, Lam JS
  Title
Biochemical characterization of WbpA, a UDP-N-acetyl-D-glucosamine 6-dehydrogenase involved in O-antigen biosynthesis in Pseudomonas aeruginosa PAO1.
  Journal
J Biol Chem 279:37551-8 (2004)
DOI:10.1074/jbc.M404749200
  Sequence
[pae:PA3159]
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.136
IUBMB Enzyme Nomenclature: 1.1.1.136
ExPASy - ENZYME nomenclature database: 1.1.1.136
BRENDA, the Enzyme Database: 1.1.1.136
CAS: 9054-83-5

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