KEGG   ENZYME: 1.1.1.149
Entry
EC 1.1.1.149                Enzyme                                 
Name
20alpha-hydroxysteroid dehydrogenase;
20alpha-hydroxy steroid dehydrogenase;
20alpha-HSD;
20alpha-HSDH
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
20alpha-hydroxysteroid:NAD(P)+ 20-oxidoreductase
Reaction(IUBMB)
17alpha,20alpha-dihydroxypregn-4-en-3-one + NAD(P)+ = 17alpha-hydroxyprogesterone + NAD(P)H + H+ [RN:R03325]
Reaction(KEGG)
R03325;
(other) R02207 R02209 R08958 R08959
Substrate
17alpha,20alpha-dihydroxypregn-4-en-3-one [CPD:C04518];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006]
Product
17alpha-hydroxyprogesterone [CPD:C01176];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Re-specific with respect to NAD(P)+ (cf. EC 1.1.1.62 17beta-estradiol 17-dehydrogenase).
History
EC 1.1.1.149 created 1972, deleted 1983, reinstated 1986
Pathway
ec00140  Steroid hormone biosynthesis
ec01100  Metabolic pathways
Orthology
K00212  20alpha/3alpha-hydroxysteroid dehydrogenase / dihydrodiol dehydrogenase
K05295  20alpha-hydroxysteroid dehydrogenase
Genes
HSA: 1645(AKR1C1)
PTR: 100607996
PPS: 100986729
GGO: 101146324 115936027
PON: 100171658(AKR1C1) 100189776
PPYG: 129006867 129006872
NLE: 100605934
SSYN: 129491830
MCC: 711198(AKR1C1) 711360(AKR1C2)
MCF: 101865536(AKR1C1) 102141103
MTHB: 126963006 126963009
MNI: 105490781 105490782
CSAB: 103237807 103237808
CATY: 105587685 105587688
PANU: 101023297
TGE: 112631308 112631309
MLEU: 105532487 105532488 105532490
RRO: 104678925
RBB: 108532991 108532992
TFN: 117083548 117083560 117087703 117087714
CANG: 105521701 105521702
CJC: 100404656(AKR1C1)
SBQ: 101042532
CIMI: 108285104
ANAN: 105710885
MMU: 105349(Akr1c18) 77337(Akr1c21)
MCAL: 110308710
MPAH: 110315750 110333790
RNO: 171516(Akr1c3) 291283(Akr1c2) 307092(Akr1c1)
MCOC: 116081947
ANU: 117713814 117713854
MUN: 110539888 110540933 110542801 132649305
CGE: 100768666 100770100 100770388
MAUA: 101839651 101841800 101843587
PROB: 127229804 127229811
PLEU: 114707814 114708002 114708030
MORG: 121432666
MFOT: 126501693
AAMP: 119816162 119817583
NGI: 103725895
HGL: 101716553
CPOC: 100722094 100724342 100724620
CCAN: 109680485
DORD: 105980417
DSP: 122113030
MMMA: 107134068 107150203
OCU: 100348607(PGER1) 100352716
OPI: 101525116 101525279 101526245 118759111
ECB: 100070570
EPZ: 103540778
EAI: 106827244
DNM: 101433871 101435315
GAS: 123247018 123248678
AFZ: 127564339
TVP: 118850247 118850334
MUO: 115477556
GSH: 117364122
BBEL: 109473367
HAME: 121859286
 » show all
Reference
1  [PMID:4382486]
  Authors
Shikita M, Inano H, Tamaoki B.
  Title
Further studies on 20-alpha-hydroxysteroid dehydrogenase of rat testes.
  Journal
Biochemistry 6:1760-4 (1967)
DOI:10.1021/bi00858a026
Reference
2  [PMID:6935192]
  Authors
Strickler RC, Tobias B, Covey DF
  Title
Human placental 17 beta-estradiol dehydrogenase and 20 alpha-hydroxysteroid dehydrogenase. Two activities at a single enzyme active site.
  Journal
J Biol Chem 256:316-21 (1981)
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.149
IUBMB Enzyme Nomenclature: 1.1.1.149
ExPASy - ENZYME nomenclature database: 1.1.1.149
BRENDA, the Enzyme Database: 1.1.1.149
CAS: 9040-08-8

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Pathway (4)   
   KEGG PATHWAY (4)   
Chemical substance (13)   
   KEGG COMPOUND (13)   
Chemical reaction (7)   
   KEGG REACTION (5)   
   KEGG RCLASS (2)   
Gene (104)   
   KEGG ORTHOLOGY (2)   
   KEGG GENES (102)   
Protein sequence (119)   
   UniProt (77)   
   SWISS-PROT (8)   
   RefSeq(pep) (25)   
   PDBSTR (8)   
   PMD (1)   
DNA sequence (179)   
   RefSeq(nuc) (39)   
   GenBank (74)   
   EMBL (66)   
3D Structure (5)   
   PDB (5)   
Protein domain (5)   
   InterPro (5)   
All databases (436)   

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