Entry
Name
sepiapterin reductase (L-erythro-7,8-dihydrobiopterin-forming);
SR
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
L-erythro-7,8-dihydrobiopterin:NADP+ oxidoreductase
Reaction(IUBMB)
(1) L-erythro-7,8-dihydrobiopterin + NADP+ = sepiapterin + NADPH + H+ [RN:
R02975 ];
(2) L-erythro-tetrahydrobiopterin + 2 NADP+ = 6-pyruvoyl-5,6,7,8-tetrahydropterin + 2 NADPH + 2 H+ [RN:
R08208 ]
Reaction(KEGG)
Substrate
L-erythro-7,8-dihydrobiopterin [CPD:
C02953 ];
NADP+ [CPD:
C00006 ];
L-erythro-tetrahydrobiopterin [CPD:
C00272 ]
Product
Comment
This enzyme catalyses the final step in the de novo synthesis of tetrahydrobiopterin from GTP. The enzyme, which is found in higher animals and some fungi and bacteria, produces the erythro form of tetrahydrobiopterin. cf. EC
1.1.1.325 , sepiapterin reductase (L-threo-7,8-dihydrobiopterin-forming).
History
EC 1.1.1.153 created 1972, modified 2012
Pathway
Orthology
Genes
PROB : 127235711(Spr) 127235807
MORG : 121437666 121438004 121439100
AAMP : 119806836 119806924 119808275
NGI : 103726969(Spr) 103752218
NCAR : 124962824 124963156 124963266 124963639 124991413
MMMA : 107137175 107137176
GAS : 123233119 123234502(SPR)
TVP : 118841909 118841910 118843720
PBRV : 138145006 138146150
CMY : 102948309(SPR) 114021677
DCC : 119855109(SPR) 119857258
PMUR : 107295866(SPR) 107302135
RTEM : 120924570 120924571 120925066
DRE : 554136(spra) 795445(sprb)
SRX : 107712600 107726883 107745331
SANH : 107661521 107674926
SGH : 107568099 107569671 107597947
CCAR : 109053846 109094786
CAUA : 113052643 113083332 113084596 113106704
CGIB : 127964112 127992831 128018079
PTET : 122343100(spra) 122350370(sprb)
LROH : 127166148(spra) 127169424(sprb)
OMC : 131540576(spra) 131546321(sprb)
PPRM : 120464079(sprb) 120471739(spra)
RKG : 130076745(sprb) 130079883(spra)
MAMB : 125267854(spra) 125279804(sprb)
CIDE : 127512617 127517389
CERY : 137026170(sprb) 137034672(spra)
MASI : 127414581 127423884 127436122
TROS : 130568667(sprb) 130570304(spra)
TDW : 130420068(spra) 130440007(sprb)
MANU : 129413584(sprb) 129440757(spra)
CMAO : 118812918(sprb) 118814531(spra)
CHAR : 105889091(sprb) 105890031(spra)
TFS : 130517539 130525407(sprb)
TNG : GSTEN00037896G001 GSTEN00037979G001
LCO : 104920805 104938175(spr)
TBEN : 117473192(sprb) 117478898(spra)
CGOB : 115013807 115016346(spr)
PGEO : 117443957 117453122(sprb)
GACU : 117558237 117558665(sprb)
EMAC : 134868353(spra) 134874133(sprb)
GAT : 120830717(sprb) 120832348(spra)
CLUM : 117735948(sprb) 117740391(spra)
CANA : 137778932(sprb) 137783818
CVE : 137867394(sprb) 137868783
MSAM : 119891190(sprb) 119914401(spra)
SCHU : 122865710(spra) 122876903(sprb)
CUD : 121524725 121524815 121524957
ALAT : 119019673(sprb) 119030607(spra)
PPRL : 129354311 129354983
AOCE : 111576071(spr) 111578504
MCEP : 124996449(sprA) 125011602(sprB)
CSEM : 103389188(spr) 103397717
POV : 109637014 109646421(spr)
SSEN : 122758565(spra) 122769496(sprb)
HHIP : 117768530 117771436(spra)
HSP : 118098075(spra) 118115405
PPLT : 128424796(spra) 128438931
SMAU : 118284507(spra) 118314361(sprb)
LCF : 108882372(sprb) 108900753
SLAL : 111645140 111648063(spr)
SSCV : 125979844 125987455
PTAO : 133474916(sprb) 133489979(spra)
BPEC : 110161832(spr) 110167051
BSPL : 114861985(sprb) 114866420(spra)
SJO : 128365107(sprb) 128380633(spra)
ARUT : 117403601 117403851
LCM : 102345265 102356207(SPR)
BFO : 118409801 118412662 118414398 118423522 118427753 118430567
BBEL : 109465705 109465740 109469799 109474867 109474973 109475535 109479954
SPU : 577750 578162 584912
LPIC : 129272984 129273064
SKO : 100369549 100369582 102804203
DME : Dmel_CG12116(CG12116) Dmel_CG12117(Sptr)
DSI : Dsimw501_GD16109(Dsim_GD16109) Dsimw501_GD16111(Dsim_GD16111)
DYA : Dyak_GE17449 Dyak_GE17450
DGR : 122322457 6565283 6565284 6570910
DMO : Dmoj_GI14857 Dmoj_GI14858
CCAT : 101454157 101462454 101462636
RZE : 108369356 108369357 108369359
TDA : 119663321 119663323 119664132 119665139 119671279 119671281 119671282 119671294 119671340
MDE : 101889810 101896886 101897057
SCAC : 106087825 106087827
ECOE : 129945787 129947182 129947886
CPII : 120413633 120429870
PBAR : 105430754 105430755 105430757
OBO : 105275379 105275385 105278130 105286425
TPRE : 106652470 106652649
CGLO : 123260985 123261214 123261444 123261558 123263589
DAM : 107045712 107045713 107045744
DSM : 124409222 124409224 124409225
NPT : 124218099 124218100 124218101
NFB : 124180211 124180212 124180213
NLO : 107223385 107223386 107223398
NVG : 124302716 124302717 124302883
AROA : 105683747 105691343
SOY : 115891624 115891651 115891673
FCD : 110844231 110854528 110863138
PTRU : 123520597 123520616
LSM : 121118329 121118513 121118814
RSAN : 119385876 119387192 119387230 119387231
LGI : LOTGIDRAFT_114065 LOTGIDRAFT_162251
HRJ : 124258582 124258583 124292287
HASI : 137256012 137256339
MYI : 110454024 110454028 110460545 110464714 110464720 110464721 110464725 110464726 110464727 110464729 110464730 110464731 110464732 110464734
PMAX : 117330626 117343119 117343121 117343267 117343269 117343270 117343643 117343647 117343789 117343790 117344035 117344036 117344136 117344217 117344453
AIRR : 138314872 138314874 138315053 138315058 138315059 138315415 138315416 138315417 138315972 138316860 138316957
DPOL : 127855432 127855892
AQU : 100633666 100635251 100637027 100637154 100639131
DFA : DFA_01058 DFA_01076(sr)
TPS : THAPSDRAFT_261572(SPR1)
PIF : PITG_11445 PITG_15704
PSOJ : PHYSODRAFT_250051 PHYSODRAFT_498838
SSAO : 94298330(SS50377_24307) 94298338(SS50377_24315)
» show all
Taxonomy
Reference
Authors
Kato S.
Title
Sepiapterin reductase from horse liver: purification and properties of the enzyme.
Journal
Reference
Authors
Matsubara M, Katoh S, Akino M, Kaufman S.
Title
Sepiapterin reductase.
Journal
Reference
Authors
Werner ER, Schmid M, Werner-Felmayer G, Mayer B, Wachter H.
Title
Synthesis and characterization of 3H-labelled tetrahydrobiopterin.
Journal
Reference
Authors
Kim YA, Chung HJ, Kim YJ, Choi YK, Hwang YK, Lee SW, Park YS
Title
Characterization of recombinant Dictyostelium discoideum sepiapterin reductase expressed in E. coli.
Journal
Mol Cells 10:405-10 (2000)
Sequence
Other DBs
ExPASy - ENZYME nomenclature database: 1.1.1.153