KEGG   ENZYME: 1.1.1.154
Entry
EC 1.1.1.154                Enzyme                                 
Name
ureidoglycolate dehydrogenase [NAD(P)+];
ureidoglycolate dehydrogenase (ambiguous)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
(S)-ureidoglycolate:NAD(P)+ oxidoreductase
Reaction(IUBMB)
(S)-ureidoglycolate + NAD(P)+ = N-carbamoyl-2-oxoglycine + NAD(P)H + H+ [RN:R02935 R02936]
Reaction(KEGG)
R02935 R02936
Substrate
(S)-ureidoglycolate [CPD:C00603];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006]
Product
N-carbamoyl-2-oxoglycine [CPD:C00802];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Involved in catabolism of purines. The enzyme from the bacterium Arthrobacter allantoicus can use both NAD+ and NADP+ with similar activity. cf. EC 1.1.1.350, ureidoglycolate dehydrogenase (NAD+).
History
EC 1.1.1.154 created 1976, modified 2025
Pathway
ec00230  Purine metabolism
ec01100  Metabolic pathways
Reference
1  [PMID:4399430]
  Authors
van der Drift C, van Helvoort PE, Vogels GD.
  Title
S-ureidoglycolate dehydrogenase: purification and properties.
  Journal
Arch Biochem Biophys 145:465-9 (1971)
DOI:10.1016/S0003-9861(71)80006-1
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.154
IUBMB Enzyme Nomenclature: 1.1.1.154
ExPASy - ENZYME nomenclature database: 1.1.1.154
BRENDA, the Enzyme Database: 1.1.1.154
CAS: 62213-62-1

  All links  
Protein sequence (5312)   
   UniProt (969)   
   RefSeq(pep) (4327)   
   PDBSTR (16)   
DNA sequence (76934)   
   RefSeq(nuc) (61051)   
   GenBank (8200)   
   EMBL (7683)   
3D Structure (5)   
   PDB (5)   
All databases (82251)   

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