KEGG ENZYME: 1.1.1.16

ENZYME: 1.1.1.16

Entry

EC 1.1.1.16                 Enzyme

Name

galactitol 2-dehydrogenase;
dulcitol dehydrogenase;
AtuSorbD (gene name);
galactitol:NAD+ 2-oxidoreductase

Class

Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor

Sysname

galactitol:NAD+ 2-oxidoreductase (D-tagatose-forming)

Reaction(IUBMB)

galactitol + NAD+ = D-tagatose + NADH + H+ [RN:R02928]

Reaction(KEGG)

R02928

Substrate

galactitol [CPD:C01697];
NAD+ [CPD:C00003]

Product

D-tagatose [CPD:C00795];
NADH [CPD:C00004];
H+ [CPD:C00080]

Comment

Also converts other alditols containing an L-threo-configuration adjacent to a primary alcohol group into the corresponding sugars. The enzyme from Agrobacterium fabrum C58 is part of D-altritol and galactitol degradation pathways.

History

EC 1.1.1.16 created 1961

Pathway

ec00052

Galactose metabolism

ec01100

Metabolic pathways

Orthology

K21620

galactitol 2-dehydrogenase

Genes

POR:	APT59_10850

PPSL:

BJP27_02120

PST:	PSPTO_0363(polS)

PSB:

Psyr_4813

PSYR:

N018_01410

PSAV:

PSA3335_26670

PAMG:

BKM19_027915

PAVL:

BKM03_02055

PVD:	CFBP1590_0488(polS)

PCAB:

JGS08_24710

PCOF:

POR16_23670

PTRE:

I9H09_23500

PSYI:

MME58_24620

PFE:	PSF113_2963

PZA:	HU749_011810 HU749_015480

PFS:	PFLU_2474(polS)

PFC:	PflA506_3106

PFB:

VO64_5607

PMAN:

OU5_1018(polS)

PTV:	AA957_02490

PVR:	PverR02_18665

PAZO:

AYR47_19065

POI:	BOP93_10345

PRX:	HRH33_11685

PMUD:

NCTC8068_01964(polS_1)

PTOL:

I7845_16645

PMAB:

U0037_12380

PFW:	PF1751_v1c21680

PFF:	PFLUOLIPICF725870

PFX:	A7318_10300

PBA:	PSEBR_a2028 PSEBR_a2675

PBC:	CD58_14260

PSK:	U771_12995

PRH:	LT40_10805

PANR:

A7J50_3301

PSIL:

PMA3_10455

PYM:	AK972_2337

PGG:	FX982_03927

PVK:	EPZ47_14240

PBZ:	GN234_04320

PTRT:

HU722_0012385

PSAM:

HU731_003865

PASG:

KSS96_12820

PALV:

KSS97_15230

PCAS:

LOY40_14575

PPEG:

KUA23_11395

PNB:	NK667_09855

PCUC:

PSH97_15100

PPAE:

LDL65_22250

PPAO:

K3169_17970

PRHZ:

CRX69_17090

PSKU:

KUIN1_48210

PSNC:

C0058_18900

PBEJ:

PSH84_20130

PKV:	QYQ93_12250

PQE:	OSC50_14105

PBEN:

V6W80_10880

HALC:

EY643_16825

COBD:

U0O11_05705

COBC:

F8A90_05945

MRZ:	KDW95_00050

BBRO:

BAU06_25235

BOH:	AKI39_23995

BGM:	CAL15_12945

MLO:

mll4921

MLN:	A9174_02785

MCI:	Mesci_0549

MCIC:

A4R28_25635

MOP:	Mesop_0565

MAM:	Mesau_00523

MAMO:

A6B35_05485 A6B35_14975

MESW:

A9K65_002760

MESM:

EJ066_08300

MESP:

C1M53_05495

MHUA:

MCHK_5981

MJR:	EB229_02830

MERD:

EB233_02940

MESR:

FGU64_16685

MOH:	IHQ72_02620

MMEI:

LRP31_02770

MESJ:

MJ8_03260

MESI:

LGH82_18455 LGH82_30215

MESU:

LHFGNBLO_000689

NTU:	NTH_02646(polS)

MESO:

BSQ44_18575

MES:

Meso_3781

CHEA:

PVE73_06080

AAK:	AA2016_0205

AMIH:

CO731_00173(polS)

AMIS:

Amn_05390

ANJ:	AMD1_0189(polS)

PHT:	BLM14_16845

PHYL:

HB779_06055

ORM:	HTY61_12195

SME:	SMc01500(smoS)

SMK:	Sinme_2489

SMQ:	SinmeB_2268

SMX:	SM11_chr2594(smoS)

SMI:	BN406_02290(polS)

SMEG:

C770_GR4Chr2543

SMEL:

SM2011_c01500(smoS)

SMER:

DU99_13605

SMD:

Smed_2354

RHI:	NGR_c24700(smoS)

SFH:	SFHH103_02335

SFD:	USDA257_c49010(polS)

SIX:	BSY16_152(polS) BSY16_5965(polS)

SAME:

SAMCFNEI73_Ch2809(smoS)

SINO:

SS05631_c25770

ESJ:	SJ05684_c25430

EAK:	EKH55_2492

EMX:	FKV68_15975

ENU:	PYH37_005010

EGI:	PZN02_002185

SKM:	PZL22_002774

STEG:

QA637_12560

EAD:	OV14_3996(smoS) OV14_a1806(smoS)

EAH:	FA04_12970

ECAA:

J3R84_13350

ENP:	JVX98_26785

ATU:

Atu3164

AGR:	AGROH133_10701

ATF:	Ach5_30190

AGC:	BSY240_2751

ARUI:

G6M88_23010 G6M88_23725

AVV:	RvVAT039_08750

AVF:	RvVAR031_28580(smoS)

ASAL:

CFBP5507_23135

RIR:	BN877_II0150(polS)

ACUC:

KZ699_15255 KZ699_22335

ALEG:

CFBP4996_15095 CFBP4996_23600

AGRC:

GSF67_23305

AVI:

Avi_3571

RET:	RHE_PC00218(smoS)

REL:	REMIM1_PB00223(polS)

REP:	IE4803_PD00664(polS)

REI:	IE4771_PE00688(polS)

RLB:	RLEG3_11380

RLU:	RLEG12_12695

RHN:	AMJ98_PB00289(polS)

RHX:	AMK02_PB00304(polS)

RHK:	Kim5_PD00637(polS)

REZ:	AMJ99_PA00289(polS)

RJG:	CCGE525_24170

RHR:	CKA34_32595

RAD:	CO657_01410

ROY:	G3A56_17450 G3A56_24105

RII:	FFM53_009935

RHID:

FFM81_017900

RRG:	J3P73_03830

RLS:	HB780_13020

RROS:

D4A92_06865

RRHO:

PR018_18250

RTU:	PR017_24685

ARA:	Arad_12179

ARO:	B0909_15535 B0909_22775

SHZ:	shn_04565 shn_14200

SZO:	K8M09_12670

SOJ:	K6301_23645

SSUM:

Q9314_23820

ABAW:

D5400_04290

PDES:

FE840_017185

HOE:	IMCC20628_00250

KAI:

K32_38310

OIN:	IAR37_17055

OAN:

Oant_3850

OAH:	DR92_2641(polS)

OPS:	A8A54_22825

BPSN:

NIK97_19775

BRUC:

LJ361_14255

OCR:	HGK82_21710

OCL:	GTN27_16180

OCC:	KMS41_15640

OCH:	CES85_2928(polS)

BOP:	AXW83_06720

CHEL:

AL346_22895

MHAR:

L1P08_06350

PLEO:

OHA_1_03301(polS_1) OHA_1_03635(polS_2)

MMED:

Mame_04821(polS_2)

AUA:	M673_21990

AUB:	LXB15_00160

NOH:	G5V57_19735

PPHR:

APZ00_24405

LAP:	ACP90_06155

LABR:

CHH27_14330

LABP:

FJ695_10175

LABT:

FIU93_11795(polS1)

LAGG:

B0E33_17710

RPOP:

K1718_06600

SIW:	GH266_22880

ACUT:

MRB58_02130

SIT:	TM1040_0427

RUA:	D1823_19845

RUT:	FIU92_19295(polS)

RCON:

K3740_04435

RUY:	NOR97_18245

JAN:

Jann_2906

RPON:

G3256_16940

RFU:	ROLI_007580(polS_1) ROLI_041460(polS_3)

DSH:

Dshi_0970

PGA:	PGA1_c13170(polS)

PGL:	PGA2_c13120(polS)

PGD:

Gal_02087

PHP:	PhaeoP97_01314(polS)

PPIC:

PhaeoP14_01237(polS)

PHQ:	D1820_02715

OAT:	OAN307_c05620

OTM:	OSB_12120(polS_1)

OCT:	FTO60_03535

LMD:	METH_16205

CID:

P73_4305

CBAK:

DA792_18425

MALG:

MALG_04968

YPAC:

CEW88_07950

YAN:	AYJ57_01595

SUAM:

BOO69_11730

SULZ:

C1J03_00840

SMED:

JNX03_02275

SPSE:

SULPSESMR1_00923(polS)

TOM:	BWR18_02795

AHT:	ANTHELSMS3_00585

SAGU:

CDO87_18010

SSTL:

ABFK29_09090

THAA:

CFI11_14970

ROT:	FIV09_15180(polS2)

RMH:	LVO79_14550

MALU:

KU6B_04600(smoS)

HAT:	RC74_19275

PALX:

GQA70_11520

LSAL:

KBK07_13740

MARU:

FIU81_12545(polS)

RMAI:

MACH21_10050(smoS)

RED:	roselon_00728

RSP:	RSP_0095(smoS)

RSH:	Rsph17029_1731

RSK:	RSKD131_1411

RBL:	B6K69_06750

FYT:	QF092_06875 QF092_06880

PDE:

Pden_4841

PCON:

B0A89_13450

PZH:	CX676_14290

PARO:

CUV01_05875

PARR:

EOJ32_13865

PAAK:

FIU66_04500

PMAU:

CP157_00831(polS)

PSEW:

JHW44_06765

PFIS:

JHX87_07635 JHX87_10250

PDIM:

PAF18_15325

PFEO:

E3U26_15995

PTP:	RCA23_c18640

RHC:

RGUI_0089

TSCO:

R1T40_20225

DON:	BSK21_10535

MALC:

QQG91_10230

RBZ:	B9057_03070

THW:	BMG03_08975

TEC:	AKL02_007950

LVS:	LOKVESSMR4R_00808(polS)

YPHY:

AABB29_06515

YAG:	AABB28_01960

YRH:	AABB31_03195

GEH:	HYN69_04820 HYN69_04825

GFU:	KM031_00590

TAW:	EI545_04810

SEDI:

EBB79_07330

BOO:	E2K80_01295

PSEB:

EOK75_15730

PPRU:

FDP22_08050

MON:	G8E03_06950

POZ:	I0K15_14005

PSHQ:

F3W81_05360

THAS:

C6Y53_06840

GCE:	KYE46_07860

GYJ:	AADW23_10530

NSM:	JO391_00690

AALK:

LGT41_0009965

AMYL:

QBD29_02505

PBAE:

P8S53_07060

RBG:	BG454_17795

LVR:	T8T21_06090

BOSG:

GKR98_13330 GKR98_14255

MANH:

LA6_000732(polS_1)

FAQ:	G5B39_12405

RCP:	RCAP_rcc02026(polS)

RHP:	LPB142_03210

RBX:	I3V23_06200

SWI:

Swit_2003

SPHD:

HY78_15500

SPMI:

K663_10530

SPHJ:

BSL82_04710 BSL82_08735

ABG:	Asbog_02664

NCH:	A0U93_11725

LCK:	HN018_13780

KHA:	IFJ82_09215

KDP:	N5W20_07490

NGU:	QN315_13810

AZL:	AZL_b04800(gutB)

ATI:	AL072_19185

AZZ:	DEW08_00830

AZP:	E6C67_05755

SKT:	IGS68_30845

MAGQ:

MGMAQ_0165(polS)

APC:	HIMB59_00005670

APB:	SAR116_0966

DMS:	E8L03_11670

AORY:

AMOR_06280(smoS)

LPAV:

PLANPX_3313

HPRI:

P0082_11525

LCZ:	LCAZH_2763

LCL:	LOCK919_3014

LPI:	LBPG_01355

LCX:	LCA12A_0449

LACY:

A4V08_22630

AMN:

RAM_17780

AMM:

AMES_3457

AMZ:

B737_3457

RXY:

Rxyl_3047

RMAR:

GBA65_02020

» show all

Reference

1 [PMID:13373783]

Authors

SHAW DR.

Title

Polyol dehydrogenases. 3. Galactitol dehydrogenase and D-iditol dehydrogenase.

Journal

Biochem J 64:394-405 (1956)
DOI:10.1042/bj0640394

Reference

2 [PMID:26472925]

Authors

Wichelecki DJ, Vetting MW, Chou L, Al-Obaidi N, Bouvier JT, Almo SC, Gerlt JA

Title

ATP-binding Cassette (ABC) Transport System Solute-binding Protein-guided Identification of Novel d-Altritol and Galactitol Catabolic Pathways in Agrobacterium tumefaciens C58.

Journal

J Biol Chem 290:28963-76 (2015)
DOI:10.1074/jbc.M115.686857

Sequence

[atu:Atu3164]

Other DBs

ExplorEnz - The Enzyme Database:

1.1.1.16

IUBMB Enzyme Nomenclature:

1.1.1.16

ExPASy - ENZYME nomenclature database:

1.1.1.16

BRENDA, the Enzyme Database:

1.1.1.16

CAS:

9028-23-3

DBGET integrated database retrieval system