KEGG   ENZYME: 1.1.1.16Help
Entry
EC 1.1.1.16                 Enzyme                                 

Name
galactitol 2-dehydrogenase;
dulcitol dehydrogenase;
AtuSorbD (gene name);
galactitol:NAD+ 2-oxidoreductase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
galactitol:NAD+ 2-oxidoreductase (D-tagatose-forming)
Reaction(IUBMB)
galactitol + NAD+ = D-tagatose + NADH + H+ [RN:R02928]
Reaction(KEGG)
Substrate
galactitol [CPD:C01697];
NAD+ [CPD:C00003]
Product
D-tagatose [CPD:C00795];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
Also converts other alditols containing an L-threo-configuration adjacent to a primary alcohol group into the corresponding sugars. The enzyme from Agrobacterium fabrum C58 is part of D-altritol and galactitol degradation pathways.
History
EC 1.1.1.16 created 1961
Pathway
ec00052  Galactose metabolism
Orthology
K21620  galactitol 2-dehydrogenase
Genes
PHD: 102330493
POR: APT59_10850
PSYR: N018_01410
PAMG: BKM19_027915
PAVL: BKM03_02055
PFS: PFLU_2474(polS)
PFE: PSF113_2963
PFC: PflA506_3106
PFW: PF1751_v1c21680
PFF: PFLUOLIPICF725870
PFB: VO64_5607
PMAN: OU5_1018(polS)
PANR: A7J50_3301
PSIL: PMA3_10455
MES: Meso_3781
AMIH: CO731_00173(polS)
SME: SMc01500(smoS)
SMX: SM11_chr2594(smoS)
SMI: BN406_02290(polS)
SMEL: SM2011_c01500(smoS)
SMER: DU99_13605
SIX: BSY16_152(polS) BSY16_5965(polS)
EAD: OV14_3996(smoS) OV14_a1806(smoS)
ATU: Atu3164
AVI: Avi_3571
RET: RHE_PC00218(smoS)
REL: REMIM1_PB00223(polS)
REP: IE4803_PD00664(polS)
REI: IE4771_PE00688(polS)
RIR: BN877_II0150(polS)
RHN: AMJ98_PB00289(polS)
RHX: AMK02_PB00304(polS)
RHK: Kim5_PD00637(polS)
REZ: AMJ99_PA00289(polS)
OAN: Oant_3850
OAH: DR92_2641(polS)
OCH: CES85_2928(polS)
MMED: Mame_04821(polS_2)
RSP: RSP_0095(smoS)
PGA: PGA1_c13170(polS)
PGL: PGA2_c13120(polS)
PGD: Gal_02087
PHP: PhaeoP97_01314(polS)
PPIC: PhaeoP14_01237(polS)
OTM: OSB_12120(polS_1)
CID: P73_4305
MALG: MALG_04968
RHC: RGUI_0089
SPSE: SULPSESMR1_00923(polS)
LVS: LOKVESSMR4R_00808(polS)
SPHD: HY78_15500
AZL: AZL_b04800(gutB)
MAGQ: MGMAQ_0165(polS)
 » show all
Taxonomy
Reference
1  [PMID:13373783]
  Authors
SHAW DR.
  Title
Polyol dehydrogenases.  3.  Galactitol dehydrogenase and D-iditol dehydrogenase.
  Journal
Biochem J 64:394-405 (1956)
Reference
2  [PMID:26472925]
  Authors
Wichelecki DJ, Vetting MW, Chou L, Al-Obaidi N, Bouvier JT, Almo SC, Gerlt JA
  Title
ATP-binding Cassette (ABC) Transport System Solute-binding Protein-guided Identification of Novel d-Altritol and Galactitol Catabolic Pathways in Agrobacterium tumefaciens C58.
  Journal
J Biol Chem 290:28963-76 (2015)
DOI:10.1074/jbc.M115.686857
  Sequence
[atu:Atu3164]
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.16
IUBMB Enzyme Nomenclature: 1.1.1.16
ExPASy - ENZYME nomenclature database: 1.1.1.16
BRENDA, the Enzyme Database: 1.1.1.16
CAS: 9028-23-3

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