KEGG   ENZYME: 1.1.1.16
Entry
EC 1.1.1.16                 Enzyme                                 
Name
galactitol 2-dehydrogenase;
dulcitol dehydrogenase;
AtuSorbD (gene name);
galactitol:NAD+ 2-oxidoreductase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
galactitol:NAD+ 2-oxidoreductase (D-tagatose-forming)
Reaction(IUBMB)
galactitol + NAD+ = D-tagatose + NADH + H+ [RN:R02928]
Reaction(KEGG)
R02928
Substrate
galactitol [CPD:C01697];
NAD+ [CPD:C00003]
Product
D-tagatose [CPD:C00795];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
Also converts other alditols containing an L-threo-configuration adjacent to a primary alcohol group into the corresponding sugars. The enzyme from Agrobacterium fabrum C58 is part of D-altritol and galactitol degradation pathways.
History
EC 1.1.1.16 created 1961
Pathway
ec00052  Galactose metabolism
ec01100  Metabolic pathways
Orthology
K21620  galactitol 2-dehydrogenase
Genes
PORAPT59_10850
PSBPsyr_4813
PSYRN018_01410
PSAVPSA3335_26670
PAMGBKM19_027915
PAVLBKM03_02055
PVDCFBP1590_0488(polS)
PCABJGS08_24710
PCOFPOR16_23670
PFEPSF113_2963
PFSPFLU_2474(polS)
PFCPflA506_3106
PFBVO64_5607
PMANOU5_1018(polS)
PTVAA957_02490
PVRPverR02_18665
PAZOAYR47_19065
POIBOP93_10345
PRXHRH33_11685
PFWPF1751_v1c21680
PFFPFLUOLIPICF725870
PFXA7318_10300
PBAPSEBR_a2028 PSEBR_a2675
PBCCD58_14260
PSKU771_12995
PRHLT40_10805
PANRA7J50_3301
PPSLBJP27_02120
PSILPMA3_10455
PYMAK972_2337
PGGFX982_03927
PVKEPZ47_14240
PBZGN234_04320
PTRTHU722_0012385
PSAMHU731_003865
PASGKSS96_12820
PALVKSS97_15230
PZAHU749_011810 HU749_015480
HALCEY643_16825
BBROBAU06_25235
BOHAKI39_23995
BGMCAL15_12945
DMSE8L03_11670
MLNA9174_02785
MCIMesci_0549
MOPMesop_0565
MAMMesau_00523
MAMOA6B35_05485 A6B35_14975
MESWA9K65_002760
MESMEJ066_08300
MESPC1M53_05495
MHUAMCHK_5981
MJREB229_02830
MERDEB233_02940
MESRFGU64_16685
MESOBSQ44_18575
MESMeso_3781
HOEIMCC20628_00250
AAKAA2016_0205
AMIHCO731_00173(polS)
PHTBLM14_16845
PHYLHB779_06055
ORMHTY61_12195
SMESMc01500(smoS)
SMKSinme_2489
SMQSinmeB_2268
SMXSM11_chr2594(smoS)
SMIBN406_02290(polS)
SMEGC770_GR4Chr2543
SMELSM2011_c01500(smoS)
SMERDU99_13605
SIXBSY16_152(polS) BSY16_5965(polS)
SINOSS05631_c25770
EADOV14_3996(smoS) OV14_a1806(smoS)
EAHFA04_12970
ESJSJ05684_c25430
EAKEKH55_2492
EMXFKV68_15975
ATUAtu3164
AGRAGROH133_10701
ATFAch5_30190
AVIAvi_3571
AGCBSY240_2751
AROB0909_15535 B0909_22775
ARUIG6M88_23010 G6M88_23725
RETRHE_PC00218(smoS)
RELREMIM1_PB00223(polS)
REPIE4803_PD00664(polS)
REIIE4771_PE00688(polS)
RLBRLEG3_11380
RLURLEG12_12695
RIRBN877_II0150(polS)
RHNAMJ98_PB00289(polS)
RHXAMK02_PB00304(polS)
RHKKim5_PD00637(polS)
REZAMJ99_PA00289(polS)
RJGCCGE525_24170
RHRCKA34_32595
RADCO657_01410
ROYG3A56_17450 G3A56_24105
RIIFFM53_009935
RHIDFFM81_017900
RRGJ3P73_03830
RLSHB780_13020
RROSD4A92_06865
SHZshn_04565 shn_14200
SZOK8M09_12670
SOJK6301_23645
ABAWD5400_04290
PDESFE840_017185
KAIK32_38310
OINIAR37_17055
OANOant_3850
OAHDR92_2641(polS)
OPSA8A54_22825
OCHCES85_2928(polS)
OCRHGK82_21710
OCLGTN27_16180
BOPAXW83_06720
CHELAL346_22895
PLEOOHA_1_03301(polS_1) OHA_1_03635(polS_2)
MMEDMame_04821(polS_2)
AUAM673_21990
AUBLXB15_00160
NOHG5V57_19735
PPHRAPZ00_24405
LAPACP90_06155
LABRCHH27_14330
LABPFJ695_10175
LABTFIU93_11795(polS1)
LAGGB0E33_17710
SIWGH266_22880
ACUTMRB58_02130
RUAD1823_19845
RUTFIU92_19295(polS)
JANJann_2906
RPONG3256_16940
DSHDshi_0970
PGAPGA1_c13170(polS)
PGLPGA2_c13120(polS)
PGDGal_02087
PHPPhaeoP97_01314(polS)
PPICPhaeoP14_01237(polS)
PHQD1820_02715
OATOAN307_c05620
OTMOSB_12120(polS_1)
OCTFTO60_03535
LMDMETH_16205
REDroselon_00728
CIDP73_4305
MALGMALG_04968
YPACCEW88_07950
YANAYJ57_01595
SUAMBOO69_11730
SULZC1J03_00840
SMEDJNX03_02275
SPSESULPSESMR1_00923(polS)
TOMBWR18_02795
AHTANTHELSMS3_00585
SAGUCDO87_18010
THAACFI11_14970
MARUFIU81_12545(polS)
ROTFIV09_15180(polS2)
RMHLVO79_14550
MALUKU6B_04600(smoS)
HATRC74_19275
PALXGQA70_11520
LSALKBK07_13740
RSPRSP_0095(smoS)
RSHRsph17029_1731
RSKRSKD131_1411
RCPRCAP_rcc02026(polS)
RHPLPB142_03210
RBLB6K69_06750
PCONB0A89_13450
PZHCX676_14290
PAROCUV01_05875
PARREOJ32_13865
PAAKFIU66_04500
PMAUCP157_00831(polS)
PTPRCA23_c18640
RHCRGUI_0089
DONBSK21_10535
THWBMG03_08975
TECAKL02_007950
LVSLOKVESSMR4R_00808(polS)
RBGBG454_17795
GEHHYN69_04820 HYN69_04825
GFUKM031_00590
TAWEI545_04810
SEDIEBB79_07330
BOOE2K80_01295
PSEBEOK75_15730
PPRUFDP22_08050
MONG8E03_06950
PSHQF3W81_05360
POZI0K15_14005
RBZB9057_03070
THASC6Y53_06840
GCEKYE46_07860
NSMJO391_00690
FAQG5B39_12405
SWISwit_2003
SPHDHY78_15500
SPMIK663_10530
SPHJBSL82_04710 BSL82_08735
ABGAsbog_02664
NCHA0U93_11725
LCKHN018_13780
KHAIFJ82_09215
AZLAZL_b04800(gutB)
ATIAL072_19185
AZZDEW08_00830
SKTIGS68_30845
MAGQMGMAQ_0165(polS)
APCHIMB59_00005670
APBSAR116_0966
LCZLCAZH_2763
LCLLOCK919_3014
LPILBPG_01355
LCXLCA12A_0449
LACYA4V08_22630
MCBMycch_2957
RHBNY08_2982
DEMLGT36_009735
MUZH4N58_10110
AMNRAM_17780
AMMAMES_3457
AMZB737_3457
RXYRxyl_3047
RMARGBA65_02020
LPAVPLANPX_3313
 » show all
Reference
1  [PMID:13373783]
  Authors
SHAW DR.
  Title
Polyol dehydrogenases.  3.  Galactitol dehydrogenase and D-iditol dehydrogenase.
  Journal
Biochem J 64:394-405 (1956)
DOI:10.1042/bj0640394
Reference
2  [PMID:26472925]
  Authors
Wichelecki DJ, Vetting MW, Chou L, Al-Obaidi N, Bouvier JT, Almo SC, Gerlt JA
  Title
ATP-binding Cassette (ABC) Transport System Solute-binding Protein-guided Identification of Novel d-Altritol and Galactitol Catabolic Pathways in Agrobacterium tumefaciens C58.
  Journal
J Biol Chem 290:28963-76 (2015)
DOI:10.1074/jbc.M115.686857
  Sequence
[atu:Atu3164]
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.16
IUBMB Enzyme Nomenclature: 1.1.1.16
ExPASy - ENZYME nomenclature database: 1.1.1.16
BRENDA, the Enzyme Database: 1.1.1.16
CAS: 9028-23-3

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