KEGG   ENZYME: 1.1.1.160
Entry
EC 1.1.1.160                Enzyme                                 
Name
dihydrobunolol dehydrogenase;
bunolol reductase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
(+/-)-5-[(tert-butylamino)-2'-hydroxypropoxy]-1,2,3,4-tetrahydro-1-naphthol:NADP+ oxidoreductase
Reaction(IUBMB)
(+/-)-5-[(tert-butylamino)-2'-hydroxypropoxy]-1,2,3,4-tetrahydro-1-naphthol + NADP+ = (+/-)-5-[(tert-butylamino)-2'-hydroxypropoxy]-3,4-dihydro-1(2H)-naphthalenone + NADPH + H+ [RN:R04623]
Reaction(KEGG)
R04623
Substrate
(+/-)-5-[(tert-butylamino)-2'-hydroxypropoxy]-1,2,3,4-tetrahydro-1-naphthol [CPD:C04875];
NADP+ [CPD:C00006]
Product
(+/-)-5-[(tert-butylamino)-2'-hydroxypropoxy]-3,4-dihydro-1(2H)-naphthalenone [CPD:C04883];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Also acts, more slowly, with NAD+.
History
EC 1.1.1.160 created 1976
Reference
1  [PMID:4560367]
  Authors
Leinweber FJ, Greenough RC, Schwender CF, Kaplan HR, Di Carlo FJ.
  Title
Bunolol metabolism by cell-free preparations of human liver: biosynthesis of dihydrobunolol.
  Journal
Xenobiotica 2:191-202 (1972)
DOI:10.3109/00498257209111050
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.160
IUBMB Enzyme Nomenclature: 1.1.1.160
ExPASy - ENZYME nomenclature database: 1.1.1.160
BRENDA, the Enzyme Database: 1.1.1.160
CAS: 62213-61-0

  All links  
Chemical substance (5)   
   KEGG COMPOUND (5)   
Chemical reaction (2)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
All databases (7)   

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