KEGG   ENZYME: 1.1.1.179
Entry
EC 1.1.1.179                Enzyme                                 

Name
D-xylose 1-dehydrogenase (NADP+, D-xylono-1,5-lactone-forming);
D-xylose (nicotinamide adenine dinucleotide phosphate) dehydrogenase (ambiguous);
D-xylose-NADP dehydrogenase (ambiguous);
D-xylose:NADP+ oxidoreductase (ambiguous);
D-xylose 1-dehydrogenase (NADP) (ambiguous)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
D-xylose:NADP+ 1-oxidoreductase (D-xylono-1,5-lactone-forming)
Reaction(IUBMB)
D-xylose + NADP+ = D-xylono-1,5-lactone + NADPH + H+ [RN:R01430]
Reaction(KEGG)
R01430
Substrate
D-xylose [CPD:C00181];
NADP+ [CPD:C00006]
Product
D-xylono-1,5-lactone [CPD:C02266];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
The enzyme, characterized from pig arterial vessels and eye lens, also acts, more slowly, on L-arabinose and D-ribose. cf. EC 1.1.1.424, D-xylose 1-dehydrogenase (NADP+, D-xylono-1,4-lactone-forming).
History
EC 1.1.1.179 created 1982, modified 2020
Pathway
ec00040  Pentose and glucuronate interconversions
ec01100  Metabolic pathways
Orthology
K00078  dihydrodiol dehydrogenase / D-xylose 1-dehydrogenase (NADP)
K14273  D-xylose 1-dehydrogenase (NADP+, D-xylono-1,5-lactone-forming)
Genes
HSA: 27294(DHDH)
PTR: 456194(DHDH)
PPS: 100991467(DHDH)
GGO: 101152398(DHDH)
PON: 100174691(DHDH)
NLE: 100591778(DHDH)
MCC: 718930(DHDH)
MCF: 102133381(DHDH)
CSAB: 103235003(DHDH)
RRO: 104666542(DHDH)
RBB: 108523635(DHDH)
CJC: 100390604(DHDH)
SBQ: 101049549(DHDH)
MMU: 71755(Dhdh)
MCAL: 110298665(Dhdh)
MPAH: 110337709(Dhdh)
RNO: 691002(Dhdh)
MUN: 110540624(Dhdh)
CGE: 100753544(Dhdh)
NGI: 103743638(Dhdh)
HGL: 101713222(Dhdh)
CCAN: 109682683(Dhdh)
OCU: 100008610(DHDH)
TUP: 102470508(DHDH)
CFA: 403786(DHDH)
VVP: 112931391(DHDH)
AML: 100477136(DHDH)
UMR: 103657108(DHDH)
UAH: 113243321(DHDH)
ORO: 101371357(DHDH)
ELK: 111160798
FCA: 101101272(DHDH)
PTG: 102948867(DHDH)
PPAD: 109253091(DHDH)
AJU: 106988698(DHDH)
BTA: 617564(DHDH)
BOM: 102280401(DHDH)
BIU: 109572213(DHDH)
BBUB: 102399742(DHDH)
CHX: 102188075(DHDH)
OAS: 101103175(DHDH)
SSC: 397337(DHDH)
CFR: 102512639(DHDH)
CDK: 105102891(DHDH)
BACU: 103008204(DHDH)
ECB: 100051521(DHDH)
EPZ: 103553311(DHDH)
EAI: 106838267(DHDH)
MYB: 102262437(DHDH)
MYD: 102770117(DHDH)
MMYO: 118655427(DHDH)
MNA: 107531900(DHDH)
HAI: 109391066(DHDH)
DRO: 112310193(DHDH)
MMF: 118639275(DHDH)
PALE: 102885391(DHDH)
RAY: 107498830(DHDH)
MJV: 108400314(DHDH)
LAV: 100660549(DHDH)
TMU: 101355202
MDO: 100030403(DHDH)
SHR: 111720213(DHDH)
PCW: 110220115(DHDH)
GGA: 777348(DHDH)
MGP: 104916162(DHDH)
CJO: 107325868(DHDH)
NMEL: 110390997(DHDH)
TGU: 115491770(DHDH)
LSR: 110481421(DHDH)
PHI: 102104923(DHDH)
PMAJ: 107199051(DHDH)
ASN: 102376323(DHDH)
AMJ: 102574630(DHDH)
PSS: 102447655(DHDH)
CMY: 102931206(DHDH)
PMUR: 107282543(DHDH)
TSR: 106538690(DHDH)
XLA: 108697264 444539(dhdh-like.1.L)
XTR: 100145807(dhdh) 448579(dhdh)
DRE: 406433(dhdh.1) 449558(dhdh.2)
SGH: 107553352 107595342(dhdh)
CCAR: 109063738(dhdh) 109075356
IPU: 100528487(dhdh)
PHYP: 113526400(dhdh)
EEE: 113576071
MZE: 101466663
NFU: 107381267(dhdh) 107381268
MALB: 109955837(dhdh)
SFM: 108930140
PKI: 111847990(dhdh)
LCM: 102353287(DHDH)
CMK: 103189533(dhdh)
RTP: 109916392(dhdh)
BFO: 118407083
CIN: 100186038
DME: Dmel_CG13280(CG13280) Dmel_CG3597(CG3597) Dmel_CG3609(CG3609)
DSI: Dsimw501_GD11964(Dsim_GD11964) Dsimw501_GD22839(Dsim_GD22839) Dsimw501_GD22840(Dsim_GD22840)
MDE: 101900891
LCQ: 111676409
AME: 412231
BIM: 100740559
BTER: 100649548
CCAL: 108630663
OBB: 114873113
SOC: 105208047
MPHA: 105835107
AEC: 105154186
ACEP: 105622679
VEM: 105560923
HST: 105186645
DQU: 106741522
LHU: 105671479
PGC: 109857477
OBO: 105284215
PCF: 106785709
NVI: 100117805
MDL: 103578346
NVL: 108560837
RMD: 113548345
ZNE: 110838823
CSCU: 111640181
CRG: 105323672
MYI: 110455909
NVE: 5505671
EPA: 110244148
ADF: 107341873
AMIL: 114975326
PDAM: 113683557
SPIS: 111325722
DGT: 114517734
PTE: PTT_14440
CNE: CNE04820
CNB: CNBE4820
SMIN: v1.2.018378.t1(symbB.v1.2.018378.t1)
SPAR: SPRG_05860
MCA: MCA0041
METL: U737_20635
MMAI: sS8_4175
MEJ: Q7A_2650
MEC: Q7C_1095
AHA: AHA_2098
ASA: ASA_2199
AMED: B224_2088
AEL: NCTC12917_01967(afr)
SALN: SALB1_3671
MFA: Mfla_1214
MMB: Mmol_1981
MEH: M301_2404
MEP: MPQ_0833(mviM)
MBAC: BN1209_1717(mviM)
BBEV: BBEV_1582
BHA: BH3843
BCL: ABC2696
BKW: BkAM31D_16055(afr_2)
GKA: GK1878
GTN: GTNG_1790
ANM: GFC28_950
AAMY: GFC30_2161
ANL: GFC29_676
AXL: AXY_19480
PSYO: PB01_01580
BLEN: NCTC4824_03507(afr_8)
BSE: Bsel_2006
PPO: PPM_2025(M1_2306)
PPOY: RE92_01815
PMW: B2K_16730
PSAB: PSAB_22875
PRI: PRIO_6414
PSWU: SY83_04270
PBK: Back11_02790(socC)
AAC: Aaci_2618
AAD: TC41_2914
SIV: SSIL_3749
MHEV: MHEL_37770
STRM: M444_32545
MOO: BWL13_00475(afr_3)
SESP: BN6_32320
CAU: Caur_3022
CAG: Cagg_3563
ATM: ANT_01810
TRA: Trad_0849
ROL: CA51_12430(afr_3) CA51_45520(afr_6)
LCRE: Pla8534_20100(afr_4)
PLS: VT03_17280(gfo_3)
PLH: VT85_08640(afr_3)
GPN: Pan110_35270(gfo_7)
MRI: Mal4_21560(afr_6)
IPA: Isop_1854
SACI: Sinac_3314
PBOR: BSF38_00094(afr_1)
AGV: OJF2_68930(afr_2)
PCOR: KS4_29150(afr_4)
ABAC: LuPra_04720(afr_6)
HHB: Hhub_2517
HMA: rrnAC2929(gfo1)
HHI: HAH_0191(gfo1)
HUT: Huta_0347
HTI: HTIA_0527
HMU: Hmuk_0258
HALL: LC1Hm_2790(xdh2)
HVO: HVO_B0029
HLA: Hlac_2419
HTU: Htur_0178
SALI: L593_09740
 » show all
Reference
1
  Authors
Wissler, J.H.
  Title
D-Xylose:NADP oxidoreductase of arterial vessels and eye lens: a new enzyme and a final link in ATP-independent cycling of reducing eqivalents in aldose-polyol-ketose interconversion.
  Journal
Hoppe-Seyler's Z Physiol Chem 358:1300-1301 (1977)
Reference
2
  Authors
Wissler, J.H.
  Title
Direct spectrophotometric and specific quantitative determination of free and bound D-xylose by analytical application of a new enzyme, D-xylose:NADP-oxidoreductase.
  Journal
Fresenius' Z Anal Chem 290:179-180 (1978)
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.179
IUBMB Enzyme Nomenclature: 1.1.1.179
ExPASy - ENZYME nomenclature database: 1.1.1.179
BRENDA, the Enzyme Database: 1.1.1.179
CAS: 83534-37-6

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