KEGG   ENZYME: 1.1.1.184Help
Entry
EC 1.1.1.184                Enzyme                                 

Name
carbonyl reductase (NADPH);
aldehyde reductase 1;
prostaglandin 9-ketoreductase;
xenobiotic ketone reductase;
NADPH-dependent carbonyl reductase;
ALR3;
carbonyl reductase;
nonspecific NADPH-dependent carbonyl reductase;
carbonyl reductase (NADPH2)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
secondary-alcohol:NADP+ oxidoreductase
Reaction(IUBMB)
R-CHOH-R' + NADP+ = R-CO-R' + NADPH + H+ [RN:R03557]
Reaction(KEGG)
Substrate
R-CHOH-R' [CPD:C01612];
NADP+ [CPD:C00006]
Product
R-CO-R' [CPD:C01450];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Acts on a wide range of carbonyl compounds, including quinones, aromatic aldehydes, ketoaldehydes, daunorubicin and prostaglandins E and F, reducing them to the corresponding alcohol. Si-specific with respect to NADPH [cf. EC 1.1.1.2 alcohol dehydrogenase (NADP+)].
History
EC 1.1.1.184 created 1983
Pathway
ec00590  Arachidonic acid metabolism
ec00790  Folate biosynthesis
ec00980  Metabolism of xenobiotics by cytochrome P450
ec01100  Metabolic pathways
Orthology
K00079  carbonyl reductase 1
K00081  carbonyl reductase 2
K00084  carbonyl reductase 3
Genes
HSA: 873(CBR1) 874(CBR3)
PTR: 458533(CBR3) 473983(CBR1)
PPS: 100982905(CBR3) 100984486(CBR1)
GGO: 101128365(CBR1) 101128728(CBR3)
PON: 100172097(CBR1) 100452311(CBR3)
NLE: 100595150(CBR1) 100595496(CBR3)
MCC: 695769(CBR3) 699655(CBR1)
MCF: 102140082(CBR3) 102141127(CBR1)
CSAB: 103218526(CBR1) 103218549(CBR3)
RRO: 104679833(CBR3) 104680046(CBR1)
RBB: 108536876(CBR1) 108536877(CBR3)
CJC: 100385429(CBR1) 100386510(CBR3)
SBQ: 101047149 101053953(CBR1)
MMU: 109857(Cbr3) 12408(Cbr1) 12409(Cbr2)
RNO: 102556347 29224(Cbr1) 304078(Cbr3) 688320 688321
CGE: 100689019(Chcr1) 100689020(Chcr2) 100689021(Cbr3) 100752270 100753466 100769845 100770118 100770405 103163344 107979845
NGI: 103730087 103736427(Cbr3) 103736428(Cbr1)
HGL: 101697950(Cbr3) 101707305 101709698 101726221
CCAN: 109685203 109685204 109685205 109702241
OCU: 100009528(CBR1) 100344189 100344439 100344692 100344949 100345202 100345459 100345716 100345975(CBR3) 100348029 100348276
TUP: 102480695 102493488(CBR1) 102493905 102493906(CBR3)
CFA: 478411 480785 487748(CBR3) 607806 610164
AML: 100463727 100482421(CBR1) 100482919(CBR3) 105237507
UMR: 103673139 103673143 103673144(CBR1) 103673146(CBR3) 103673226 103673227 103673228
ORO: 101365418 101366810
FCA: 101082844(CBR3) 101083875 101084134 101084388 101091418 102901316 105260891
PTG: 102949571 102951798 102952382(CBR3) 102962462 102963221 107180402
AJU: 106966975 106966977 106966978 106966979 106966981(CBR3) 106967000 106967001 113597014
BTA: 510180(MGC127133) 515946(CBR1) 516036(CBR3) 782391(DCXR)
BOM: 102279110(DCXR) 102279872(CBR3) 102280157 102280721
BIU: 109561438 109561446 109561452 109561468(CBR3) 109564723 109574377
PHD: 102327252 102327622 102329320(CBR3) 102329678(CBR1) 102337224
CHX: 102172669 102173507(CBR3) 102178311 106503208 108633281
OAS: 101107035(DCXR) 101114408 101114663 101114920 101115172 101115420(CBR3)
SSC: 100512990(CBR3) 100622246 396780(CBR2) 397143(CBR1)
CFR: 102513911(CBR1) 102521504(CBR3)
CDK: 105089844 105089845 105102236
BACU: 103007396 103007686(CBR3) 103015680
LVE: 103078961 103084396(CBR3) 103084663(CBR1)
OOR: 101271194 101289691(CBR1) 101289932(CBR3)
ECB: 100061454 100061622 100061690 100061787 100146938 100630657
EPZ: 103548815 103548838 103550453(CBR3) 103551108
EAI: 106831418 106831421(CBR3) 106831423 106846110
MYB: 102242410 102242716 102261932(CBR3) 106723568
MYD: 102770622(CBR3) 102773942(CBR1)
HAI: 109391219 109391220
RSS: 109446658 109446659
PALE: 102890983 102891228
LAV: 100665544 100665833 100666118 100674470
TMU: 101340783 101341292 101361316
MDO: 100015103 100015187 100015233 100025250
SHR: 100918643 100920969
OAA: 100081857(CBR1)
GGA: 418512(CBR1)
MGP: 100550018(CBR1)
CJO: 107323279
APLA: 101794661
ACYG: 106036138
TGU: 100222525(CBR1)
GFR: 102043656(CBR1)
FAB: 101809650 101821429(CBR1)
PHI: 102114609(CBR1)
PMAJ: 107211649
CCAE: 111928724
CCW: 104696752
FPG: 101915985(CBR1)
FCH: 102057061(CBR1)
CLV: 102094554
EGZ: 104128238
AAM: 106494985
ASN: 102386516
AMJ: 102575087(CBR1)
PSS: 102454231
CMY: 102941881 102945673 102946220
CPIC: 101937374(CBR1)
ACS: 100567688 100568150
PVT: 110071457 110076821 110076832
PBI: 103066276
GJA: 107119801
XLA: 108707866 108707867 108707868 496039 734804(cbr1.S)
XTR: 100145008(cbr3) 101735101 496612(cbr1)
NPR: 108791095 108791096
DRE: 337696(cbr1l) 373866(cbr1)
SRX: 107706524 107746284
SANH: 107676886(cbr1) 107681174 107692178
SGH: 107560976 107573060 107589305
CCAR: 109096114(cbr1)
IPU: 108258607(cbr1) 108279390
AMEX: 103025086(cbr1) 103044035 103044320
TRU: 101070504(cbr1)
TNG: GSTEN00018781G001
LCO: 104925597(cbr1)
NCC: 104949102
MZE: 101465189 101465758(cbr1) 101466994 101467487
OLA: 100125494(cbr1)
XMA: 102228388(cbr1) 102228648
PRET: 103476570 108166972
NFU: 107376130 107376131(cbr1)
KMR: 108250748 108250751
CSEM: 103387805(cbr1)
LCF: 108872922(cbr1)
SDU: 111223859(cbr1)
HCQ: 109510228 109515209
BPEC: 110156802 110156828 110156944 110171218 110175574
MALB: 109963832(cbr1)
SASA: 106563564(DHCA) 106563565(DHCA) 106563632 106575082(cbr1) 106586631
OTW: 112231245 112231246 112240976 112253987(cbr1)
ELS: 105010857 109614572(cbr1)
SFM: 108924735 108938298 108938305
LCM: 102349061 102367136(CBR1)
CMK: 103186742 103186743
BFO: BRAFLDRAFT_118600 BRAFLDRAFT_118601 BRAFLDRAFT_133204 BRAFLDRAFT_261426 BRAFLDRAFT_274685 BRAFLDRAFT_59475
CIN: 100182286
SPU: 574612 590243
APLC: 110973484 110973485 110973487
SKO: 100366455 100366603 100366755 100367363 100367671 100372039
AME: 551072
BIM: 100747164
BTER: 100643942
SOC: 105207948
AEC: 105144039 105150971 105151007
ACEP: 105619849 105627303
PBAR: 105424036
HST: 105186587
DQU: 106748457
CFO: 105250549
LHU: 105676624
PGC: 109853439
PCF: 106788977
TCA: 661972
DPA: 109534143 109543822
NVL: 108565934
BMOR: 101738709 101741781 101741955 101742796 101745818
DPL: KGM_201906 KGM_201907 KGM_203730 KGM_205942 KGM_211104
PMAC: 106710022 106711291 106711292 106711293 106712788 106712790 106718276 106718996 106719907 106719988
PRAP: 110991285 110994263 110999668 111000881 111000882 111000883 111000886 111000893 111000894 111000902 111001155 111001160 111002340 111004489
HAW: 110369634 110371928 110372428 110372664 110374859 110376990 110376991 110381163
PXY: 105381161 105382647 105382918 105384073 105384527 105389704
API: 103310702
DNX: 107164342
CLEC: 106664003
ZNE: 110840714
FCD: 110844332 110844333 110848257 110855694
DPX: DAPPUDRAFT_231053 DAPPUDRAFT_301515 DAPPUDRAFT_303686
ISC: IscW_ISCW014791
TUT: 107369493
BMY: Bm1_44405
HRO: HELRODRAFT_70715
LGI: LOTGIDRAFT_191692
CRG: 105317039 105323458 105325714 105325969 105340670
MYI: 110449544 110449545 110449546 110458931 110466215 110466238 110466244 110466251
OBI: 106869220 106869223
LAK: 106157857
SMM: Smp_033530.1 Smp_033540 Smp_140270
SHX: MS3_09619 MS3_09620 MS3_10972
OVI: T265_10122 T265_13980
EGL: EGR_04035 EGR_04036 EGR_04038 EGR_04039
NVE: NEMVE_v1g238099
EPA: 110245171 110252725
ADF: 107331745 107355635
HMG: 100200320
AQU: 100637791
CRB: 17876819
CSAT: 104761093
THJ: 104825040
GMX: 100787800 100811138 100814467
PVU: PHAVU_003G033300g PHAVU_003G060100g
VRA: 106765992
VAR: 108337975
CCAJ: 109805547 109815595
CAM: 101507622
ADU: 107458870
AIP: 107612497
LANG: 109362223
FVE: 105351700
PPER: 18776141 18794041
PMUM: 103323393 103344208
PAVI: 110763930 110769636
MDM: 103420529
PXB: 103931301
ZJU: 107406898
CMO: 103488873
CMAX: 111485563 111496416
CMOS: 111430094 111438126
CPEP: 111780719 111792674
RCU: 8286374
SLY: 101244166 101250605
SPEN: 107006389 107023668
SOT: 102587809
CANN: 107865865 107875989
NTA: 107769189 107793914 107820627
NSY: 104217663 104221924 104234288
NTO: 104099524
INI: 109163117 109165567 109189929
SIND: 105158283 105165498 105172075
OEU: 111372333
HAN: 110911119 110917661
LSV: 111896716
CCAV: 112510112 112511454
DCR: 108220469
NNU: 104598224
PDA: 103716007
EGU: 105051634
DCT: 110095551
AOF: 109830212
SMO: SELMODRAFT_112669 SELMODRAFT_78232
CRE: CHLREDRAFT_159999
CSL: COCSUDRAFT_55771
GSL: Gasu_14740 Gasu_24590
TTT: THITE_2124387
VAL: VDBG_02730
VDA: VDAG_03647
CFJ: CFIO01_05935
GLZ: GLAREA_06959
PTE: PTT_09714
BZE: COCCADRAFT_31994
BSC: COCSADRAFT_105489
BOR: COCMIDRAFT_39676 COCMIDRAFT_81758
ZTR: MYCGRDRAFT_36990
PFJ: MYCFIDRAFT_100760 MYCFIDRAFT_41956
BCOM: BAUCODRAFT_37592
SHS: STEHIDRAFT_98222
ADL: AURDEDRAFT_115777 AURDEDRAFT_115778 AURDEDRAFT_170147
GTR: GLOTRDRAFT_136682
MRR: Moror_6831
SCM: SCHCODRAFT_53501
UMA: UMAG_01815
PFP: PFL1_02949
SRE: PTSG_00844
ACAN: ACA1_172860 ACA1_172870 ACA1_362920
PTM: GSPATT00022346001
SMIN: v1.2.027692.t1(symbB.v1.2.027692.t1)
FCY: FRACYDRAFT_261152
AAF: AURANDRAFT_58590
SPAR: SPRG_20516
GTT: GUITHDRAFT_117185
HJA: BST95_12620
 » show all
Taxonomy
Reference
1  [PMID:31888]
  Authors
Ahmed NK, Felsted RL, Bachur NR.
  Title
Heterogeneity of anthracycline antibiotic carbonyl reductases in mammalian livers.
  Journal
Biochem Pharmacol 27:2713-9 (1978)
DOI:10.1016/0006-2952(78)90047-3
Reference
2  [PMID:666816]
  Authors
Lin YM, Jarabak J.
  Title
Isolation of two proteins with 9-ketoprostaglandin reductase and NADP-linked 15-hydroxyprostaglandin dehydrogenase activities and studies on their inhibition.
  Journal
Biochem Biophys Res Commun 81:1227-34 (1978)
DOI:10.1016/0006-291X(78)91267-6
Reference
3  [PMID:7005231]
  Authors
Wermuth B.
  Title
Purification and properties of an NADPH-dependent carbonyl reductase from human brain. Relationship to prostaglandin 9-ketoreductase and xenobiotic ketone reductase.
  Journal
J Biol Chem 256:1206-13 (1981)
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.184
IUBMB Enzyme Nomenclature: 1.1.1.184
ExPASy - ENZYME nomenclature database: 1.1.1.184
BRENDA, the Enzyme Database: 1.1.1.184
CAS: 89700-36-7

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Pathway (8)   
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Chemical substance (13)   
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Gene (6560)   
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